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In vitro degradation and biocompatibility of Ca-P coated magnesium alloy

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Abstract

Calcium-phosphate compounds(Ca-P) coating was prepared on an Mg-Al alloy(AZ60). Biodegradation of Ca-P coated magnesium alloy was evaluated in simulated body fluid(SBF) by examining the changes in magnesium ion concentration and pH value, which indicated that the Ca-P coating on magnesium alloy strongly affected the corrosion of magnesium alloy. Osteoblast MC3T3-E1 cells were utilized to investigate the cellular cytocompatibility. The cytocompatibility was measured by carrying out a series of tests, such as cholecystokinin-octapeptide(CCK-8) test, alkaline phosphatase activity(ALP) test, cellular morphology of hematoxylin-eosin(HE) staining and the induction of apoptosis. It was found that the cell function showed better in the Ca-P coated Mg-alloy extract than in the uncoated magnesium alloy extract. In summary, the results indicate that the Ca-P coating can improve the corrosion resistance of magnesium alloy and elevate cellular proliferation and differentiation of osteoblast MC3T3-E1 cells.

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Authors and Affiliations

  1. The First Hospital of Jilin University, Changchun, 130021, P. R. China

    Xing Xiao & Qing-san Zhu

  2. College of Materials Science and Engineering, Jilin University, Changchun, 130022, P. R. China

    Ying-chao Su & Guang-yu Li

Authors
  1. Xing Xiao
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  2. Qing-san Zhu
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  3. Ying-chao Su
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  4. Guang-yu Li
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Corresponding author

Correspondence to Guang-yu Li.

Additional information

Supported by the National Natural Science Foundation of China(No.31070841).

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Xiao, X., Zhu, Qs., Su, Yc. et al. In vitro degradation and biocompatibility of Ca-P coated magnesium alloy. Chem. Res. Chin. Univ. 29, 285–289 (2013). https://doi.org/10.1007/s40242-013-2314-5

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  • DOI: https://doi.org/10.1007/s40242-013-2314-5

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