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Effects of absorbent materials on a self-emulsifying drug delivery system for a poorly water soluble drug

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Abstract

In order to compare the effects of a solid carrier on the formulation of a solid self-microemulsifying drug delivery system (s-SMEDDS), a liquid SMEDDS was prepared with simvastatin. The SMEDDS was optimized using polyoxyl 35 castor oil [Kolliphor® EL] as a surfactant (S), diethylene glycol monoethylether [Transcutol® P] as a co-surfactant (C), and prophyleneglycol monocaprylate [Capryol 90] as the oil phase (O). The microemulsion area at the surfactant to co-surfactant ratio (1:1) was evaluated, and the SMEDDS at an S and C/O ratio of 7:3 was selected. Four types of adsorbents with high specific areas were used: Aerosil® 200, Sylysia® 350, Neusilin® US2, Neusilin® UFL2. SEM, DSC, and PXRD results revealed rough-surfaced particles that represent the amorphous state of s-SMEDDS. The optimized formulation with Neusilin® UFL2 markedly improved drug release. The present study concluded that s-SMEDDS was effectively formulated via adsorption with solid carriers.

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Acknowledgments

All authors (J.-B. Park, B.-K. Choi, C.-Y. Kang) have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This article does not contain any studies with human and animal subjects performed by any of the authors.

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  1. College of Pharmacy, Sahmyook University, Seoul, 139-742, South Korea

    Jun-Bom Park, Byoung-Kyu Choi & Chin-Yang Kang

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  1. Jun-Bom Park
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  2. Byoung-Kyu Choi
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  3. Chin-Yang Kang
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Correspondence to Chin-Yang Kang.

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Park, JB., Choi, BK. & Kang, CY. Effects of absorbent materials on a self-emulsifying drug delivery system for a poorly water soluble drug. Journal of Pharmaceutical Investigation 45, 529–539 (2015). https://doi.org/10.1007/s40005-015-0201-4

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  • DOI: https://doi.org/10.1007/s40005-015-0201-4

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