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Association between chronic hepatitis B infection and metabolic syndrome

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Abstract

Purpose

The association between chronic hepatitis B (CHB) infection and metabolic syndrome (MetS) remains inconclusive. This study was designed to determine the association between CHB infection and MetS among the US population with updated data and adjustments for a comprehensive set of risk factors.

Methods

Adults aged 18 years or older who were clinically assessed for Hepatitis B and MetS from the National Health and Nutrition Examination Survey (NHANES) 2003–2004, 2005–2006, 2007–2008, 2009–2010, 2011–2012, and 2013–2014 cycles were included in the study (N = 53,392,666). MetS was defined according to the NCEP/ATP III guideline. CHB was identified by the seropositivity of Hepatitis B surface antigen and core antibody in the absence of Hepatitis B surface antibody. Rao-Scott χ2test and logistic regressions were employed in the analyses.

Results

MetS was less prevalent among adults with CHB compared to adults without CHB (12.1% vs. 18.8%, p = 0.073). In adjusted analyses, adults with CHB were 48% less likely to have MetS compared to those without CHB (95% Confidence Interval [CI]: 0.29–0.94). Regarding individual component of MetS, CHB was inversely associated with high waist circumference (AOR = 0.32, 95% CI: 0.21–0.49) and hypoalphalipoproteinemia (AOR = 0.48, 95% CI: 0.25–0.91). No association between CHB and other metabolic components were found.

Conclusions

CHB was inversely associated with MetS, high waist circumference, and hypoalphalipoproteinemia. No significant association was found between CHB and other MetS components.

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Acknowledgements

Each author acknowledges she has participated in the work in a substantive way and is prepared to take full responsibility for the work. The authors did not receive assistance from other entities for writing this manuscript.

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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Pharmaceutical Systems and Policy, School of Pharmacy, West Virginia University, 1 Medical Center Drive, PO Box 9510, Morgantown, WV, 26506, USA

    Xiaohui Zhao, Drishti Shah & Usha Sambamoorthi

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  1. Xiaohui Zhao
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  3. Usha Sambamoorthi
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Correspondence to Xiaohui Zhao.

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Conflict of interest

The project was partially supported by the National Institute of General Medical Sciences, U54GM104942. Xiaohui Zhao, Drishti Shah, and Usha Sambamoorthi have received research grants from Regeneron Pharmaceuticals, Inc. and Teva Pharmaceutical Industries Ltd. However, the authors have no significant relationships with or financial interests in any commercial companies related to this study or article.

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Zhao, X., Shah, D. & Sambamoorthi, U. Association between chronic hepatitis B infection and metabolic syndrome. J Diabetes Metab Disord 17, 223–232 (2018). https://doi.org/10.1007/s40200-018-0364-4

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