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Antibody repertoires in infants and adults: effects of T-independent and T-dependent immunizations

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Abstract

Polysaccharide(PS)-encapsulated bacteria such as Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis are among the most prevalent bacterial pathogens of humans. Infections caused by these organisms are both common (otitis media, sinusitis) and severe (meningitis, bacteremia). Antibodies directed against the capsular PS of encapsulated bacteria prevent infection by promoting opsonophagocytic killing. Most bacterial PS, however, are type II T-cell-independent (TI-2) antigens that are poorly immunogenic in young children at highest risk of developing disease. Conjugation of bacterial PS to a protein carrier converts the immune response to a T-cell-dependent (TD) form and significantly improves the immunogenicity of PS, especially in infants. H. influenzae type b (Hib) is a major cause of invasive infection in non-immune children. The medical importance of this pathogen and the availability of both TI-2 and TD Hib PS Vaccine formulations have made the human anti-Hib-PS immune response an excellent model for the study of the biology of these B cell responses.

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References

  1. Adderson EE, Shackelford PG, Quinn A, Carroll WL (1991) Restricted Ig H chain V gene usage in the human antibody response to Haemophilus influenzae type b capsular Polysaccharide. J Immunol 147:1667

    PubMed  CAS  Google Scholar 

  2. Adderson EE, Azmi FH, Wilson PM, Shackelford PG, Carroll WL (1993) The human VH3 gene family is highly Polymorphie. J Immunol 151:800

    PubMed  CAS  Google Scholar 

  3. Adderson EE, Shackelford PG, Quinn A, Wilson PM, Cunningham MW, Insel RA, Carroll WL (1993) Restricted Immunoglobulin VH usage and VDJ combinations in the human response to Haemophilus influenzae type b capsular Polysaccharide. Nucleotide sequences of monospeeifie anti-Haemophilus antibodies and polyspecific antibodies cross-reacting with self antigens. J Clin Invest 91:2734

    Article  PubMed  CAS  Google Scholar 

  4. Adderson EE, Wilson PM, Cunningham MW, Shackelford PG (1998) Haemophilus influenzae type b polysaccharide-protein conjugate Vaccine elicits a more diverse antibody repertoire in infants than in adults. J Immunol 161:4177

    PubMed  CAS  Google Scholar 

  5. Ambrosino DM, Greif W, Thompson C, Siber GR (1990) Kappa and lambda light chain composition of antibody to the capsular Polysaccharide of Haemophilus influenzae type b. J Infect Dis 161:922

    PubMed  CAS  Google Scholar 

  6. Amir J, Scott MG, Nahm MH, Granoff DM (1990) Bactericidal and opsonic activity of IgG1 and IgG2 anticapsular antibodies to Haemophilus influenzae type b. J Infect Dis 162:163

    PubMed  CAS  Google Scholar 

  7. Anderson P (1984) The protective level of serum antibodies to the capsular Polysaccharide of Haemophilus influenzae type b. J Infect Dis 149:1034

    PubMed  CAS  Google Scholar 

  8. Anderson P, Smith DH, Ingram DL, Wilkins J, Wehrle PF, Howie VM (1977) Antibody of polyribophosphate of Haemophilus influenzae type b in infants and children: effect of immunization with poly-ribophosphate. J Infect Dis 136:S57

    Google Scholar 

  9. Barington T, Skettrup M, Juul L, Heilmann C (1993) Noon-epitope-specific suppression of the antibody response to Haemophilus influenzae type b conjugate vaccines by preimmunization with Vaccine components. Infect Immun 61:432

    PubMed  CAS  Google Scholar 

  10. Barington T, Gyhrs A, Kristensen K, Heilmann C (1994) Opposite effects of actively and passively acquired immunity to the carrier on responses of human infants to a Haemophilus influenzae type b conjugate Vaccine. Infect Immun 62:9

    PubMed  CAS  Google Scholar 

  11. Bondada S, Robertson DA, Chelvarajan RL (2000) Accessory cell defect in unresponsiveness of neonates and aged to Polysaccharide vaccines. Vaccine 19:557

    Article  PubMed  CAS  Google Scholar 

  12. Breukels MA, Rijkers GT, Voorhorst-Ogink MM, Zegers BJ (1999) Regulatory T cells in the antibody response to Haemophilus influenzae type b Polysaccharide. Infect Immun 67:789

