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FDG-PET/CT findings during immune reconstitution in an HIV-1 patient infected with visceral leishmaniasis

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Abstract

Visceral leishmaniasis can rarely be unmasked by immune reconstitution in human immunodeficiency virus (HIV)-1-infected patients. We report the first case of immune reconstitution associated with leishmaniasis in an HIV patient to be imaged with [18F]fluorodeoxyglucose positron emission tomography (FDG/PET), at both baseline and after therapy.

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References

  1. Müller M, Wandel S, Colebunders R, Attia S, Furrer H, Egger M; IeDEA Southern and Central Africa. Immune reconstitution inflammatory syndrome in patients starting antiretroviral therapy for HIV infection: a systematic review and meta-analysis. Lancet Infect Dis. 2010;10:251–61.

    Article  PubMed  Google Scholar 

  2. Berry A, Abraham B, Dereure J, Pinzani V, Bastien P, Reynes J. Two case reports of symptomatic visceral leishmaniasis in AIDS patients concomitant with immune reconstitution due to antiretroviral therapy. Scand J Infect Dis. 2004;36:225–7.

    Article  PubMed  Google Scholar 

  3. Lawn SD, Wilkinson RJ. Immune reconstitution disease associated with parasitic infections following antiretroviral treatment. Parasite Immunol. 2006;28:625–33.

    PubMed  CAS  Google Scholar 

  4. Castaigne C, Tondeur M, de Wit S, Hildebrand M, Clumeck N, Dusart M. Clinical value of FDG-PET/CT for the diagnosis of human immunodeficiency virus-associated fever of unknown origin: a retrospective study. Nucl Med Commun. 2009;30:41–7.

    Article  PubMed  Google Scholar 

  5. O’Doherty MJ, Barrington SF, Campbell M, Lowe J, Bradbeer CS. PET scanning and the human immunodeficiency virus-positive patient. J Nucl Med. 1997;38:1575–83.

    PubMed  Google Scholar 

  6. Mortensen BK, Nielsen SD, Christensen CB, Helweg-Larsen J. Immune reconstitution syndrome presenting as probable AIDS-related lymphoma: a case report. AIDS Res Ther. 2011;8:34.

    Article  PubMed  Google Scholar 

  7. Casabianca A, Marchetti M, Zallio F, Feyles E, Concialdi E, Ferroglio E, Biglino A. Seronegative visceral leishmaniasis with relapsing and fatal course following rituximab treatment. Infection. 2011;39:375–8.

    Article  PubMed  CAS  Google Scholar 

  8. Donati P, Paolino G, Panetta C, Muscardin L, Cota C, Giuliani M. Visceral leishmaniasis revealed by a squamous cell carcinoma in an HIV-1 infected patient. Infection. 2013;41:575–8

    Article  PubMed  CAS  Google Scholar 

  9. del Giudice P, Mary-Krause M, Pradier C, Grabar S, Dellamonica P, Marty P, Gastaut JA, Costagliola D, Rosenthal E; French Hospital Database on HIV Clinical Epidemiologic Group. Impact of highly active antiretroviral therapy on the incidence of visceral leishmaniasis in a French cohort of patients infected with human immunodeficiency virus. J Infect Dis. 2002;186:1366–70.

    Article  PubMed  Google Scholar 

  10. Albrecht H. Leishmaniosis—new perspectives on an underappreciated opportunistic infection. AIDS. 1998;12:2225–6.

    Article  PubMed  CAS  Google Scholar 

  11. de la Rosa R, Pineda JA, Delgado J, Macías J, Morillas F, Martín-Sánchez J Leal M, Sánchez-Quijano A, Lissen E. Influence of highly active antiretroviral therapy on the outcome of subclinical visceral leishmaniasis in human immunodeficiency virus-infected patients. Clin Infect Dis. 2001;32:633–5.

    Article  PubMed  Google Scholar 

  12. Lupi A, Todeschini G, Zanco P. Diffuse metabolic activation of reticuloendothelium on F-18 FDG PET imaging in a case of visceral leishmania. Clin Nucl Med. 2006;31:34–6.

    Article  PubMed  Google Scholar 

  13. Yapar AF, Reyhan M, Kocer NE, Aydin M, Nursal GN. Diffuse splenic F-18 FDG uptake in visceral leishmaniasis. Clin Nucl Med. 2011;36:1041–3.

    Article  PubMed  Google Scholar 

  14. Sathekge M, Maes A, Kgomo M, Stoltz A, Van de Wiele C. Use of 18F-FDG PET to predict response to first-line tuberculostatics in HIV-associated tuberculosis. J Nucl Med. 2011;52:880–5.

    Article  PubMed  Google Scholar 

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Correspondence to P. G. Kyrtatos or T. Wagner.

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Kyrtatos, P.G., Debard, A., Martin-Blondel, G. et al. FDG-PET/CT findings during immune reconstitution in an HIV-1 patient infected with visceral leishmaniasis. Infection 41, 1017–1019 (2013). https://doi.org/10.1007/s15010-013-0459-2

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  • DOI: https://doi.org/10.1007/s15010-013-0459-2

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