Abstract
In this study, we fabricated poly(3-hydroxybutyrate-3-hydroxyvalerate) (PHBV) coatings doped with Gd3+ (1, 5, and 10 × 10−4 mol/L) on Ti6Al4V alloy for the first time to promote soft tissue sealing around dental implants. The corrosion resistance of Gd3+-modified PHBV-coated Ti6Al4V was studied by electrochemical and immersion tests, respectively, whereas CCK-8 and RT-PCR evaluated the biocompatibility to human gingival fibroblasts (HGFs) and human umbilical vein endothelial cells (HUVECs). It was found that the Gd3+-modified PHBV coating could enhance the corrosion resistance of Ti6Al4V. In vitro cell tests showed that PHBV coatings with and without Gd3+ addition could promote adhesion and proliferation of HGFs and HUVECs, showing a Gd3+ content-dependent manner. Moreover, it was found that the PDA-PHBV@1Gd showed the best proliferation to HGFs by up-regulating gene expressions of VINCULIN, ITGB1, and ITGA3, whereas the best response to HUVECs with the highest gene expression of eNOS and HIF-1α genes was found in the PDA-PHBV@5Gd-coated group.
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Acknowledgements
This work was financially supported by the National Natural Science Foundation of China (No. 51801198), the Funds of Scientific and Technological Plan of Fujian Province (No. 2020Y0083), the National Key Technologies Research and Development Program of China (2016YFC1100502), and the Joint Funds of Scientific and Technological Innovation Program of Fujian Province (No. 2017Y9059), the Natural Science Foundation of Fujian Province (No. 2019I0027), and the Funds of Scientific and Technological Plan of Fujian Province (No. 2020L3026).
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Qin, S., Xu, X., Lu, Y. et al. Doping Gd3+ Ion in PDA-PHBV Coating on Ti6Al4V Alloy for Enhancing Corrosion Resistance and Proliferation of Human Gingival Fibroblasts and Human Umbilical Vein Endothelial Cells. Acta Metall. Sin. (Engl. Lett.) 35, 812–824 (2022). https://doi.org/10.1007/s40195-021-01292-4
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DOI: https://doi.org/10.1007/s40195-021-01292-4