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Electrochemical Sensors Applied for In vitro Diagnosis

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Chemical Research in Chinese Universities Aims and scope

Abstract

Electrochemical sensing technology has received extensive attention from researchers for its unique detection and analysis methods as well as the promising applications in clinical diagnosis. Compared with other detection methods, such as capillary electrophoresis, high‐performance liquid chromatography and liquid chromatography-tandem mass spectrometry, the electrochemical sensor overcomes the disadvantages of expensive cost and complicated operation, as an ideal device for in vitro detection. In this article, we mainly introduce some methods for the detection of biologically important compounds and cancer biomarkers, and briefly summarize the characteristics of these methods at first. And then, we also focus on the latest research progress in the application of electrochemical sensing technology to biologically important compounds’ and cancer biomarkers’ detection. Finally, the development trend and challenges of electrochemical sensing technology for in vitro diagnosis are also prospected.

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References

  1. Wongkaew N., Simsek M., Griesche C., Baeumner A. J., Chemical Reviews, 2019, 119, 120

    Article  CAS  PubMed  Google Scholar 

  2. Cui F. Y., Zhou Z. R., Zhou H. S., Journal of the Electrochemical Society, 2020, 167, 037525

    Article  CAS  Google Scholar 

  3. Negahdary M., Biosensors & Bioelectronics, 2020, 152, 112018

    Article  CAS  Google Scholar 

  4. Cesewski E., Johnson B. N., Biosensors & Bioelectronics, 2020, 159, 112214

    Article  CAS  Google Scholar 

  5. Tang Z. W., Huang J., He H. L., Ma C. B., Wang K. M., Coordination Chemistry Reviews, 2020, 415, 213317

    Article  CAS  Google Scholar 

  6. Khosroshahi Z., Karimzadeh F., Kharaziha M., Allafchian A., Materials Science & Engineering C: Materials for Biological Applications, 2019, 108, 110216

    Article  CAS  Google Scholar 

  7. Rahsepara M., Foroughia F., Kim H., Sensors and Actuators B: Chemical, 2019, 282, 332

    Google Scholar 

  8. Zahed M. A., Barman S. C., Das P. S., Sharifuzzaman M., Yoon H. S., Yoon S. H., Park J. Y., Biosensors & Bioelectronics, 2020, 160, 112

    Article  CAS  Google Scholar 

  9. Raja M., Gupta P., Goyala R. N., Shimb Y. B., Sensors and Actuators B: Chemical, 2017, 239, 993

    Article  CAS  Google Scholar 

  10. Zheng Z. X., Feng Q. L., Zhu M. J., Shang J., Li M., Li C., Kou L. Z., Zheng J. B., Wang C. M., Analytica Chimica Acta, 2019, 1078, 231

    Article  CAS  PubMed  Google Scholar 

  11. Maheshwaran S., Akilarasan M., Chen S. M., Chen T. W., Tamilalagan E., Tzu C. Y., Lou B. S., Journal of the Electrochemical Society, 2020, 167, 066517

    Article  CAS  Google Scholar 

  12. Peng Y. F., Li R. Y., Sun X. L., Wang G. L., Li Z. J., Analytica Chimica Acta, 2020, 1121, 17

    Article  CAS  Google Scholar 

  13. Li R. Y., Pu T. L., Chu H. X., Shi J. S., Li Z. J., Sensors and Actuators B: Chemical, 2020, 309, 127709

    Article  CAS  Google Scholar 

  14. Zhang Q W., Jiang D. F., Xu C. S., Ge Y. C., Liu X. H., Wei Q. Q., Huang L. P., Ren X. Q., Wang C. D., Wang Y., Sensors and Actuators B: Chemical, 2020, 320, 128325

    Article  CAS  Google Scholar 

  15. Afzali M., Mostafavi A., Shamspur T., Talanta, 2019, 196, 92

    Article  CAS  PubMed  Google Scholar 

  16. Li Z., Zhang H. M., Zha Q. B., Zhai C. Y., Li W. B., Zeng L. X., Zhu M. S., Mikrochim Acta, 2020, 187, 526

    Article  CAS  PubMed  Google Scholar 

  17. Zhang Z., Yu W., Wang J., Luo D., Qiao X. Z., Qin X. Y., Wang T., Analytical Chemistry, 2017, 89, 1416

    Article  CAS  PubMed  Google Scholar 

  18. Amiri M., Arshi S., Electroanalysis, 2020, 32, 1391

    Article  CAS  Google Scholar 

  19. Krishnan R. G., Rejithamol R., Saraswathyamma B., Microchemical Journal, 2020, 155, 104745

    Article  CAS  Google Scholar 

  20. Cevik E., Cerit A., Gazel N., Yildiz H. B., Electroanalysis, 2018, 30, 2445

    Article  CAS  Google Scholar 

  21. Kaur G., Tomar M., Gupta V., Sensors and Actuators B: Chemical, 2018, 261, 460

    Article  CAS  Google Scholar 

  22. Hart N. T., Lane W. C., Garza L., Journal of Chemical Education, 2020, 97, 2254

    Article  CAS  Google Scholar 

  23. Tavakolian E., Tashkhourian J., Razmi Z., Kazemi H., Hosseini-Sarvari M., Sensors and Actuators B: Chemical, 2016, 230, 87

