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Role of mitochondria in pathogenesis of type 2 diabetes mellitus

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Abstract

Type 2 diabetes mellitus (T2DM) is global health problem. An estimated 425 million people in the world had diabetes in 2017. It is a major cause of morbidity and mortality worldwide. Although, pathogenesis of T2DM and its complications have been focus of medical research for long, much remains to be learned. A better understanding of molecular pathogenesis is essential for more effective preventive and therapeutic interventions. Role of mitochondria in pathogenesis of metabolic problems such as obesity, metabolic syndrome, and T2DM is the focus of many recent research studies. Mitochondrial dysfunction contributes to the oxidative stress and systemic inflammation leading to insulin resistance (IR). Mitochondria are also essential for pancreatic beta cell insulin secretion. Hence, mitochondria are important players in the pathogenesis of T2DM. In this article, pathogenesis of T2DM is examined from a mitochondrial perspective.

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Dr. Pankaj Prasun does not have any funding sources to declare related to the study and to the article preparation.

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  1. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place - Box 1497, New York, NY, 10029, USA

    Pankaj Prasun

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Dr. Pankaj Prasun drafted the initial and all subsequent versions of the manuscript and has approved the article as it is written.

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Dr. Pankaj Prasun has no potential conflicting or competing interests that could in any way affect the conduct of the study, interpretation of results, or preparation of the manuscript.

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Prasun, P. Role of mitochondria in pathogenesis of type 2 diabetes mellitus. J Diabetes Metab Disord 19, 2017–2022 (2020). https://doi.org/10.1007/s40200-020-00679-x

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