Skip to main content

Advertisement

Log in

The relationship between personality disorder, depression and eating disorder with treatment adherence in patients with type 2 diabetes; a cross-sectional study in diabetic patients in Iran

  • Research article
  • Published:
Journal of Diabetes & Metabolic Disorders Aims and scope Submit manuscript

Abstract

Purpose

Adherence to treatment is of great importance in patients with diabetes mellitus due to its necessity and benefits. The purpose of this study was to evaluate the relationship between personality disorder, depression and eating disorder with appropriate treatment acceptance and follow-up in patients with type 2 diabetes.

Methods

This cross-sectional study was performed in Imam Ali Medical Education Center in Karaj city of Alborz province of Iran. A total of 1320 patients were evaluated and were screened according to the inclusion criteria, including type 2 diabetes and those over 18 years of age. Finally, considering the exclusion criteria, 600 patients with type 2 diabetes were included in the study. Patients were divided into 4 groups. 150 patients with type 2 diabetes in the control group, 150 patients with type 2 diabetes with major depressive disorder, 150 patients with type 2 diabetes with personality disorder and 150 patients with type 2 diabetes and eating disorder were studied. Questionnaires used in the study included Hamilton Depression Rating Scale(HAM-D) for depression, Minnesota Multiphasic Personality Inventory II (MMPI II) questionnaire for personality disorders and Eating Disorder Diagnostic Scale(EDDS) for eating disorder. The Murisky questionnaire also assessed adherence to treatment in patients, which included 8 questions. Scores measure the degree of adherence to treatment.

Results

600 patients with type 2 diabetes were studied. Patients were divided into 4 groups (each group consisting of 150 patients) of control, depression, personality disorder and eating disorder. Mean age, sex, marital status and duration of diabetes were not significantly different in the study groups (P > 0.05). The mean Murisky score in patients with depression and personality disorder was significantly lower than the control group (P < 0.05) but the mean Murisky score in patients with eating disorder was not significantly different (P > 0.05). Patients with depression, paranoid, schizotypal, antisocial, borderline, avoidant and dependent personality disorder had less adherent to treatment than the control group.

Conclusions

Early psychiatric evaluation of patients with diabetes and identification of possible disorders can help improve diabetes control.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Navipour E, et al. Predict of risk factors associated with diabetes type 2 by using logistic regression. 2017;12(2):59–65.

  2. Kayedi M, et al. The associaty of chlamydia pneumoniae, helicobacter pylori herpes simplex virus type 1 and Cytomegalovirus in the northern Persian gulf population. ISMJ. 2015;18(1):135–46.

    Google Scholar 

  3. Klein R, Klein BEK, Moss SE, Davis MD, DeMets DL. The Wisconsin epidemiologic study of diabetic retinopathy: IV. Diabetic macular edema. Ophthalmology. 1984;91(12):1464–74.

    Article  CAS  Google Scholar 

  4. Tuomilehto J, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001;344(18):1343–50.

    Article  CAS  Google Scholar 

  5. Amini M, Parvaresh E. Prevalence of macro-and microvascular complications among patients with type 2 diabetes in Iran: a systematic review. Diabetes Res Clin Pract. 2009;83(1):18–25.

    Article  Google Scholar 

  6. Azizi Soleiman F, et al. The relationship between inflammation, oxidative stress, and metabolic risk factors in type 2 diabetic patients. Iranian J Diabetes Obesity. 2013;5(4):151–6.

    Google Scholar 

  7. Klein HA, Lippa KD. Assuming control after system failure: type II diabetes self-management. Cogn Tech Work. 2012;14(3):243–51.

    Article  Google Scholar 

  8. Balducci S, Sacchetti M, Haxhi J, Orlando G, D'Errico V, Fallucca S, et al. Physical exercise as therapy for type 2 diabetes mellitus. Diabetes Metab Res Rev. 2014;30(S1):13–23.

    Article  Google Scholar 

  9. Kaholokula, J.K.A., et al., Biological, psychosocial, and sociodemographic variables associated with depressive symptoms in persons with type 2 diabetes. J Behavior Med, 2003. 26(5): p. 435–458.

  10. Eskandari Khanghahi M, et al. Frequency of psychiatric and psychological disorders in patients with type II diabetes. J Mazandaran Univ Med Sci. 2017;27(155):37–45.

