Abstract
Purpose of Review
This paper aims to review the available treatment options for spasticity management that can be used for pregnant women with spinal cord injury (SCI).
Recent Findings
There are extensive reviews exploring the approach to care for the parturient with SCI. These often include a discussion on common medications used and their potential impact on pregnancy and lactation. However, there are no specific guidelines on managing spasticity in pregnancy. Existing review articles show a low level of evidence for commonly utilized physical interventions in spasticity management. There are several case reports on the use of intrathecal baclofen and focal injections with botulinum neurotoxin during pregnancy.
Summary
The approach to management should recognize the interaction of pregnancy with secondary complications of SCI. Treatment decisions should be based on severity of spasticity, patient goals, and education of potential risks and benefits of different options with regard to pregnancy, lactation, maternal, and fetal outcomes.
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References
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Adams MM, Hicks AL. Spasticity after spinal cord injury. Spinal Cord. 2005;43(10):577–86.
Holtz KA, Lipson R, Noonan VK, Kwon BK, Mills PB. Prevalence and effect of problematic spasticity after traumatic spinal cord injury. Arch Phys Med Rehabil. 2017;98(6):1132–8.
Burns AS, Lanig I, Grabljevec K, New PW, Bensmail D, Ertzgaard P, et al. Optimizing the management of disabling spasticity following spinal cord damage: the Ability Network—an international initiative. Arch Phys Med Rehabil. 2016;97(12):2222–8.
Pandyan AD, Gregoric M, Barnes MP, Wood D, Wijck FV, Burridge J, et al. Spasticity: clinical perceptions, neurological realities and meaningful measurement. Disabil Rehabil. 2005;27(1–2):2–6.
Burridge JH, Wood DE, Hermens HJ, Voerman GE, Johnson GR, Wijck FV, et al. Theoretical and methodological considerations in the measurement of spasticity. Disabil Rehabil. 2005;27(1–2):69–80.
Lance JW. Symposium synopsis. Spasticity: disorder of motor control. In: Feldman RG, Young RR, editors. Spasticity: disorder of motor control. Chicago: Yearbook Medical Publishers; 1980. p. 485–94.
Rekand T, Hagen EM, Gronning M. Spasticity following spinal cord injury. Tidsskr Nor Laegeforen. 2012;132(8):970–3.
Gorgey AS, Dudley GA. Spasticity may defend skeletal muscle size and composition after incomplete spinal cord injury. Spinal Cord. 2008;46(2):96–102.
Lofvenmark I, Werhagen L, Norrbrink C. Spasticity and bone density after a spinal cord injury. J Rehabil Med. 2009;41(13):1080–4.
Jung IY, Kim HR, Chun SM, Leigh JH, Shin HI. Severe spasticity in lower extremities is associated with reduced adiposity and lower fasting plasma glucose level in persons with spinal cord injury. Spinal Cord. 2017;55:378–378-382.
New PW. Secondary conditions in a community sample of people with spinal cord damage. J Spinal Cord Med. 2016;39(6):665–70.
Tibbett J, Widerstrom-Noga EG, Thomas CK, Field-Fote EC. Impact of spasticity on transfers and activities of daily living in individuals with spinal cord injury. J Spinal Cord Med. 2018;15:1–14.
McKay WB, Sweatman WM, Field-Fote EC. The experience of spasticity after spinal cord injury: perceived characteristics and impact on daily life. Spinal Cord. 2018;56(5):478–86. Epub 2018 Jan 16
National Spinal Cord Injury Statistical Center, ed. Spinal cord injury facts and figures at a glance. Birmingham, AL: University of Alabama at Birmingham; 2018.
National Spinal Cord Injury Statistical Center. Spinal cord injury model systems 2016 annual report—public version. 2016:15.
Jackson AB, Wadley V. A multicenter study of women's self-reported reproductive health after spinal cord injury. Arch Phys Med Rehabil. 1999;80(11):1420–8.
• Iezzoni LI, Chen Y, McLain AB. Current pregnancy among women with spinal cord injury: findings from the US national spinal cord injury database. Spinal Cord. 2015;53(11):821–6. This cross-sectional study represents data from 1907 women with SCI. Current pregnancy rates among reproductive-aged women with SCI were found to be similar to rates of other US women with and without chronic mobility impairments (after adjusting for age differences).
Baker ER, Cardenas DD. Pregnancy in spinal cord injured women. Arch Phys Med Rehabil. 1996;77(5):501–7.