    Article  CAS  Google Scholar 

  24. Zhang X., Xie G. M., Gou D., Luo P., Yao Y., Chen H., Biosensors & Bioelectronics, 2019, 142, 111486

    Article  CAS  Google Scholar 

  25. Xu H. Y., Shao M. W., Chen T., Zhuo S. J., Wen C. Y., Peng M. F., Microporous and Mesoporous Materials, 2012, 153, 35

    Article  CAS  Google Scholar 

  26. Soares J. C., Soares A. C., Rodrigues V. C., Melendez M. E., Santos A. C., Faria E. F., Reis R. M., Carvalho A. L., Oliveira O. N., ACS Applied Materials & Interfaces, 2019, 11, 46645

    Article  CAS  Google Scholar 

  27. Lee G. Y., Park J. H., Chang Y. W., Cho S., Kang M. J., Pyun J. C., ACS Sensors, 2018, 3, 106

    Article  CAS  PubMed  Google Scholar 

  28. Anderson T. J., Defnet P. A., Zhang B., Analytical Chemistry, 2020, 92, 6748

    Article  CAS  PubMed  Google Scholar 

  29. Xue J. W., Yang L., Du Y., Ren Y., Ren X., Ma H. M., Wu D., Ju H. X., Li Y. Y., Wei Q., Sensors and Actuators B: Chemical, 2020, 321, 128454

    Article  CAS  Google Scholar 

  30. Clark L. C., Lyons C., Annals of the New York Academy of Sciences, 1962, 102, 29

    Article  CAS  PubMed  Google Scholar 

  31. Updike S. J., Hicks G. P., Science, 1967, 158, 270

    Article  CAS  PubMed  Google Scholar 

  32. Xu J., Xu K. K., Han Y., Wang D., Li X., Hu T., Yi H., Ni Z. H., Analyst, 2020, 14, 5141

    Article  Google Scholar 

  33. Huang Z. C., Zhang A. M., Zhang Q., Pan S. J., Cui D. X., Journal of the Electrochemical Society, 2019, 166, B1138

    Article  CAS  Google Scholar 

  34. Yoon H., Nah J., Kim H., Ko S., Sharifuzzaman M., Barman S. C., Xuan X., Kim J., Park J. Y., Sensors and Actuators B: Chemical, 2020, 311, 127866

    Article  CAS  Google Scholar 

  35. Zhang Y., Xu F. G., Sun Y. J., Shi Y., Wen Z. W., Li Z., Journal of Materials Chemistry, 2011, 21, 16949

    Article  CAS  Google Scholar 

  36. Ma L., Wang X. Y., Zhang Q. R., Tong X. L., Zhang Y., Li Z., Analytical Methods, 2018, 10, 3845

    Article  CAS  Google Scholar 

  37. Makrlikova A., Opekar F., Tuma P., Electrophoresis, 2015, 36, 1962

    Article  CAS  PubMed  Google Scholar 

  38. Solinova V., Zakova L., Jiracek J., Kasicka V., Analytica Chimica Acta, 2019, 1052, 170

    Article  CAS  PubMed  Google Scholar 

  39. Fukuda T., Muguruma H., Iwasa H., Tanaka T., Hiratsuka A., Shimizu T., Tsuji K., Kishimoto T., Analytical Biochemistry, 2020, 590, 113533

