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Comparative Study on Characteristics and Cytotoxicity of Bifunctional Magnetic-Silver Nanostructures: Synthesized Using Three Different Reducing Agents

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Acta Metallurgica Sinica (English Letters) Aims and scope

Abstract

Magnetic-silver nanostructures were synthesized via optimized chemical conditions, and their characteristics and cytotoxicity were compared as candidates for the magnetic delivery of silver nanoparticles toward cancer cells. Magnetic-silver nanostructures were prepared through the reduction of silver ions in the presence of iron oxide nanoparticles using three different reducing agents (glucose, maltose and sodium citrate). Their physicochemical characteristics were determined using ultraviolet–visible spectroscopy, X-ray diffraction analysis, transmission electron microscopy, selected area electron diffraction analysis, Fourier transformed infrared spectroscopy, atomic absorption spectroscopy, vibrating sample magnetometry and differential scanning calorimetry. Cytotoxic activities were evaluated against a human liver hepatocellular carcinoma cell line. Fabricated nanostructures, which exhibit differences in size, silver content, magnetic saturation value and cytotoxicity, represent sufficient superparamagnetic properties and considerable cytotoxicity to be suggested as effective tools in magnetic targeting of silver nanoparticles as an approach to cancer therapy.

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Acknowledgments

This work was financially supported by Shiraz University of Medical Sciences, Shiraz, Iran (Grant Number 92-6587).

Author information

Authors and Affiliations

  1. Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Fars, Iran

    Narjes Ebrahimi, Younes Ghasemi & Ahmad Gholami

  2. Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Fars, Iran

    Sara Rasoul-Amini

  3. Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Fars, Iran

    Sara Rasoul-Amini & Younes Ghasemi

  4. Department of Medical Biotechnology, School of Medicine, Fasa University of Medical Sciences, Fasa, Fars, Iran

    Alireza Ebrahiminezhad

  5. Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Fars, Iran

    Hassan Seradj

Authors
  1. Narjes Ebrahimi
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  2. Sara Rasoul-Amini
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  3. Alireza Ebrahiminezhad
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  4. Younes Ghasemi
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  5. Ahmad Gholami
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  6. Hassan Seradj
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Correspondence to Sara Rasoul-Amini.

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Ebrahimi, N., Rasoul-Amini, S., Ebrahiminezhad, A. et al. Comparative Study on Characteristics and Cytotoxicity of Bifunctional Magnetic-Silver Nanostructures: Synthesized Using Three Different Reducing Agents. Acta Metall. Sin. (Engl. Lett.) 29, 326–334 (2016). https://doi.org/10.1007/s40195-016-0399-9

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  • DOI: https://doi.org/10.1007/s40195-016-0399-9

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