Abstract
Background
Diabetic nephropathy (DN) is the major cause of end-stage renal disease. Recent studies suggest that it is probable that uric acid is involved in the pathogenesis of diabetic nephropathy. This study aim was to investigate the association between serum uric acid and kidney function in Iranian patients with type 2 diabetes mellitus.
Methods
In this case-control study, a total of 201 diabetic patients with or without impaired kidney function (glomerular filtration rate/GFR < 60 and GFR ≥ 60) were selected. In both groups, serum fasting glucose (FBS), HbA1c, urea, creatinine, uric acid and lipid profile, urine albumin and GFR were measured and results were compared between the two groups. The results also categorized into three groups based on uric acid tertiles.
Results
Serum levels of uric acid, urea and creatinine as well as urine albumin/creatinine ratio (ACR) were significantly different between the two groups. GFR, creatinine and also urea were significantly different between uric acid tertiles (p < 0.05).
Conclusions
Serum uric acid is associated with decreased GFR as well as albuminuria and can be used as an indicator of DN.
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Abbreviations
- ACR:
-
Albumin to Creatinine Ratio
- ANOVA:
-
One-way analysis of variance
- CKD:
-
Chronic Kidney Diseases
- DN:
-
Diabetic Nephropathy
- ESRD:
-
End Stage Renal Diseases
- FBS:
-
Fasting Blood Sugar
- GFR:
-
Glomerular Filtration Rate
- MDRD:
-
Modification of Diet in Renal Disease
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Acknowledgements
The authors wish to thank staffs at Diabetes Research Center for their assistance in the study.
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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
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Contributions
FR: study design and concept, performing assay and approving final manuscript.
FB: Data collection, statistical analysis and approving final manuscript.
EN: data interpretation, writing first manuscript draft and approving final manuscript.
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The study protocol was approved by the Ethics Committee of the Endocrinology and Metabolism Research Institute (EMRI) affiliated to Tehran University of Medical Sciences and all participants signed written informed consent.
Competing interest
The authors have no conflict of interest regarding this study to report.
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Razi, F., Nasli-Esfahani, E. & Bandarian, F. Association of serum uric acid with nephropathy in Iranian type 2 diabetic patients. J Diabetes Metab Disord 17, 71–75 (2018). https://doi.org/10.1007/s40200-018-0340-z
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DOI: https://doi.org/10.1007/s40200-018-0340-z