    Article  CAS  PubMed  Google Scholar 

  40. Azeredo N. F. B., Gonćalves J. M., Rossini P. O., Araki K., Wang J., Angnes L., Microchimica Acta, 2020, 187, 379.

    Article  CAS  PubMed  Google Scholar 

  41. Bao Y. Y., Li Z. P., Wang H. Y., Li N., Pan Q. L., Li J., Zhao J. G., Yang R. H., Feng F., Langmuir, 2020, 36, 7365

    Article  CAS  PubMed  Google Scholar 

  42. Ma L., Zhang Q. R., Wu C., Zhang Y., Zeng L. T., Analytica Cheimica Acta., 2019, 1055, 17

    Article  CAS  Google Scholar 

  43. Shrestha B. K., Ahmad R., Shrestha S., Park C. H., Kim C. S., Biosensors & Bioelectronics, 2017, 94, 686

    Article  CAS  Google Scholar 

  44. Willyam S. J., Saepudin E., Ivandini T. A., Analytical Methods, 2020, 12, 3454

    Article  CAS  PubMed  Google Scholar 

  45. Akshaya K. B., Varghese A., Nidhin M., George L., Journal of the Electrochemical Society, 2019, 166, B1016

    Article  CAS  Google Scholar 

  46. Thakur N., Kumar M., Das Adhikary S., Mandal D., Nagaiah T. C., Chemical Communications, 2019, 55, 5021

    Article  CAS  PubMed  Google Scholar 

  47. Gao J., Huang W. Z., Chen Z. P., Yi C. Q., Jiang L. L., Sensors and Actuators B: Chemical, 2019, 287, 102

    Article  CAS  Google Scholar 

  48. Shervedani R. K., Amini A., Bioelectrochemistry, 2012, 84, 25

    Article  CAS  PubMed  Google Scholar 

  49. Xu H. Y., Shao M. W., Chen T., Zhuo S. J., Wen C. Y., Peng M. F., Microporous and Mesoporous Materials, 2012, 153, 35

    Article  CAS  Google Scholar 

  50. Atta N. F., Galal A., Ali S. M., Hassan S. H., Ionics, 2015, 21, 2371

    Article  CAS  Google Scholar 

  51. Huang R. F., Guo L. H., Science China Chemistry, 2010, 53, 1778

    Article  CAS  Google Scholar 

  52. Si Y., Zhang A. Y., Liu C., Pei D. N., Yu H. Q., Analytical Chemistry, 2020, 92, 9629

    Article  CAS  PubMed  Google Scholar 

  53. Thakur N., Chaturvedi A., Mandal D., Nagaiah T. C., Chemical Communications, 2020, 56, 8448

    Article  CAS  PubMed  Google Scholar 

  54. Anuar N. S., Basirun W. J., Shalauddin M., Akhter S., RSC Advances, 2020, 10, 17336

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Senel M., Dervisevic M., Alhassen S., Alachkar A., Voelcker N. H., Analytical Chemistry, 2020, 92, 7746

    Article  CAS  PubMed  Google Scholar 

  56. Sun X. J., Zhang L., Zhang X. H., Liu X. X., Jian J., Kong D. C., Zeng D. C., Yuan H. M., Feng S. H., Biosensors & Bioelectronics, 2020, 153, 112045

    Article  CAS  Google Scholar 

  57. Zhao S., Zhang Y. C., Ding S. T., Fan J. C., Luo, Z., Liu K. G., Shi Q., Li W. C., Zang G. C., Journal of Electroanalytical Chemistry, 2019, 834, 33

    Article  CAS  Google Scholar 

  58. Lee M. H., Thomas J. L., Chang Y. C., Tsai Y. S., Liu B. D., Lin H. Y., Biosensors & Bioelectronics, 2016, 79, 789

    Article  CAS  Google Scholar 

  59. Martin A., Batalla P., Hernandez-Ferrer J., Martinez M. T., Escarpa A., Biosensors & Bioelectronics, 2015, 68, 163

    Article  CAS  Google Scholar 

  60. Martínez-Perinán E., Revenga-Parra M., Zamora F., Pariente F., Lorenzo E., Sensors and Actuators B: Chemical, 2016, 236, 773

    Article  CAS  Google Scholar 

  61. Dhara K., Debiprosad R. M., Analytical Biochemistry, 2019, 586, 113415

    Article  CAS  PubMed  Google Scholar 

  62. Hashemi S. A., Mousavi S. M., Bahrani S., Ramakrishna S., Babapoor A., Chiang W. H., Analytica Chimica Acta, 2020, 1107, 183

    Article  CAS  PubMed  Google Scholar 

  63. Zhao L. F., Li S. J., He J., Tian G. H., Wei Q., Li H., Biosensors & Bioelectronics, 2013, 49, 222

    Article  CAS  Google Scholar 

  64. Wei Y. C., Li Y., Li N., Zhang Y., Yan T., Ma H. M., Wei Q., Biosensors & Bioelectronics, 2016, 79, 482

    Article  CAS  Google Scholar 

  65. Cui M., Wang Y., Jiao M. X., Jayachandran S., Wu Y. M., Fan X. J., Luo X. L., ACS Sensors, 2017, 2, 490

    Article  CAS  PubMed  Google Scholar 

  66. Li G. Y., Li S. S., Wang Z. H., Xue Y. W., Dong C. Y., Zeng J. X., Huang Y., Liang J. J., Zhou Z. D., Analytical Biochemistry, 2018, 547, 37

