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Molecular Biomarkers for Glaucoma

  • Diagnosis and Monitoring of Glaucoma (J Kammer, Section Editor)
  • Published:
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Abstract

Purpose of Review

This article summarizes the current studies on molecular biomarkers with potential implications in diagnosis, prognosis, and response to treatment in patients with glaucoma.

Recent Findings

Important advances have occurred in the understanding of the pathogenesis of glaucomatous neurodegeneration. Protein biomarkers associated with inflammatory, neurodegenerative, and other molecular pathways have been described in glaucoma patients in tear film, aqueous fluid, vitreous fluid, and serum, however, we are still far from having a clear picture of the whole molecular network that relates to the disease and its implications in clinical use.

Summary

Although more studies are needed, current and emerging molecular biomarkers candidates in glaucoma may eventually transition into clinical use and contribute to outline the concept of precision medicine and precision health in glaucoma.

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Acknowledgments

We gratefully acknowledge the National Eye Institute (P30-EY026877), the Glaucoma Research Foundation, and Research to Prevent Blindness, Inc.

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Authors and Affiliations

  1. Byers Eye Institute at Stanford University, 2452 Watson Ct, Palo Alto, CA, 94303, USA

    Gala Beykin & Jeffrey L. Goldberg

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  1. Gala Beykin
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This article is part of the Topical Collection on Diagnosis and Monitoring of Glaucoma

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Beykin, G., Goldberg, J.L. Molecular Biomarkers for Glaucoma. Curr Ophthalmol Rep 7, 171–176 (2019). https://doi.org/10.1007/s40135-019-00213-0

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