Abstract
We report the sorption evaluation method for injectable drugs administered using set tubes to evaluate the quality of the administration sets. The evaluation method using a peristaltic pump, so called pump method, was used for the kinetic sorption study. Nitroglycerin (NTG) and cyclosporin A (CSA) were selected as model drugs. The parameters of drug-diluted concentrations and flow rates were adapted to the clinically relevant values. Polyvinylchloride (PVC)- and non-PVC (PU and PO)-based tubes were cut to a fixed length of 1 m after removing the accessories in the administration sets. NTG and CSA were analyzed using high-performance liquid chromatography (HPLC) methods with ultraviolet (UV) detection. After the drug analyses, NTG and CSA sorption levels were calculated from the percentage values of the subtracted drug concentrations in samples from those in the diluted solutions. The average sorption levels and each sorption level at each sampling point were considered to compare the sorption levels in all administration set tubes. Both drugs showed high sorption levels in PVC- and PU-based administration set tubes. However, the drugs showed a minimum sorption potential of < 10% on PO-based tubes, which could be clinically acceptable. This suggests that the sorption evaluation methods for NTG and CSA could be promising standards for endorsing administration set tubes and for evaluating newly developed or designed polymeric alternatives. Additionally, PO could be an alternative and next-generation polymeric material for manufacturing administration set tubes.
Similar content being viewed by others
References
Arruda WO, Brito Filho D, Rosa SL et al (1989) Factors affecting diazepam availability from intravenous admixture solutions. Arq Neuropsiquiatr 47:291–294
Cheng WP, Gray AI, Tetley L et al (2006) Polyelectrolyte nanoparticles with high drug loading enhance the oral uptake of hydrophobic compounds. Biomacromolecules 7:1509–1520
Jenke DR (1993a) Evaluation of various solvent systems for modeling solute sorption with plasticized polyvinyl chloride materials. J Pharm Sci 82:617–621
Jenke DR (1993b) Modeling of solute sorption by polyvinyl chloride plastic infusion bags. J Pharm Sci 82:1134–1139
Jin SE, You S, Jeon S et al (2016) Diazepam sorption to PVC- and non-PVC-based tubes in administration sets with quantitative determination using a high-performance liquid chromatographic method. Int J Pharm 506:414–419
Jin SE, Jeon S, Byon HJ et al (2017a) Evaluation of tacrolimus sorption to PVC- and non-PVC-based tubes in administration sets: pump method vs. drip method. Int J Pharm 528:172–179
Jin SE, You S, Jeon S et al. (2017b) Evaluation of drug sorption to PVC- and non-PVC-based tubes in administration sets using a pump. J Vis Exp 121
Kambia NK, Dine T, Dupin-Spriet T et al (2005) Compatibility of nitroglycerin, diazepam and chlorpromazine with a new multilayer material for infusion containers. J Pharm Biomed Anal 37:259–264
Kawano K, Tsubouchi R, Nakajima S (1992) The effect of the drip condition (container materials, concentration, drip Rate) on the sorption of nicardipine hydrochloride from injection to the intravenous infusion set. Jpn J Hosp Pharm 18:491–495
Kowaluk EA, Roberts MS, Polack AE (1986) Kinetics of sorption of ionizable solutes by plastic infusion bags. J Pharm Sci 75:562–570
Krzek J, Moniczewska M, Zabierowska-Ślusarczyk G (2003) The HPLC determination of propane-1,2,3-triyl trinitrite and impurities: (2RS)-3-hydroxypropane-1,2-diyl dinitrate and 2-hydroxypropane-1,3-diyl dinitrate in ointment. J Pharm Biomed Anal 33:403–409
Martens HJ, De Goede PN, Van Loenen AC (1990) Sorption of various drugs in polyvinyl chloride, glass, and polyethylene-lined infusion containers. Am J Hosp Pharm 47:369–373
Morar-Mitrica S, Puri M, Beumer Sassi A et al (2015) Development of a stable low-dose aglycosylated antibody formulation to minimize protein loss during intravenous administration. mAbs 7:792–803
Ritschel WA, Ritschel GB, Sabouni A et al (1989) Study on the peroral absorption of the endekapeptide cyclosporine A. Methods Find Exp Clin Pharmacol 11:281–287
Roberts MS (1996) Modeling solute sorption into plastic tubing during organ perfusion and intravenous infusions. J Pharm Sci 85:655–665
Roberts MS, Kowaluk EA, Polack AE (1991) Prediction of solute sorption by polyvinyl chloride plastic infusion bags. J Pharm Sci 80:449–455
Schaber DE, Uden DL, McCoy HG (1985) Nitroglycerin adsorption to a combination polyvinyl chloride, polyethylene intravenous administration set. Drug Intell Clin Pharm 19:572–575
Shibata N, Ikuno Y, Tsubakimoto Y et al (2000) Adsorption and pharmacokinetics of cyclosporin A in relation to mode of infusion in bone marrow transplant patients. Bone Marrow Transplant 25:633–638
Sruthi A, Tejaswi P, Thanuja N et al (2013) Simple RP-HPLC method for estimation of diazepam in tablet dosage form. J Pharm Res 6:140–144
Szerkus O, Wolska E, Struck-Lewicka W et al (2014) Development and validation of UHPLC method for the determination of cyclosporine A in biological samples. Biomed Chromatogr 28:802–809
Tamura S, Ohike A, Ibuki R et al (2002) Tacrolimus is a class II low-solubility high-permeability drug: the effect of P-glycoprotein efflux on regional permeability of tacrolimus in rats. J Pharm Sci 91:719–729
Treleano A, Wolz G, Brandsch R et al (2009) Investigation into the sorption of nitroglycerin and diazepam into PVC tubes and alternative tube materials during application. Int J Pharm 369:30–37
Trissel LA, Xu QA, Baker M (2006) Drug compatibility with new polyolefin infusion solution containers. Am J Health Syst Pharm 63:2379–2382
Acknowledgements
This work was supported by the Korea Ministry of Environment through “The Advancement of Scientific Research and Technological Development in Environmental Science Program” (E315-00015-0414-2).
Author information
Authors and Affiliations
Contributions
SEJ designed the study and wrote the paper, JWP performed the experiments and analyzed the data, HB and SWP designed the study and provided comments, SJ designed the study and provided the administration sets, and SJH designed the study as a principal investigator and confirmed the written paper.
Corresponding authors
Ethics declarations
Conflict of interest
The authors declare no conflict of interest.
Research involving human and animal rights
This article does not contain any studies with human and animal subjects performed by any of the authors.
Rights and permissions
About this article
Cite this article
Jin, SE., Park, J.W., Baek, H. et al. Evaluation of nitroglycerin and cyclosporin A sorption to polyvinylchloride- and non-polyvinylchloride-based tubes in administration sets. J. Pharm. Investig. 48, 665–672 (2018). https://doi.org/10.1007/s40005-017-0364-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s40005-017-0364-2