    Article  CAS  PubMed  Google Scholar 

  67. Huang X. Y., Cui B. B., Ma Y. S., Yan X., Xia L., Zhou N., Wang M. H., He L. H., Zhang Z. H., Analytica Chimica Acta, 2019, 1078, 125

    Article  CAS  PubMed  Google Scholar 

  68. Azimzadeh M., Rahaie M., Nasirizadeh N., Ashtari K., Naderi-Manesh H., Biosensors & Bioelectronics, 2016, 77, 99

    Article  CAS  Google Scholar 

  69. Yang D. W., Cheng W. B., Chen X. F., Tang Y. G., Miao P., Analyst, 2018, 143, 5352

    Article  CAS  PubMed  Google Scholar 

  70. Kutluk H., Bruch R., Urban G. A., Dincer C., Biosensors & Bioelectronics, 2020, 148, 111824

    Article  CAS  Google Scholar 

  71. Xu S., Chang Y. Y., Wu Z. Y., Li Y. R., Yuan R., Chai Y. Q., Biosensors & Bioelectronics, 2020, 149, 111848

    Article  CAS  Google Scholar 

  72. Moccia M., Caratelli V., Cinti S., Pede B., Avitabile C., Saviano M., Imbrani A. L., Moscone D., Arduini F., Biosensors & Bioelectronics, 2020, 165, 112371

    Article  CAS  Google Scholar 

  73. Liu G. D., Wang J., Wu H., Wai C. M., Lin Y. H., Analytical Chemistry, 2007, 79, 7644

    Article  CAS  PubMed  Google Scholar 

  74. Kavosi B., Salimi A., Hallaj R., Moradi F., Biosensors & Bioelectronics, 2015, 74, 915

    Article  CAS  Google Scholar 

  75. Ding C. F., Wang X. Y., Luo X. L., Analytical Chemistry, 2019, 91, 15846

    Article  CAS  PubMed  Google Scholar 

  76. Liang H., Xu H. B., Zhao Y. T., Zheng J., Zhao H., Li G. L., Li C. P., Biosensors & Bioelectronics, 2019, 144, 111691

    Article  CAS  Google Scholar 

  77. Zhao Y., Liu H., Shi L., Zheng W. W., Jing X. H., Sensors and Actuators B: Chemical, 2020, 315, 128155

    Article  CAS  Google Scholar 

  78. Liu X. B., Yue T., Qi K., Qiu Y. B., Guo X. P., Talanta, 2020, 217, 121042

    Article  CAS  PubMed  Google Scholar 

  79. Gold P., Freedman S. O., Journal of Experimental Medicine, 1965, 121, 439

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. Wu J., Tang J. H., Dai Z., Yan F., Ju H. X., El Murr N., Biosensors & Bioelectronics, 2006, 22, 102

    Article  CAS  Google Scholar 

  81. Tang D. P., Yuan R., Chal Y. Q., Analytical Chemistry, 2008, 80, 1582

    Article  CAS  PubMed  Google Scholar 

  82. Zhang X. Y., Yu Y., Shen J. L., Qi W., Wang H., Talanta, 2020, 212, 120794

    Article  CAS  PubMed  Google Scholar 

  83. Zheng J., Wang J. P., Song D. D., Xu J. L., Zhang M., ACS Applied Nano Materials, 2020, 3, 3449

    Article  CAS  Google Scholar 

  84. Lan Q. C., Ren C. L., Lambert A., Zhang G. C., Li J., Cheng Q., Hu X. Y., Yang Z. J., ACS Sustainable Chemistry & Engineering, 2020, 8, 4392

    Article  CAS  Google Scholar 

  85. Pakchin P. S., Ghanbari H., Saber R., Omidi Y., Biosensors & Bioelectronics, 2018, 122, 68

    Article  CAS  Google Scholar 

  86. Fan Y., Shi S. Y., Ma J. S., Guo Y. H., Biosensors & Bioelectronics, 2019, 135, 1

    Article  CAS  Google Scholar 

  87. Pakchin P. S., Fathi M., Ghanbari H., Saber R., Omidi Y., Biosensors & Bioelectronics, 2020, 153, 112029

    Article  CAS  Google Scholar 

  88. de Castro A. C. H., Alves L. M., Siquieroli A. C. S., Madurro J. M., Brito-Madurro A. G., Microchemical Journal., 2020, 155, 104746

