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Deep learning: from chemoinformatics to precision medicine

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Abstract

Deep learning is a new machine learning paradigm that focuses on learning with deep hierarchical models of data. Chemoinformatics has been defined as the mixing of chemical information resources to transform into knowledge for the intended purpose of making better and faster decisions in the area of drug lead identification and optimization. Precision medicine includes disease prevention and treatment strategies that consider individual variability in healthcare. Researchers are now focusing on the convergence of genomics, epigenomics, metabolomics, informatics, and imaging, along with other technologies such as data mining, deep learning, and big data methodology; disciplines that are rapidly expanding the scope of precision medicine. Drug and diagnostic developers, physicians, health systems, and patients share interests in precision medicine. In this review, we provide an overview of recent studies on the application of the deep learning method in the pharmaceuticals and precision medicine fields. We briefly review the fields related to the history of deep learning, chemoinformatics, drug development, model based medicine, electronic healthcare records, wearable sensors, drug response variability, and precision medicine.

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Acknowledgements

This research was supported by the Basic Science Research Program (2014R1A1A2055734) through the National Research Foundation of Korea (NRF) funded by the Ministry of Education and the Korea Health technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HC15C1045).

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  1. College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea

    In-Wha Kim & Jung Mi Oh

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  1. In-Wha Kim
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  2. Jung Mi Oh
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Correspondence to Jung Mi Oh.

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All authors (I.-W. Kim and J.M. Oh) declare that they have no competing interests.

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Kim, IW., Oh, J.M. Deep learning: from chemoinformatics to precision medicine. Journal of Pharmaceutical Investigation 47, 317–323 (2017). https://doi.org/10.1007/s40005-017-0332-x

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