    PubMed  CAS  Google Scholar 

  13. Butler JC, Breiman RF, Campbell JF, Lipman HB, Broome CV, Facklam RR (1993) Pneumococcal polysaccharide vaccine efficacy. An evaluation of current recommendations. JAMA 270:1826

    Article  PubMed  CAS  Google Scholar 

  14. Chen J, Alt FW (1993) Gene rearrangement and B-cell development. Curr Opin Immunol 5:194

    Article  PubMed  CAS  Google Scholar 

  15. Coulehan JL, Michaels RH, Hallowell C (1984) Epidemiology of H. influenzae type b disease among Navajo Indians. Public Health Rep 99:404

    PubMed  CAS  Google Scholar 

  16. Decker MD, Edwards KM, Bradley R, Palmer P (1992) Comparative trial in infants of four conjugate Haemophilus influenzae type b vaccines. J Pediatr 120:184

    Article  PubMed  CAS  Google Scholar 

  17. Desiderio SV, Yancopoulos GD, Paskind M, Thomas E, Boss MA, Landau N, Alt FW (1984) Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells. Nature 311:752

    Article  PubMed  CAS  Google Scholar 

  18. Einhorn MS, Weinberg GA, Anderson EL, Granoff PD, Granoff DM (1986) Immunogenicity in infants of Haemophilus influenzae type b Polysaccharide in a conjugate Vaccine with Neisseria meningitidis outer membrane protein complex. Lancet 2:299

    Article  PubMed  CAS  Google Scholar 

  19. Eskola J, Kayhty H, Takala AK, Peltola H, Ronnberg PR, Kela E, Pekkanen E, McVerry PH, Makela PH (1990) A randomized, prospective field trial of a conjugate Vaccine in the protection of infants and young children against invasive Haemophilus influenzae type b disease. N Engl J Med 323:1381

    PubMed  CAS  Google Scholar 

  20. Fairhurst RM, Wang CX, Sieling PA, Modlin RL, Braun J (1998) CD1 presents antigens from a gramnegative bacterium, Haemophilus influenzae type B. Infect Immun 66:3523

    PubMed  CAS  Google Scholar 

  21. Farley MM, Stephens DS, Harvey RC, Sikes RK, Wenger JD (1992) Incidence and clinical characteristics of invasive Haemophilus influenzae disease in adults. CDC Meningitis Surveillance Group. J Infect Dis 165:S42

    Google Scholar 

  22. Feeney AJ, Atkinson MJ, Cowan MJ, Escuro G, Lugo G (1996) A defective VκA2 allele in Navajos which may play a role in increased susceptibility to Haemophilus influenzae type b disease. J Clin Invest 97:2277

    Article  PubMed  CAS  Google Scholar 

  23. Feeney AJ, Lugo G, Escuro G (1997) Human cord blood κ repertoire. J Immunol 158:3761

    PubMed  CAS  Google Scholar 

  24. Fothergill LD, Wright J (1933) Influenzal rneningitis: the relation of age incidence to the bactericidal power of blood against the causal organism. J Immunol 273

  25. French DL, Laskov R, Scharft MD (1989) The role of somatic hypermutation in the generation of antibody diversity. Science 244:1152

    Article  PubMed  CAS  Google Scholar 

  26. Granoff DM, Lucas AH (1995) Laboratory correlates of protection against Haemophilus influenzae type b disease. Importance of assessment of antibody avidity and immunologic mernory. Ann NY Acad Sei 754:278

    Article  CAS  Google Scholar 

  27. Granoff DM, Anderson EL, Osterholm MT, Holmes SJ, McHugh JE, Belshe RB, Medley F, Murphy TV (1992) Differences in the immunogenicity of three Haemophilus influenzae type b conjugate vaccines in infants. J Pediatr 121:187

    Article  PubMed  CAS  Google Scholar 

  28. Granoff DM, Boies E, Squires J, Pandey JP, Suarez B, Oldfather J, Rodey GE (1984) Interactive effect of genes associated with Immunoglobulin allotypes and HLA specificities on susceptibility to Haemophilus influenzae disease. J Immunogenet 11:181