    Article  CAS  Google Scholar 

  89. Lu C. Y., Han J. T., Sun X. Y., Yang G., Sensors, 2020, 20, 6073

    Article  CAS  PubMed Central  Google Scholar 

  90. Cao J., Zhao X. P., Younis M. R., Li Z. Q., Xia X. H., Wang C., Analytical Chemistry, 2017, 89, 10957

    Article  CAS  PubMed  Google Scholar 

  91. Peng Y., Pan Y. H., Han Y. W., Sun Z. W., Jalalah M., Al-Assiri M. S., Harraz F. A., Yang J., Li G. X., Analytical Chemistry, 2020, 92, 13478

    Article  CAS  PubMed  Google Scholar 

  92. Liu P. F., Wang L., Zhao K. R., Liu Z. J., Cao H. X., Ye S. Y., Liang G. X., Sensors and Actuators B: Chemical, 2020, 316, 128131

    Article  CAS  Google Scholar 

  93. Tang S. T., Shen H. W., Hao Y. X., Huang Z. L., Tao Y. Y., Peng Y., Guo Y. C., Xie G. M., Feng W. L., Biosensors & Bioelectronics, 2020, 104, 72

    Article  CAS  Google Scholar 

  94. Zhang W. Z., Chen H., Yang M. H., Liao L. Q., Materials Letters, 2020, 276, 128219

    Article  CAS  Google Scholar 

  95. Du X., Zhang Z. H., Zheng X. D., Zhang H. Y., Dong D., Zhang Z. G., Liu M., Zhou J., Nature Communications, 2020, 11, 192

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  96. Granato T., Porpora M. G., Longo F., Angeloni A., Manganaro L., Anastasi E., Clinica Chimica Acta, 2015, 446, 147

    Article  CAS  Google Scholar 

  97. Zamorano A. S., Hagemann A. R., Morrison L., Lee J. A., Liao L. M., Brinton L. A., Park Y., Toriola A. T., Gynecologic Oncology, 2019, 155, 105

    Article  PubMed  Google Scholar 

  98. Mattarozzi M., Giannetto M., Careri M., Talanta, 2020, 217, 120991

    Article  CAS  PubMed  Google Scholar 

  99. Doxtater K., Tripathi M. K., Khan M. M., Neural Regeneration Research, 2020, 15, 2253

    Article  PubMed  PubMed Central  Google Scholar 

  100. Zhang Y. T, Figueroa-Miranda G., Wu C. T., Willbold D., Offenhausser A., Mayer D., Nanoscale, 2020, 12, 16501

    Article  CAS  PubMed  Google Scholar 

  101. Tang P. P., Wang Y. B., He F. Y., Journal of Saudi Chemical Society, 2020, 24, 620

    Article  CAS  Google Scholar 

  102. Feng D. Z., Su J., He G. F., Xu Y., Wang C. G., Zheng M. M., Qian Q. L., Mi X. Q., Biosensors Basel, 2020, 10, 78

    Article  CAS  PubMed Central  Google Scholar 

  103. Huang R. R., He L., Xia Y. Y., Xu H. P., Liu C., Xie H., Wang S., Peng L. J., Liu Y. F., Liu Y., He N. Y., Li Z. Y., Small, 2019, 15, 1900735

    Article  CAS  Google Scholar 

  104. Gorgannezhad L., Umer M., Islam M. N., Nguyen N. T., Shiddiky M. J. A., Lab on a Chip, 2018, 18, 1174

    Article  CAS  PubMed  Google Scholar 

  105. Rahman M., Cui D. X., Zhou S. K., Zhang A., Chen D., Analytical Methods, 2020, 12, 440

    Article  CAS  Google Scholar 

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Acknowledgements

This work is partially supported by the National Natural Science Foundation of China(Nos.21605113, 21925405, 21635002 and 201874005), the National Key Research and Development Program of China(No.2018YFA0208800), and the Project of the Chinese Academy of Sciences(Nos.XDA23030106 and YJKYYQ20180044).

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  1. These authors contributed equally to this work.

Authors and Affiliations

  1. Life and Health Research Institute, School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin, 300384, P. R. China

    Duo Li, Chao Wu, Xuehui Tang, Yue Zhang & Tie Wang

  2. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China

    Tie Wang

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  1. Duo Li
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  2. Chao Wu
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Correspondence to Yue Zhang or Tie Wang.

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Li, D., Wu, C., Tang, X. et al. Electrochemical Sensors Applied for In vitro Diagnosis. Chem. Res. Chin. Univ. 37, 803–822 (2021). https://doi.org/10.1007/s40242-021-0387-0

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