Ghidini A, Healey A, Andreani M, Simonson MR. Pregnancy and women with spinal cord injuries. Acta Obstet Gynecol Scand. 2008;87(10):1006–10.
Ghidini A, Simonson MR. Pregnancy after spinal cord injury: a review of literature. Topics in Spinal Cord Injury Rehabilitation. 2011;16(3):93–103.
Sterling L, Keunen J, Wigdor E, Sermer M, Maxwell C. Pregnancy outcomes in women with spinal cord lesions. J Obstet Gynaecol Can. 2013;35(1):39–43.
Dawood R, Altanis E, Ribes-Pastor P, Ashworth F. Pregnancy and spinal cord injury. Obstet Gynecol. 2014;16:99–107.
Camune BD. Challenges in the management of the pregnant woman with spinal cord injury. J Perinat Neonatal Nurs. 2013;27(3):225–31.
Signore C, Spong CY, Krotoski D, Shinowara NL, Blackwell SC. Pregnancy in women with physical disabilities. Obstet Gynecol. 2011;117(4):935–47.
Bertschy S, Bostan C, Meyer T, Pannek J. Medical complications during pregnancy and childbirth in women with SCI in Switzerland. Spinal Cord. 2016;54(3):183–7.
Tan EK, Tan EL. Alterations in physiology and anatomy during pregnancy. Best Pract Res Clin Obstet Gynaecol. 2013;27(6):791–802.
Talbot L, Maclennan K. Physiology of pregnancy. Anaesthesia and Intensive Care Medicine. 2016;17(7):341–5.
• Le Liepvre H, Dinh A, Idiard-Chamois B, et al. Pregnancy in spinal cord-injured women, a cohort study of 37 pregnancies in 25 women. Spinal Cord. 2017;55(2):167–71. This is a retrospective observational study of 25 women (37 pregnancies). Main complications include UTIs, pyelonephritis, pressure sores.
Baker ER, Cardenas DD, Benedetti TJ. Risks associated with pregnancy in spinal cord-injured women. Obstet Gynecol. 1992;80(3 Pt 1):425–8.
Iezzoni LI, Wint AJ, Smeltzer SC, Ecker JL. Effects of disability on pregnancy experiences among women with impaired mobility. Acta Obstet Gynecol Scand. 2015;94(2):133–40.
Oshima S, Kirschner KL, Heinemann A, Semik P. Assessing the knowledge of future internists and gynecologists in caring for a woman with tetraplegia. Arch Phys Med Rehabil. 1998;79(10):1270–6.
American College of Obstetricians and Gynecologists. ACOG committee opinion: number 275, September 2002. Obstetric management of patients with spinal cord injuries. Obstet Gynecol. 2002;100(3):625–7.
McLain AB, Massengill T, Klebine P. Information/education page. Pregnancy and women with spinal cord injury. Arch Phys Med Rehabil. 2016;97(3):497–8.
SCI Fact Sheets: pregnancy and women with spinal cord injury. Model systems knowledge translation center. https://msktc.org/sci/factsheets/pregnancy-and-women-spinal-cord-injury. May 2015. Accessed April 14, 2018.
Pregnancy and spinal cord injury an information booklet for women with SCI. https://scisexualhealth.ca/female-fertility-and-pregnancy/. Updated 2015. Accessed April 14, 2018.
• Lanig IS, New PW, Burns AS, et al. Optimizing the management of spasticity in people with spinal cord damage: a clinical care pathway for assessment and treatment decision making from the Ability Network, an international initiative. Arch Phys Med Rehabil. 2018;99(8):1681–7. This describes a clinical care pathway to guide assessment and treatment of disabling spasticity in adults.
Nene AV, Rainha Campos A, Grabljevec K, Lopes A, Skoog B, Burns AS. Clinical assessment of spasticity in people with spinal cord damage: recommendations from the ability network, an international initiative. Arch Phys Med Rehabil. 2018;99 (9):1917–26. https://doi.org/10.1016/j.apmr.2018.01.018.
• Andretta E, Landi LM, Cianfrocca M, Manassero A, Risi O, Artuso G. Bladder management during pregnancy in women with spinal-cord injury: an observational, multicenter study. Int Urogynecol J. 2018. https://doi.org/10.1007/s00192-018-3620-8. This cross-sectional survey of 52 women with SCI (representing 67 pregnancies) describes management of neurogenic bladder, focusing on increased awareness of bladder issues and changes in bladder management during pregnancy.
Pannek J, Bertschy S. Mission impossible? Urological management of patients with spinal cord injury during pregnancy: a systematic review. Spinal Cord. 2011;49(10):1028–32.