    Google Scholar 

  11. Jokela M, Elovainio M, Nyberg ST, Tabák AG, Hintsa T, Batty GD, et al. Personality and risk of diabetes in adults: pooled analysis of 5 cohort studies. Health Psychol. 2014;33(12):1618–21.

    Article  Google Scholar 

  12. Wisting L, et al. Adolescents with type 1 diabetes–the impact of gender, age, and health-related functioning on eating disorder psychopathology. PLoS One. 2015;10(11):e0141386.

  13. Papadopoulos AA, Kontodimopoulos N, Frydas A, Ikonomakis E, Niakas D. Predictors of health-related quality of life in type II diabetic patients in Greece. BMC Public Health. 2007;7(1):186.

    Article  Google Scholar 

  14. Dunbar-Jacob J, Mortimer-Stephens M. Treatment adherence in chronic disease. J Clin Epidemiol. 2001;54(12):S57–60.

    Article  Google Scholar 

  15. Chisholm-Burns MA, Spivey CA. The'cost'of medication nonadherence: consequences we cannot afford to accept. J Am Pharmacists Assoc. 2012;52(6):823–6.

    Article  Google Scholar 

  16. Jack K, McLean SM, Moffett JK, Gardiner E. Barriers to treatment adherence in physiotherapy outpatient clinics: a systematic review. Man Ther. 2010;15(3):220–8.

    Article  Google Scholar 

  17. Williams JB. A structured interview guide for the Hamilton depression rating scale. Arch Gen Psychiatry. 1988;45(8):742–7.

    Article  CAS  Google Scholar 

  18. Zimmerman M, Martinez JH, Young D, Chelminski I, Dalrymple K. Severity classification on the Hamilton depression rating scale. J Affect Disord. 2013;150(2):384–8.

    Article  Google Scholar 

  19. Ebrahimi A, et al. Reliability, validity, factor and discrimination power analysis of young mania rating scale among unipolar, bipolar depression and healthy people. 2017;16(3):333–344.

  20. Butcher JN. Minnesota multiphasic personality inventory. The Corsini Encyclopedia of Psychology. 2010;1–3. https://doi.org/10.1002/9780470479216.corpsy0573.

  21. Dehghani M, et al. Standardization and psychometric properties of Minnesota Multiphasic Personality Inventory (MMPI-2). J Psych. 2010;14(3):299–318.

  22. Stice E, Telch CF, Rizvi SL. Development and validation of the eating disorder diagnostic scale: a brief self-report measure of anorexia, bulimia, and binge-eating disorder. Psychol Assess. 2000;12(2):123–31.

    Article  CAS  Google Scholar 

  23. Khabir L, Mohamadi N, Rahimi C. The validation of eating disorder diagnostic scale (EDDS). J Kermanshah Univ Med Sci. 2014;18(2):100–7.

    Google Scholar 

  24. Morisky DE. Predictive validity of a medication adherence measure for hypertension control. J Clin Hypertens. 2008;10:348–54.

    Article  Google Scholar 

  25. Tan X, Patel I, Chang J. Review of the four item Morisky medication adherence scale (MMAS-4) and eight item Morisky medication adherence scale (MMAS-8). Innovations Pharm. 2014;5(3):5.

    Article  Google Scholar 

  26. Ben AJ, Neumann CR, Mengue SS. The brief medication questionnaire and Morisky-green test to evaluate medication adherence. Revista de saude publica. 2012;46(2):279–89.

    Article  Google Scholar 

  27. Al-Qazaz HK, et al. The eight-item Morisky medication adherence scale MMAS: translation and validation of the Malaysian version. Diabetes Res Clin Pract. 2010;90(2):216–21.

    Article  Google Scholar 

  28. Moharamzad Y, Saadat H, Nakhjavan Shahraki B, Rai A, Saadat Z, Aerab-Sheibani H, et al. Validation of the Persian version of the 8-item Morisky medication adherence scale (MMAS-8) in Iranian hypertensive patients. Global J Health Sci. 2015;7(4):173–83.

    Article  Google Scholar 

  29. Zhang J, et al. Comparative study of the influence of diabetes distress and depression on treatment adherence in Chinese patients with type 2 diabetes: a cross-sectional survey in the People’s republic of China. Neuropsychiatr Dis Treat. 2013;9:1289.