    Article  PubMed  CAS  Google Scholar 

  29. Granoff DM, Holmes SJ, Belshe RB, Osterholm MT, McHugh JE, Anderson EL (1994) Effect of carrier protein priming on antibody responses to Haemophilus influenzae type b (HIB) conjugate vaccines in infants. JAMA 272:1116

    Article  PubMed  CAS  Google Scholar 

  30. Hansman D, Hanna J, Morey F (1986) High prevalence of invasive Haemophilus influenzae disease in central Australia. Lancet 2:927

    Article  PubMed  CAS  Google Scholar 

  31. Hardy RR, Carmack CE, Li YS, Hayakawa K (1994) Distinctive developmental origins and specificities of murine CD5+ B cells. Immunol Rev 137:91

    Article  PubMed  CAS  Google Scholar 

  32. Hougs L, Juul L, Ditzel HJ, Heilmann C, Svejgaard A, Barington T (1999) The first dose of a Haemophilus influenzae type b conjugate Vaccine reactivates memory B cells: evidence for extensive clonal selection, intraclonal affinity maturation and multiple isotype swiches to IgA2. J Immunol 162:224

    PubMed  CAS  Google Scholar 

  33. Hougs L, Juul L, Svejgaard A, Barington T (1999) Structural requirements of the major protective antibody to Haemophilus influenzae type b. Infect Immun 67:2503

    PubMed  CAS  Google Scholar 

  34. Hutchins WA, Carlone GM, Westerink MAJ (1999) Elderly immune response to a TI-2 antigen: heavy and light chain use and bactericidal activity to Neisseria meningitidis serogroup C Polysaccharide. J Infect Dis 179:1433

    Article  PubMed  CAS  Google Scholar 

  35. Insel RA, Anderson PW (1986) Oligosaccharide-protein conjugate vaccines induce and prime for oligoclonal IgG antibody responses to the Haemophilus influenzae b capsular Polysaccharide in human infants. J Exp Med 163:262

    Article  PubMed  CAS  Google Scholar 

  36. Insel RA, Kittelberger A, Anderson PW (1985) Isoelectric focusing of human antibody to the Haemophilus influenzae b capsular polysaccharide: restricted and identical spectrotypes in adults. J Immunol 4:2810

    Google Scholar 

  37. Juul L, Hougs L, Andersen V, Garred P, Ryder LP, Svejgaard A, Hogh B, Lamm L, Graugaard B, Barington T (1997) Population studies of the human Vk18 gene polymorphisms in Caucasians, Blacks, and Eskimos. New functional alleles and evidence for evolutionary selection for a more restricted antibody repertoire. Tissue Antigens 49:595

    Article  PubMed  CAS  Google Scholar 

  38. Kawasaki K, Minoshima S, Nakato E, Shibuya K, Shintani A, Asakawa S, Sasaki T, Klobeck HG, Combriato G, Zachau HG, Shimizu N (2001) Evolutionary dynamics of the human immunoglobulin kappa locus and the germline repertoire of the Vkappa genes. Eur J Immunol 31:1017

    Article  PubMed  CAS  Google Scholar 

  39. Kayhty H, Peltola H, Karanko V, Makela PH (1983) Protective level of serum antibodies to the capsular Polysaccharide of Haemophilus influenzae type b. J Infect Dis 147:1100

    PubMed  CAS  Google Scholar 

  40. Kayhty H, Schneerson R, Sutton A (1983) Class-specific antibody response to Haemophilus influenzae type b capsular polysaccharide Vaccine. J Infect Dis 148:767

    PubMed  CAS  Google Scholar 

  41. Kayhty H, Karanko V, Peltola H, Makela PH (1984) Serum antibodies after vaccination with Haemophilus influenzae type b capsular Polysaccharide and responses to reimmunization: no evidence of immunologie tolerance or memory. Pediatrics 74:857

    PubMed  CAS  Google Scholar 

  42. Kayhty H, Makela PH, Eskola J, Saarinen L, Seppala I (1988) Isotype distribution and bactericidal activity of antibodies after immunization with Haemophilus influenzae type b vaccines at 18–24 months of age. J Infect Dis 158:973

    PubMed  CAS  Google Scholar 

  43. Lafaille JJ, DeCloux A, Bonneville M, Takagaki Y, Tonegawa S (1989) Junctional sequences of T cell receptor γδ genes: implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining. Cell 59:859

