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Distribution of “molybdenum disulfide/cobalt ferrite” nanocomposite in animal model of breast cancer, following injection via differential infusion flow rates

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Abstract

Purpose

Aims were to investigate pattern of distribution of “molybdenum disulfide/cobalt ferrite” magnetic nanocomposite (MNC), following injection into the BALB/c mice tumor.

Methods

MNCs were characterized by microscopic, spectroscopic and magneto-metric techniques. To have a gland tumor, 4T1 cells injected subcutaneously. After 1 week of tumor growth, MNCs injected to the tumor at different speed rates, and tumor size monitored after magnetic fluid hyperthermia (MFH) by seven days via measurement of tumors’ outer dimensions, histopathology and qRT-PCR assay techniques.

Results

Neither MoS2/CoFe2O4 nor applied alternative magnetic field (AMF) diminished viability of tumor cells. However, when concentration of 200 µg/ml injected by speed rate of 10 µl/min to the tumor in the presence of AMF (f = 150 kHz, H = 31.16 mT), significant diminution of tumor size and considerable raise of tumor necrosis observed. At the same time, up-regulation of Bax and p53, and down-regulation of VEGF and Bcl2 was detected.

Conclusion

Uniform distribution of MNC in optimized condition resulted in significant diminution of tumor size after MFH. Besides, injection of MoS2/CoFe2O4 to the tumor left no sign of necrosis or inflammation in the mice liver. These features of MoS2/CoFe2O4 introduce it as a promising candidate for further clinical studies.

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Acknowledgements

The authors wish to thank Dr. Alireza Naderi Sohi for his insightful comments.

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Authors and Affiliations

  1. Department of Mechanical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Mohammadhossein Shahsavari Alavijeh, Adel Maghsoudpour & Morteza Khayat

  2. Stem Cell Technology Research Center, Tehran, Iran

    Iman Rad & Shadie Hatamie

  3. Institute of Nano Engineering and MicroSystems National Tsing Hua University, Hsinchu, 30013, Taiwan

    Shadie Hatamie

Authors
  1. Mohammadhossein Shahsavari Alavijeh
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  2. Adel Maghsoudpour
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  3. Morteza Khayat
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  4. Iman Rad
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  5. Shadie Hatamie
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Corresponding authors

Correspondence to Adel Maghsoudpour or Morteza Khayat.

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Statement of human and animal rights

The animal studies were performed after receiving approval of the Institutional Animal Care and Use Committee (IACUC) of the Tehran university of medical sciences (IACUC protocol number: 93-02-45-26666).

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Shahsavari Alavijeh, M., Maghsoudpour, A., Khayat, M. et al. Distribution of “molybdenum disulfide/cobalt ferrite” nanocomposite in animal model of breast cancer, following injection via differential infusion flow rates. J. Pharm. Investig. 50, 583–592 (2020). https://doi.org/10.1007/s40005-020-00479-8

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