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Analysis of peritoneal galactomannan for the diagnosis of Aspergillus peritonitis

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Abstract

Here, we report a patient developing a postoperative peritoneal infection by Aspergillus fumigatus. While galactomannan serum levels were negative throughout the time course, galactomannan levels in peritoneal fluids yielded high results. Serological testing of peritoneal fluids for fungal antigens might be a useful and easily applicable tool to support diagnosis of intraabdominal aspergillosis, which represents a rare type of invasive fungal infection.

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References

  1. Brown GD, et al. Hidden killers: human fungal infections. Sci Transl Med. 2012;4:165rv13.

    Article  PubMed  Google Scholar 

  2. Brodská H, et al. Significantly higher procalcitonin levels could differentiate Gram-negative sepsis from Gram-positive and fungal sepsis. Clin Exp Med. 2013;13:165–70.

    Article  PubMed  Google Scholar 

  3. Marková M, et al. Substantially elevated C-reactive protein (CRP), together with low levels of procalcitonin (PCT), contributes to diagnosis of fungal infection in immunocompromised patients. Support Care Cancer. 2013;21:2733–42.

    Article  PubMed  Google Scholar 

  4. Lichtenstern C, et al. Relevance of Candida and other mycoses for morbidity and mortality in severe sepsis and septic shock due to peritonitis. Mycoses. 2015;58:399–407.

    Article  PubMed  Google Scholar 

  5. Imola M, et al. Emergency emicolectomy for intestinal primary Aspergillosis in acute myeloid leukemia. G Chir. 2012;33:74–6.

    CAS  PubMed  Google Scholar 

  6. Kazan E, et al. A retrospective series of gut aspergillosis in haematology patients. Clin Microbiol Infect. 2011;17:588–94.

    Article  CAS  PubMed  Google Scholar 

  7. Lehrnbecher T, et al. Primary intestinal aspergillosis after high-dose chemotherapy and autologous stem cell rescue. Pediatr Infect Dis J. 2006;25:465–6.

    Article  PubMed  Google Scholar 

  8. Mohite U, et al. Invasive aspergillosis localised to the colon presenting as toxic megacolon. Eur J Haematol. 2007;78:270–3.

    Article  CAS  PubMed  Google Scholar 

  9. Karaman I, Karaman A, Boduroğlu EC, Erdoğan D, Tanır G. Invasive Aspergillus infection localized to the gastric wall: report of a case. Surg Today. 2012;43:682–4.

    Article  PubMed  Google Scholar 

  10. Pasqualotto AC, Denning DW. Post-operative aspergillosis. Clin Microbiol Infect. 2006;12:1060–76.

    Article  CAS  PubMed  Google Scholar 

  11. Jensen J, et al. Post-surgical invasive aspergillosis: an uncommon and under-appreciated entity. J Infect. 2010;60:162–7.

    Article  PubMed  Google Scholar 

  12. De Pauw B, et al. Revised definitions of invasive fungal disease from the European organization for research and treatment of cancer/invasive fungal infections cooperative group and the national institute of allergy and infectious diseases mycoses study group (EORTC/MSG) consensus group. Clin Infect Dis Off Publ Infect Dis Soc Am. 2008;46:1813–21.

    Article  Google Scholar 

  13. Maertens J, et al. Autopsy-controlled prospective evaluation of serial screening for circulating galactomannan by a sandwich enzyme-linked immunosorbent assay for hematological patients at risk for invasive aspergillosis. J Clin Microbiol. 1999;37:3223–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Ku NS, et al. Diagnostic value of the serum galactomannan assay for invasive aspergillosis: it is less useful in non-haematological patients. Scand J Infect Dis. 2012;44:600–4.

    Article  CAS  PubMed  Google Scholar 

  15. Marr KA, Laverdiere M, Gugel A, Leisenring W. Antifungal therapy decreases sensitivity of the Aspergillus galactomannan enzyme immunoassay. Clin Infect Dis. 2005;40:1762–9.

    Article  CAS  PubMed  Google Scholar 

  16. Bassetti M, et al. A research agenda on the management of intra-abdominal candidiasis: results from a consensus of multinational experts. Intensive Care Med. 2013;39:2092–106.

    Article  PubMed  Google Scholar 

  17. Ates O, et al. Diagnosis of Aspergillus niger peritonitis in a peritoneal dialysis patient by peritoneal galactomannan and β-d-glucan detection. Perit Dial Int. 2013;33:216–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Leelahavanichkul A, et al. (1 → 3)-β-d-glucan and galactomannan for differentiating chemical ‘black particles’ and fungal particles inside peritoneal dialysis tubing. Perit Dial Int J Int Soc Perit Dial. 2015. doi:10.3747/pdi.2014.00235.

    Google Scholar 

  19. Worasilchai N, et al. (1 → 3)-β-d-glucan and galactomannan testing for the diagnosis of fungal peritonitis in peritoneal dialysis patients, a pilot study. Med Mycol. 2015;53:338–46.

    Article  PubMed  Google Scholar 

  20. Bassetti M, et al. How to manage aspergillosis in non-neutropenic intensive care unit patients. Crit Care. 2014;18:458.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Miles R, et al. Predictors and outcomes of fungal peritonitis in peritoneal dialysis patients. Kidney Int. 2009;76:622–8.

    Article  PubMed  Google Scholar 

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Correspondence to Karl Dichtl.

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Dichtl, K., Wagener, J., Tschöp, J. et al. Analysis of peritoneal galactomannan for the diagnosis of Aspergillus peritonitis. Infection 44, 683–686 (2016). https://doi.org/10.1007/s15010-016-0902-2

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  • DOI: https://doi.org/10.1007/s15010-016-0902-2

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