    Article  PubMed  CAS  Google Scholar 

  44. Le Moli S, Matricardi PM, Quinti I, Stroffolini T, D’Amelio R (1991) Clonotypic analysis of human antibodies specific for Neisseria meningitidis polysaccharides A and C in adults. Clin Exp Immunol 83:460

    PubMed  Google Scholar 

  45. Lieberman JM, Greenberg DP, Wong VK, Partridge S, Chang SJ, Chiu CY, Ward JI (1995) Effect of neonatal immunization with diphtheria and tetanus toxoids on antibody responses to Haemophilus influenzae type b conjugate vaccines. J Pediatr 126:198

    Article  PubMed  CAS  Google Scholar 

  46. Losonsky GA, Santosham M, Sehgal VM (1984) H. influenzae in the White Mountain Apaches: molecular epidemiology of a high risk population. Pediatr Infect Dis J 3:539

    CAS  Google Scholar 

  47. Lucas AH, Azmi FH, Mink CM, Granoff DM (1993) Age-dependent V region expression in the human antibody response to the Haemophilus influenzae type b polysaccharide. J Immunol 150: 2056

    PubMed  CAS  Google Scholar 

  48. Lucas AH, Granoff DM (1990) A major crossreactive idiotype associated with human antibodies to the Haemophilus influenzae b polysaccharide. Expression in relation to age and Immunoglobulin G subclass. J Clin Invest 85:1158

    Article  PubMed  CAS  Google Scholar 

  49. Lucas AH, Granoff DM (1995) Functional differences in idiotypically defined IgG1 anti-polysaccharide antibodies elicited by vaccination with Haemophilus influenzae type B polysaccharide-protein conjugates. J Immunol 154:4195

    PubMed  CAS  Google Scholar 

  50. Lucas AH, Granoff DM, Mandrell RE, Connolly CC, Shan AS, Powers DC (1997) Oligoclonality of serum immunoglobulin G antibody responses to Streptococcus pneumoniae capsular polysaccharide serotypes 6B, 14, and 23F. Infect Immun 65:5103

    PubMed  CAS  Google Scholar 

  51. Lucas AH, Langley RJ, Granoff DM, Nahm MH, Kitamura MY, Scott MG (1991) An idiotypic marker associated with a germ-line encoded kappa light chain variable region that predominates the vaccine-induced human antibody response to the Haemophilus influenzae b Polysaccharide. J Clin Invest 88:1811

    Article  PubMed  CAS  Google Scholar 

  52. Lucas AH, Larrick JW, Reason DC (1994) Variable region sequences of a protective human monoclonal antibody specific for the Haemophilus influenzae type b capsular Polysaccharide. Infect Immun 62:3873

    PubMed  CAS  Google Scholar 

  53. Lucas AH, Moulton KD, Reason DC (1998) Role of kappa II-A2 light chain CDR-3 junctional residues in human antibody binding to the Haemophilus influenzae type b Polysaccharide. J Immunol 161:3776

    PubMed  CAS  Google Scholar 

  54. Lucas AH, Reason DC (1998) Aging and the immune response to the Haemophilus influenzae type b capsular polysaccharide: retention of the dominant idiotype and antibody function in the elderly. Infect Immun 66:1752

    PubMed  CAS  Google Scholar 

  55. Lucas AH, Reason DC (1999) Polysaccharide vaccines as probes of antibody repertoires in man. Immunol Rev 171:89

    Article  PubMed  CAS  Google Scholar 

  56. Matsuda F, Ishii K, Bourvagnet P, Kuma KI, Hayashida H, Miyata T, Honjo T (1998) The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. J Exp Med 188:1973

    Article  Google Scholar 

  57. Murphy TV, Clements JF, Petroni M, Coury S, Setler L (1989) Haemophilus influenzae type b in respiratory secretions. Pediatr Infect Dis J 8:148

    PubMed  CAS  Google Scholar 

  58. Murphy TV, White KE, Pastor P, Gabriel L, Medley F, Granoff DM, Osterholm MT (1993) Declining incidence of Haemophilus influenzae type b disease since introduction of vaccination. JAMA 13:246

    Article  Google Scholar 

  59. Musher DM, Chapman AJ, Gorce A, Jonsson S, Briles D, Bangu RE (1986) Natural and vaccine-related immunity to Streptococcus pneumoniae. J Infect Dis 154:245

