Skip to main content

Advertisement

SpringerLink
Log in

A disseminated Mycoplasma hominis infection in a patient with an underlying defect in humoral immunity

  • Case Report
  • Published:
Infection Aims and scope Submit manuscript

Abstract

Non-urogenital Mycoplasma hominis infections are rare, but may cause life-threatening complications. We describe a case of disseminated M. hominis infection with extensive abscess formation in an immunocompromised patient with iatrogenic hypogammaglobulinemia under rituximab treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. CLSI. Interpretive criteria for identification of bacteria and fungi by DNA target sequencing; Approved Guideline. CLSI document MM18-A. Wayne: Clinical and Laboratory Standards Institute. 2008.

  2. Pailhories H, Rabier V, Eveillard M, Mahaza C, Joly-Guillou M-L, Chennebault J-M, Kempf M, Lemarie C. A case report of Mycoplasma hominis brain abscess identified by MALDI-TOF mass spectrometry. Int J Infect Dis. 2014;29:166–8.

    Article  CAS  PubMed  Google Scholar 

  3. Fenollar F, Gauduchon V, Casalta J-P, Lepidi H, Vandenesch F, Raoult D. Mycoplasma endocarditis: two case reports and a review. Clin Infect Dis. 2004;38:e21–4.

    Article  PubMed  Google Scholar 

  4. Miana AN, Farney AC, Mendleya SR. Mycoplasma hominis septic arthritis in a pediatric renal transplant recipient: case report and review of the literature. Am J Transplant. 2005;5:183–8.

    Article  Google Scholar 

  5. MacKenzie CR, Nischik N, Kram R, Krauspe R, Jäger M, Henrich B. Fatal outcome of a disseminated dual infection with drug-resistant Mycoplasma hominis and Ureaplasma parvum originating from a septic arthritis in an immunocompromised patient. Int J Infect Dis. 2010;14(Suppl 3):e307–9.

    Article  PubMed  Google Scholar 

  6. Wylam ME, Kennedy CC, Hernandez NM, Peters SG, Maleszewski JJ, Cassivi SD, Scott JP. Fatal hyperammonaemia caused by Mycoplasma hominis. Lancet. 2013;382:1956.

    Article  PubMed  Google Scholar 

  7. Meyer RD, Clough W. Extragenital Mycoplasma hominis infections in adults: emphasis on immunosuppression. Clin Infect Dis. 1993;17:S243–9.

    Article  PubMed  Google Scholar 

  8. Irie E, Shirota Y, Suzuki C, Tajima Y, Ishizawa K, Kameoka J, Harigae H, Ishii T. Severe hypogammaglobulinemia persisting for 6 years after treatment with rituximab combined chemotherapy due to arrest of B lymphocyte differentiation together with alteration of T lymphocyte homeostasis. Int J Hematol. 2010;91:501–8.

    Article  CAS  PubMed  Google Scholar 

  9. Gdoura R, Kchaou W, Chiraz Chaari C, Abir Znazen A, Leila Keskes L, Tarek Rebai T, Hammami A. Ureaplasma urealyticum, Ureaplasma parvum, Mycoplasma hominis and Mycoplasma genitalium infections and semen quality of infertile men. BMC Infect Dis. 2007;7:129.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Waites KB, Crabb DM, Duffy LB. Comparative in vitro activities of the investigational fluoroquinolone DC-159a and other antimicrobial agents against human Mycoplasmas and Ureaplasmas. Antimicrob Agents Chemother. 2008;10:3776–8.

    Article  Google Scholar 

  11. Krausse R, Schubert S. In-Vitro activities of tetracyclines, macrolides, fluoroquinolones and clindamycin against Mycoplasma hominis and Ureaplasma ssp. Isolated in Germany over 20 years. Clin Microbiol Infect. 2010;16:1649–55.

    Article  CAS  PubMed  Google Scholar 

  12. Kenny GE, Cartwright FD. Susceptibilities of Mycoplasma hominis, M. pneumoniae, and Ureaplasma urealyticum to GAR-936, dalfopristin, dirithromycin, evernimicin, gatifloxacin, linezolid, moxifloxacin, quinupristin-dalfopristin, and telithromycin compared to their susceptibilities to reference macrolides, tetracyclines, and quinolones. Antimicrob Agents Chemother. 2001;45:2604–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Pereyre S, Tardy F, Renaudin H, Cauvin E, del Prá Netto Machado L, Tricot A, Benoit F, Treilles M, Bébéar C. Identification and subtyping of clinically relevant human and ruminant Mycoplasmas by use of matrix-assisted laser desorption ionization–time of flight mass spectrometry. J Clin Microbiol. 2013;51:3314–23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medical Microbiology, Algemeen Ziekenhuis Sint-Jan Brugge-Oostende AV, Campus Brugge, Brugge, Belgium

    Eric Nulens, Thomas Van Landschoot, Dieter Dekeyzer, Patrick Descheemaecker & Marijke Reynders

  2. Department of Nephrology and Infectious Diseases, Algemeen Ziekenhuis Sint-Jan Brugge-Oostende AV, Campus Brugge, Brugge, Belgium

    Jens Van Praet

  3. Department of Hematology, Algemeen Ziekenhuis Sint-Jan Brugge-Oostende AV, Campus Brugge, Brugge, Belgium

    Dominik Selleslag

Authors
  1. Eric Nulens
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jens Van Praet
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dominik Selleslag
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Thomas Van Landschoot
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Dieter Dekeyzer
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Patrick Descheemaecker
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Marijke Reynders
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Eric Nulens.

Ethics declarations

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nulens, E., Van Praet, J., Selleslag, D. et al. A disseminated Mycoplasma hominis infection in a patient with an underlying defect in humoral immunity. Infection 44, 379–381 (2016). https://doi.org/10.1007/s15010-015-0859-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s15010-015-0859-6

Keywords

Search

Navigation