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Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs): recent advances in drug delivery

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Abstract

Solid lipid-based nanoparticles (SLBNs) were developed as potential alternatives to other conventional drug delivery systems such as polymeric nanoparticles, liposomes, and emulsions. In general, SLBNs are divided into two types: solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs). SLNs are distinguishable from NLCs by the composition of solid particle matrix. SLBNs can be prepared by several methods including high pressure homogenization, solvent emulsification (or diffusion)-evaporation, and microemulsion technologies. Then, SLBNs can be characterized in terms of particle size distribution, surface charge, morphology, and crystallinity. SLBNs are well-tolerated and efficient carrier systems for parenteral, oral, inhalational, ocular, and dermal applications. This review provides an overview of the preparation and characterization technologies for SLBNs and focuses on recent advances in drug delivery using SLBNs.

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  1. College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam, 534-729, Republic of Korea

    Goo Yoon, Jin Woo Park & In-Soo Yoon

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  1. Goo Yoon
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  2. Jin Woo Park
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Correspondence to In-Soo Yoon.

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Goo Yoon and Jin Woo Park contributed equally to this work.

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Yoon, G., Park, J.W. & Yoon, IS. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs): recent advances in drug delivery. Journal of Pharmaceutical Investigation 43, 353–362 (2013). https://doi.org/10.1007/s40005-013-0087-y

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