    PubMed  CAS  Google Scholar 

  60. Musher DM, Groover JE, Graviss EA, Baugn RE (1996) The lack of association between aging and postvaccination levels of IgG antibody to capsular Polysaccharides of Streptococcus pneumoniae. Clin Infect Dis 22:165

    PubMed  CAS  Google Scholar 

  61. Pecanha LMT, Snapper CM, Finkelman FD, Mond JJ (1991) Dextran-conjugated anti-Ig antibodies as a model for T cell-independent type 2 antigen-mediated Stimulation of Ig secretion in vitro. I. Lymphokine dependence. J Immunol 146:833

    PubMed  CAS  Google Scholar 

  62. Peltola H (2000) Worldwide Haemophilus influenzae type b disease at the beginning of the 21st Century: global analysis of the disease burden 25 years after the use of the polysaccharide vaccine and a decade after the advent of conjugates. Clin Microbiol Rev 13:302

    Article  PubMed  CAS  Google Scholar 

  63. Peltola H, Kayhty H, Virtanen M, Makela PH (1984) Prevention of Haemophilus influenzae type b bacteremic infections with the capsular Polysaccharide Vaccine. N Engl J Med 310:1561

    PubMed  CAS  Google Scholar 

  64. Pinchuk GV, Nottnburg C, Milner ECB (1995) Predominant V-region configurations in the human antibody response to Haemophilus influenzae capsule Polysaccharide. Scand J Immunol 41:324

    Article  PubMed  CAS  Google Scholar 

  65. Reason DC, Wagner TC, Tang VR, Moulton KD, Lucas AFI (1999) Polysaccharide binding potential of the human A2 or A18 kappa light chain homologues. Infect Immun 67:994

    PubMed  CAS  Google Scholar 

  66. Reisen WF, Skvaril F, Braun DG (1976) Natural infection of man with group A Streptococci. Levels, restriction in class, subclass and type, and clonal appearance of Polysaccharide group-specific antibodies. Scand J Immunol 5:383

    Article  Google Scholar 

  67. Rijkers GT, Sanders EAM, Breukels MA, Zegers BJM (1998) Infant B cell responses to polysaccharide determinants. Vaccine 16:2731

    Article  Google Scholar 

  68. Robbins JB, Parke JC Jr, Schneerson R, Whisnant JK (1973) Quantitative measurement of “natural” and immunization-induced Haemophilus influenzae type b capsular Polysaccharide antibodies. Pediatr Res 7:103

    Article  PubMed  CAS  Google Scholar 

  69. Romero-Steiner S, Musher DM, Cetron MS, Pais LB, Groover JE, Fiore AE, Plikaytis BD, Carlone GM (1999) Reduction in functional antibody activity against Streptococcus pneumoniae in vaccinated elderly individuals highly correlates with decreased IgG antibody avidity. Clin Infect Dis 29:289

    Article  Google Scholar 

  70. Rubins JB, Alter M, Loch J, Janoff EN (1999) Determination of antibody responses of elderly adults to all 23 capsular polysaccharides after pneumococcal vaccination. Infect Immun 67:5979

    PubMed  CAS  Google Scholar 

  71. Schable G, Rappold GA, Pargent W, Zachau HG (1993) The Immunoglobulin kappa locus: polymorphism and haplotypes of Caucasoid and non-Caucasoid individuals. Hum Genet 91:261

    Google Scholar 

  72. Schlesinger Y, Granoff DM (1992) Avidity and bactericidal activity of antibody elicited by different Haemophilus influenzae type b conjugate vaccines. JAMA 67:1489

    Article  Google Scholar 

  73. Schneerson R, Robbins JB (1975) Induction of serum Haemophilus influenzae type b capsular antibodies in adult volunteers fed cross-reacting Escherichia coli O75:K100:H5. N Engl J Med 292:1093

    PubMed  CAS  Google Scholar 

  74. Schroeder HW Jr, Wang JY (1990) Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life. Proc Natl Acad Sei USA 87:6146

    Article  CAS  Google Scholar 

  75. Scott MG, Crimmins DL, McCourt DW, Chung G, Schable KF, Theibe R, Quenzel EM, Zachau HG, Nahm MH (1991) Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b Polysaccharide. IV. The less frequently expressed VL are heterogeneous. J Immunol 147:4007