    PubMed  Google Scholar 

  30. Zhang Y, Ting RZW, Yang W, Jia W, Li W, Ji L, et al. Depression in Chinese patients with type 2 diabetes: associations with hyperglycemia, hypoglycemia, and poor treatment adherence: 中国人 2 型糖尿病抑郁情况及其与高血糖, 低血糖及治疗依从性关系的研究. J Diabetes. 2015;7(6):800–8.

    Article  CAS  Google Scholar 

  31. Gonzalez JS, Peyrot M, McCarl LA, Collins EM, Serpa L, Mimiaga MJ, et al. Depression and diabetes treatment nonadherence: a meta-analysis. Diabetes Care. 2008;31(12):2398–403.

    Article  Google Scholar 

  32. Niraula K, Kohrt BA, Flora MS, Thapa N, Mumu SJ, Pathak R, et al. Prevalence of depression and associated risk factors among persons with type-2 diabetes mellitus without a prior psychiatric history: a cross-sectional study in clinical settings in urban Nepal. BMC Psychiatry. 2013;13(1):309.

    Article  Google Scholar 

  33. Egede LE, Dismuke CE. Serious psychological distress and diabetes: a review of the literature. Current Psychiatry Reports. 2012;14(1):15–22.

    Article  Google Scholar 

  34. Kilbourne AM, Reynolds CF III, Good CB, Sereika SM, Justice AC, Fine MJ. How does depression influence diabetes medication adherence in older patients? Am J Geriatr Psychiatry. 2005;13(3):202–10.

    Article  Google Scholar 

  35. Maeda U, Shen BJ, Schwarz ER, Farrell KA, Mallon S. Self-efficacy mediates the associations of social support and depression with treatment adherence in heart failure patients. Int J Behavior Med. 2013;20(1):88–96.

    Article  Google Scholar 

  36. Widiger TA and Costa Jr PT. Personality disorders and the five-factor model of personality. (3rd ed.). 2013: American Psychological Association. https://doi.org/10.1037/13939-000.

  37. Pollock-BarZiv SM, Davis C. Personality factors and disordered eating in young women with type 1 diabetes mellitus. Psychosomatics. 2005;46(1):11–8.

    Article  Google Scholar 

  38. Kruisdijk F, Hopman-Rock M, Beekman ATF, Hendriksen IJM. Personality traits as predictors of exercise treatment adherence in major depressive disorder: lessons from a randomised clinical trial. Int J Psychiatry Clin Pract. 2020;24(4):380–6.

    Article  Google Scholar 

  39. Nieto-Martínez R, González-Rivas JP, Medina-Inojosa JR, Florez H. Are eating disorders risk factors for type 2 diabetes? A systematic review and meta-analysis. Current Diabetes Reports. 2017;17(12):138.

    Article  Google Scholar 

  40. Ciechanowski PS, Katon WJ, Russo JE. Depression and diabetes: impact of depressive symptoms on adherence, function, and costs. Arch Intern Med. 2000;160(21):3278–85.

    Article  CAS  Google Scholar 

  41. Egede LE, Ellis C. Diabetes and depression: global perspectives. Diabetes Res Clin Pract. 2010;87(3):302–12.

    Article  Google Scholar 

Download references

Acknowledgements

We thank all the patients who collaborated to carry out this study. We also thank the officials of Imam Ali Medical Education Center.

Funding

This study was conducted with the financial support of Alborz University of Medical Sciences. (IR.ABZUMS.REC. 1398.143).

Author information

Authors and Affiliations

Authors

Contributions

All authors had the same role in the various stages of preparing this article.

Corresponding author

Correspondence to Atefeh Zandifar.

Ethics declarations

Conflicts of interest/competing interests

There is no conflict of interest.

Availability of data and material

All study data and materials are available.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jalali, N., Taghavi Kojidi, H., Badrfam, R. et al. The relationship between personality disorder, depression and eating disorder with treatment adherence in patients with type 2 diabetes; a cross-sectional study in diabetic patients in Iran. J Diabetes Metab Disord 20, 153–159 (2021). https://doi.org/10.1007/s40200-020-00722-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40200-020-00722-x

Keywords

Navigation