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Cyanobacterial Secondary Metabolite Scytonemin: A Potential Photoprotective and Pharmaceutical Compound

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Abstract

Scytonemin is a lipid-soluble, highly stable, yellow–brown-coloured secondary metabolite that is accumulated in the extracellular polysaccharide sheath of several but not all members of cyanobacteria. Chemically, scytonemin is an indole alkaloid composed of two heterocyclic units symmetrically connected through a carbon–carbon bond. Thus, scytonemin is unique among natural products due to its special structure, location in a cell, as well as strong absorption maxima in UV-A in addition to the violet–blue region. Traditionally, scytonemin is a well-established photoprotective compound against ultraviolet radiation. Its accumulation in the cyanobacterial sheath has been suggested to be a strategy adopted by several cyanobacteria to protect their cellular components against damaging effects of UVR. Additionally, recent studies have also established the importance of scytonemin in reactive oxygen species scavenging as well as in controlling the growth of cancerous cells. Thus, scytonemin is both ecologically as well as pharmaceutically important metabolite. Recent developments made in the biochemistry and genetics of this compound have paved the way for its application and commercialization for human welfare. This review aims to present a brief history of the compound with chronological developments made in the study of scytonemin and emphasizes its physiochemistry, analytical chemistry, biochemistry, and genetics. We provide a separate section for metabolic engineering and potential applications of scytonemin, mainly as sunscreen and anti-cancerous drugs. We also discuss the future research directions which need to be worked out.

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Acknowledgements

J. Pathak (09/013/0515/2013-EMR-I) and A. Pandey (09/013/0619/2016-EMR-I) are thankful to the Council of Scientific and Industrial Research, New Delhi, India. Rajneesh is grateful to Department of Biotechnology, Govt. of India, (DBT-JRF/13/AL/143/2158), for the grant in the form of senior research fellowships. P.K. Maurya (3616/NET-DEC2014) is thankful to University Grant commission (UGC), New Delhi, India, for financial support in the form of JRF. S.P. Singh acknowledges the UGC for start-up Grant (F.30-370/2017; BSR) and DST-SERB for early career research Award (ECR/2016/000578).

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Authors and Affiliations

  1. Laboratory of Photobiology and Molecular Microbiology, Centre of Advanced Study in Botany, Institute of Science, Banaras Hindu University, Varanasi, 221005, India

    Jainendra Pathak, Abha Pandey, Rajneesh Rajneesh & Rajeshwar P. Sinha

  2. Centre of Advanced Study in Botany, Institute of Science, Banaras Hindu University, Varanasi, 221005, India

    Pankaj K. Maurya & Shailendra P. Singh

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  1. Jainendra Pathak
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  4. Rajneesh Rajneesh
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  6. Shailendra P. Singh
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Contributions

JP and SPS conceptualized the idea, did the literature survey, and wrote the paper; Rajneesh, AP, and PM developed the figures and tables; and RPS and SPS edited the manuscript.

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Correspondence to Shailendra P. Singh.

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Significance Statement This review highlights the recent advancements made in the study of a cyanobacterial photoprotective compound called scytonemin. The biochemistry and genetics of scytonemin production have been discussed in detail. The roadmap for scytonemin production using metabolically engineered strains and rate-limiting steps for scytonemin biosynthesis have been presented. Also, it emphasizes the various application of scytonemin in different industries for human welfare.

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Pathak, J., Pandey, A., Maurya, P.K. et al. Cyanobacterial Secondary Metabolite Scytonemin: A Potential Photoprotective and Pharmaceutical Compound. Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. 90, 467–481 (2020). https://doi.org/10.1007/s40011-019-01134-5

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