Salomon J, Schnitzler A, Ville Y, Laffont I, Perronne C, Denys P, et al. Prevention of urinary tract infection in six spinal cord-injured pregnant women who gave birth to seven children under a weekly oral cyclic antibiotic program. Int J Infect Dis. 2009;13(3):399–402.
• Michau A, Dinh A, Denys P, et al. Control cross-sectional study evaluating an antibiotic prevention strategy in 30 pregnancies under clean intermittent self-catheterization and review of literature. Urology. 2016;91:58–63. This is a cross-sectional study of 25 women (30 pregnancies). Participants who received weekly oral cyclic antibiotic strategy to prevent UTIs showed lower incidence of UTIs, cystitis but higher colonization rates. No significant increase in adverse fetal outcomes were reported.
Smania N, Picelli A, Munari D, Geroin C, Ianes P, Waldner A, et al. Rehabilitation procedures in the management of spasticity. Eur J Phys Rehabil Med. 2010;46(3):423–38.
• Khan F, Amatya B, Bensmail D, Yelnik A. Non-pharmacological interventions for spasticity in adults: an overview of systematic reviews. Ann Phys Rehabil Med 2017. This review evaluated evidence from 18 systematic reviews. Low quality evidence for rehabilitation programs targeting spasticity, including vibration therapy for SCI and stretching for other neurologic conditions.
Harvey LA, Katalinic OM, Herbert RD, Moseley AM, Lannin NA, Schurr K. Stretch for the treatment and prevention of contractures. Cochrane Database Syst Rev. 2017;1:CD007455.
Bovend'Eerdt TJ, Newman M, Barker K, Dawes H, Minelli C, Wade DT. The effects of stretching in spasticity: a systematic review. Arch Phys Med Rehabil. 2008;89(7):1395–406.
Stevenson VL. Rehabilitation in practice: spasticity management. Clin Rehabil. 2010;24(4):293–304.
Nakhostin Ansari N, Naghdi S, Hasson S, Rastgoo M. Efficacy of therapeutic ultrasound and infrared in the management of muscle spasticity. Brain Inj. 2009;23(7):632–8.
Sahin N, Ugurlu H, Karahan AY. Efficacy of therapeutic ultrasound in the treatment of spasticity: a randomized controlled study. NeuroRehabilitation. 2011;29(1):61–6.
Borg-Stein J, Dugan SA, Gruber J. Musculoskeletal aspects of pregnancy. Am J Phys Med Rehabil. 2005;84(3):180–92.
Mills PB, Dossa F. Transcutaneous electrical nerve stimulation for management of limb spasticity: a systematic review. Am J Phys Med Rehabil. 2016;95(4):309–18.
Oo WM. Efficacy of addition of transcutaneous electrical nerve stimulation to standardized physical therapy in subacute spinal spasticity: a randomized controlled trial. Arch Phys Med Rehabil. 2014;95(11):2013–20.
Sivaramakrishnan A, Solomon JM, Manikandan N. Comparison of transcutaneous electrical nerve stimulation (TENS) and functional electrical stimulation (FES) for spasticity in spinal cord injury—a pilot randomized cross-over trial. J Spinal Cord Med 2018;41(4): 397–06.
Keskin EA, Onur O, Keskin HL, Gumus II, Kafali H, Turhan N. Transcutaneous electrical nerve stimulation improves low back pain during pregnancy. Gynecol Obstet Investig. 2012;74(1):76–83.
Crothers E, Coldron Y, Cook T, Watson T, Notcutt W. Safe use of transcutaneous electrical nerve stimulation for musculoskeletal pain during pregnancy. ACPWH Journal. 2012;111:22–6.
Hsieh JT, Wolfe DL, Connolly S, et al. Spasticity after spinal cord injury: an evidence based review of current interventions. Top Spinal Cord Inj Rehabil. 2007;13(1):81–97.
Kesiktas N, Paker N, Erdogan N, Gulsen G, Bicki D, Yilmaz H. The use of hydrotherapy for the management of spasticity. Neurorehabil Neural Repair. 2004;18(4):268–73.
da Silva JR, Borges PS, Agra KF, Pontes IA, Alves JG. Effects of an aquatic physical exercise program on glycemic control and perinatal outcomes of gestational diabetes: study protocol for a randomized controlled trial. Trials. 2013;14:390. https://doi.org/10.1186/1745-6215-14-390.
