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Assessment of Toothpaste Formulations Containing Turmeric and Neem Extract for Prevention of Dental Caries and Periodontal Diseases

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Proceedings of the National Academy of Sciences, India Section B: Biological Sciences Aims and scope Submit manuscript

Abstract

In the present work, toothpastes were prepared for preventing dental caries and periodontal diseases. Nine formulations (TN1 to TN9) were prepared using neem extract and turmeric powder as active principles. These prepared formulations were evaluated for homogeneity, spreadability, fineness, pH, foaming power, tube extrudability, and stability as per the guidelines of the Bureau of Indian Standards and in-vitro antimicrobial activity. The in-vitro antimicrobial activity studies were performed using standard strains such as Candida albicans (ATCC No. 10231), Streptococcus mutans (MTCC No. 497) and Porphyromonas gingivalis (oral gingival swab). A comparative evaluation of the promising toothpaste formulations against selected marketed toothpastes was also carried out. Among the nine prepared formulations TN1 to TN9 (different concentrations of neem and turmeric powder), formulation TN3 (toothpaste containing 0.5% of neem extract and 0.9% of turmeric powder) has shown promising results (inhibition zone diameters of 23.5, 22.5 and 19.5 mm respectively against C. albicans, S. mutans and P. gingivalis). TN3 emerged as the overall best formulation indicating their potential usefulness in preventing various dental problems.

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Acknowledgements

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. D.S.T.S.Mandal’s College of Pharmacy, Solapur, Maharastra, 413004, India

    Baburao N. Chandakavathe & Shivsharan B. Dhadde

  2. H.K.E. Society’s College of Pharmacy, Gulbarga, Karnataka, 585 105, India

    Deepak K. Deshpande & P. V. Swamy

Authors
  1. Baburao N. Chandakavathe
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  2. Deepak K. Deshpande
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  3. P. V. Swamy
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  4. Shivsharan B. Dhadde
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Correspondence to Baburao N. Chandakavathe.

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Significance statement

Dental caries and periodontal diseases are the major oral health problems in the world. Toothpaste preparation containing herbs plays very important role in the prevention and treatment of various dental and periodontal diseases. Present study data suggests that use of herbs like turmeric and neem in the toothpaste preparation is effective solution for such oral health problems.

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Chandakavathe, B.N., Deshpande, D.K., Swamy, P.V. et al. Assessment of Toothpaste Formulations Containing Turmeric and Neem Extract for Prevention of Dental Caries and Periodontal Diseases. Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. 88, 1523–1529 (2018). https://doi.org/10.1007/s40011-017-0897-1

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  • DOI: https://doi.org/10.1007/s40011-017-0897-1

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