    PubMed  CAS  Google Scholar 

  76. Scott MG, Crimmins DL, McCourt DW, Zocher I, Thiebe R, Zachau HG, Nahm MH (1989) Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b Polysaccharide. III. A single VKII gene and one of several JK genes are joined by an invariant arginine to form the most common L chain V region. J Immunol 143:4110

    PubMed  CAS  Google Scholar 

  77. Scott MG, Tarrand JJ, Crimmins DL, McCourt DW, Siegel NR, Smith CE, Nahm MH (1989) Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b Polysaccharide. II. IgG antibodies contain VH genes from a single VH family and VL genes from at least four VL families. J Immunol 143:293

    PubMed  CAS  Google Scholar 

  78. Shackelford PG (1993) IgG subclasses: importance in pediatric practice. Pediatr Rev 14:291

    Article  PubMed  CAS  Google Scholar 

  79. Shackelford PG, Granoff DM, Nelson SJ, Scott MG, Smith DH, Nahm MH (1987) Subclass distribution of human antibodies to Haemophilus influenzae type b capsular Polysaccharide. J Immunol 138: 587

    PubMed  CAS  Google Scholar 

  80. Shelly MA, H. J, Riley GJ, Graves BT, Pichichero M, Treanor JJ (1997) Comparison of pneumococcal polysaccharide and CRM197-conjugated oligosaccharide vaccines in young and elderly adults. Infect Immun 65:242

    PubMed  CAS  Google Scholar 

  81. Silverman GJ, Lucas AH (1991) Variable region diversity in human circulating antibodies specific for the capsular polysaccharide of Haemophilus influenzae type b. Preferential usage of two types of VH3 heavy chains. J Clin Invest 88:911

    Article  PubMed  CAS  Google Scholar 

  82. Smith DH, Peter G, Ingram DL, Harding AL, Anderson P (1973) Responses of children immunized with the capsular polysaccharide of Haemophilus influenzae type b. Pediatrics 52:637

    PubMed  CAS  Google Scholar 

  83. Snapper CM, Yamaguchi H, Moorman MA, Mond JJ (1994) An in vitro model for T cell-independent induction of humoral immunity. A requirement for NK cells. J Immunol 152:4884

    PubMed  CAS  Google Scholar 

  84. St Geme JW, III Falkovv S (1991) Loss of capsule expression by Haemophilus influenzae type b results in enhanced adherence to and invasion of human cells. Infect Immun 59:1325

    PubMed  Google Scholar 

  85. Stein KE (1992) Thymus-independent and thymus-dependent responses to polysaccharide antigens. J Infect Dis 165:S49

    Google Scholar 

  86. Stephens DS, Farley MM (1992) Pathogenic events during Haemophilus influenzae type b infection of human nasopharyngeal mucosa. J Infect Dis 1992:S109

  87. Tarrand JJ, Scott MG, Takes PA, Nahm MH (1989) Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b Polysaccharide. Demonstration of three types of V vegions and their association with H and L chain isotypes. J Immunol 142:2519

    PubMed  CAS  Google Scholar 

  88. Ward JI, Lum MK, Margolis HS (1982) H. influenzae disease in Alaskan Eskimos: characteristics of a population with an unusual incidence of invasive disease. Lancet 1:1281

    Google Scholar 

  89. Ward JI, Brenneman G, Letson GW, Heyward WL (1990) Limited efficacy of a Haemophilus influenzae type b conjugated vaccine in Alaska Native infants. The Alaska H. influenzae Vaccine study group. N Engl J Med 323:750

    Article  Google Scholar 

  90. Wechsler RJ, Monroe JG (1995) Immature B lymphocytes are deficient in expression of the src-family kinases p59fyn and p55fgrl. J Immunol 154:1919

    PubMed  CAS  Google Scholar 

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  1. Dept. of Infections Diseases, St. Inde’s Childer’s Research Hospital, 332 N. Lauderdale Street, 38105, Memphis, TN, USA

    Elisabeth E. Adderson

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Adderson, E.E. Antibody repertoires in infants and adults: effects of T-independent and T-dependent immunizations. Springer Semin Immunopathol 23, 387–403 (2001). https://doi.org/10.1007/s281-001-8166-x

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