Barakat R, Perales M, Cordero Y, Bacchi M, Motolla M. Influence of land or water exercise in pregnancy on outcomes: a cross-sectional study. Med Sci Sports Exerc. 2017;49(7):1397–403.
Schrepfer R. Aquatic exercise. In: Kisner C, Colby LA, editors. Therapeutic exercise foundations and techniques. 5th ed. Philadelphia: F.A. Davis Company; 2007. p. 276–7.
Ward EJ, McIntyre A, van Kessel G, Hague WM. Immediate blood pressure changes and aquatic physiotherapy. Hypertens Pregnancy. 2005;24(2):93–102.
Naro A, Leo A, Russo M, Casella C, Buda A, Crespantini A, et al. Breakthroughs in the spasticity management: are non-pharmacological treatments the future? J Clin Neurosci. 2017;39:16–27.
Geigle PR, Kallins M. Exoskeleton-assisted walking for people with spinal cord injury. Arch Phys Med Rehabil. 2017;98(7):1493–5.
EKSO GT Bionic Operating Manual 2013:5.
Gracies JM, Nance P, Elovic E, McGuire J, Simpson DM. Traditional pharmacological treatments for spasticity. Part II: general and regional treatments. Muscle Nerve Suppl. 1997;6:S92–120.
Micromedex® (electronic version). http://www.micromedexsolutions.com.ezp.welch.jhmi.edu/. Updated April 2018. Accessed 04/20, 2018.
U.S. Food and Drug Administration. Pregnancy and lactation labeling rule. https://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/Labeling/ucm093307.htm. Updated 02/08/2018. Accessed 04/24/2018.
Guttuso T, Shaman M Jr, Thornburg LL. Potential maternal symptomatic benefit of gabapentin and review of its safety in pregnancy. Eur J Obstet Gynecol Reprod Biol. 2014;181:280–3.
Bradley LJ, Kirker SGB. Pregabalin in the treatment of spasticity: a retrospective case series. Disabil Rehabil: An International, Multidisciplinary Journal. 2008;30(16):1230–1230-1232.
Edwards JA, Reid YJ, Cozens DD. Reproductive toxicity studies with oxybutynin hydrochloride. Toxicology. 1986;40(1):31–44.
Walker HW, Lee MY, Bahroo LB, Hedera P, Charles D. Botulinum toxin injection techniques for the management of adult spasticity. PM R. 2015;7(4):417–27.
Syme MR, Paxton JW, Keelan JA. Drug transfer and metabolism by the human placenta. Clin Pharmacokinet. 2004;43(8):487–514.
Lange DJ, Brin MF, Warner CL, Fahn S, Lovelace RE. Distant effects of local injection of botulinum toxin. Muscle Nerve. 1987;10(6):552–5.
Aranda MA, Herranz A, del Val J, Bellido S, Garcia-Ruiz P. Botulinum toxin A during pregnancy, still a debate. Eur J Neurol. 2012;19(8):e81–2.
Bodkin CL, Maurer KB, Wszolek ZK. Botulinum toxin type A therapy during pregnancy. Mov Disord. 2005;20(8):1081–2.
de Oliveira Monteiro E. Botulinum toxin and pregnancy. Skinmed. 2006;5(6):308.
Krug H, Krause P, Kupsch A, Kühn AA. Safe administration of botulinum toxin type a injections during pregnancy: a report of two cases. Movement Disorders Clinical Practice. 2015;2(2):187–9.
Li Yim JF, Weir CR. Botulinum toxin and pregnancy—a cautionary tale. Strabismus. 2010;18(2):65–6.
Newman W, Davis T, Padaliya B, et al. Botulinum toxin type A therapy during pregnancy. Mov Disord. 2004;19(11):1384–5.
Moser E, Ligon K, Singer C, Sethi K. Botulinum toxin A (Botox) therapy during pregnancy. Neurology. 1997;48(3):69008.
Tan M, Kim E, Koren G, Bozzo P. Botulinum toxin type A in pregnancy. Can Fam Physician. 2013;59(11):1183–4.
Morgan JC, Iyer SS, Moser ET, Singer C, Sethi KD. Botulinum toxin A during pregnancy: a survey of treating physicians. J Neurol Neurosurg Psychiatry. 2006;77(1):117–9.
• Brin MF, Kirby RS, Slavotinek A, et al. Pregnancy outcomes following exposure to onabotulinumtoxinA. Pharmacoepidemiol Drug Saf. 2016;25(2):179–87. This is a 24 year retrospective review of the Allergan safety database. Two hundred thirty-two pregnancies were eligible with known outcomes. In this study, the prevalence of fetal defects in onabotulinum toxin A exposed mothers before/during pregnancy (2.7%) is comparable with background rates in the general population.
Heetla HW, Staal MJ, Proost JH, van Laar T. Clinical relevance of pharmacological and physiological data in intrathecal baclofen therapy. Arch Phys Med Rehabil. 2014;95(11):2199–206.
Morton CM, Rosenow J, Wong C, Kirschner KL. Intrathecal baclofen administration during pregnancy: a case series and focused clinical review. PM R. 2009;1(11):1025–9.
Tandon SS, Hoskins I, Azhar S. Intrathecal baclofen pump—a viable therapeutic option in pregnancy. Obstet Med. 2010;3(3):119–20.
DeVries-Rizzo M, Warren D, Delaney G, Levin S, Campbell C, DeRibaupierre S. Intrathecal baclofen and pregnancy: implications for clinical care. Can J Neurosci Nurs. 2009;31(3):21–4.
Dalton CM, Keenan E, Jarrett L, Buckley L, Stevenson VL. The safety of baclofen in pregnancy: intrathecal therapy in multiple sclerosis. Mult Scler. 2008;14(4):571–2.
Roberts AG, Graves CR, Konrad PE, Groomes TE, Pfister AA, Damian MM, et al. Intrathecal baclofen pump implantation during pregnancy. Neurology. 2003;61(8):1156–7.
Munoz FC, Marco DG, Perez AV, Camacho MM. Pregnancy outcome in a woman exposed to continuous intrathecal baclofen infusion. Ann Pharmacother. 2000;34(7–8):956.
Delhaas EM, Verhagen J. Pregnancy in a quadriplegic patient treated with continuous intrathecal baclofen infusion to manage her severe spasticity. Case report. Paraplegia. 1992;30(7):527–8.
Duncan SD, Devlin LA. Use of baclofen for withdrawal in a preterm infant. J Perinatol. 2013;33:327–8.
Ratnayaka BD, Dhaliwal H, Watkin S. Drug points: neonatal convulsions after withdrawal of baclofen. BMJ. 2001;323(7304):85.
Lin H, Barton N, Wiegand T. Prevention of neonatal abstinence syndrome in the setting of intrauterine baclofen exposure. Journal of Medical Toxicology. 2014;10:85–6.
Abrams DI. The therapeutic effects of cannabis and cannabinoids: an update from the national academies of sciences, engineering and medicine report. Eur J Intern Med. 2018;49:7–11.
Pooyania S, Ethans K, Szturm T, Casey A, Perry D. A randomized, double-blinded crossover pilot study assessing the effect of nabilone on spasticity in persons with spinal cord injury. Arch Phys Med Rehabil. 2010;91:703–7.
Hagenbach U, Luz S, Ghafoor N, Berger JM, Grotenhermen F, Brenneisen R, et al. The treatment of spasticity with delta 9-tetrahydrocannabinol in persons with spinal cord injury. Spinal Cord. 2007;45:551–62.
Hawley LA, Ketchum JM, Morey C, Collins K, Charlifue S. Cannabis use in individuals with spinal cord injury or moderate to severe traumatic brain injury in Colorado. Arch Phys Med Rehabil. 2018; 99(8):1584–90. https://doi.org/10.1016/j.apmr.2018.02.003. Accessed 04/24/2018.
Drossel C, Forchheimer M, Meade M. Characteristics of individuals with spinal cord injury who use cannabis for therapeutic purposes. Top Spinal Cord Inj Rehabil. 2016;22(1):3–12.
Committee on Obstetric Practice. Committee opinion no. 722: marijuana use during pregnancy and lactation. Obstet Gynecol. 2017;130(4):e205–9.
Metz T, Stickrath E. Marijuana use in pregnancy and lactation: a review of the evidence. Am J Obstet Gynecol. 2015;213(6):761–8.
Mark K, Terplan M. Cannabis and pregnancy: maternal child health implications during a period of drug policy liberalization. Prev Med. 2017;104:46–9.
Andresen S, Biering-Sorensen F, Hagen E, Nielsen J, Bach F, Finnerup N. Cannabis use in persons with traumatic spinal cord injury in Denmark. J Rehabil Med. 2017;49:152–60.
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Cabahug, P.G. Managing Spasticity in a Pregnant Woman with Spinal Cord Injury: a Review. Curr Phys Med Rehabil Rep 6, 245–256 (2018). https://doi.org/10.1007/s40141-018-0198-5
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DOI: https://doi.org/10.1007/s40141-018-0198-5