Abstract
Artemisinin and its derivatives are essential components of artemisinin-based combination therapies for treating severe falciparum malaria. In this paper, we describe the occurrence of haemolysis after oral artemether–lumefantrine treatment. To the best of our knowledge, this is the second reported case of a patient affected by severe falciparum malaria with haemolytic anaemia that is likely associated with oral artemether–lumefantrine treatment.
References
Kano S. Artemisinin-based combination therapies and their introduction in Japan. J Infect Chemother. 2010;16:375–82.
World Health Organization. Guidelines for the treatment of malaria. 2nd ed. Geneva: World Health Organization; 2010.
Rolling T, Schmiedel S, Wichmann D, Wittkopf D, Burchard GD, Cramer JP. Post treatment haemolysis in severe imported malaria after intravenous artesunate: case report of three patients with hyperparasitaemia. Malar J. 2012;11:169.
Kreeftmeijer-Vegter AR, van Genderen PJ, Visser LG. Treatment outcome of intravenous artesunate in patients with severe malaria in the Netherlands and Belgium. Malar J. 2012;11:102.
Caramello P, Balbiano R, De Blasi T, Chiriotto M, Deagostini M, Calleri G. Severe malaria, artesunate and haemolysis. J Antimicrob Chemother. 2012;67:2053–4.
Zoller T, Junghanss T, Kapaun A, Gjørup I, Richter J, Hugo-Persson M, Mørch K, Foroutan B, Suttorp N, Yürek S, Flick H. Intravenous artesunate for severe malaria in travelers, Europe. Emerg Infect Dis. 2011;17:771–7.
World Health Organization (2010) Prequalification programme: a United Nations programme managed by WHO. Geneva: World Health Organization. Available at: http://apps.who.int/prequal.
Garratty G. Immune hemolytic anemia associated with drug therapy. Blood Rev. 2010;24:143–5.
Kwaan HC. Infection and anemia. Infect Disord Drug Targets. 2011;11:40–4.
Anaba FC, Ahiante BO, Pepple DJ. In vitro haemolytic effect of sulfadoxine/pyrimethamine and artemether/lumefantrine on malaria parasitized erythrocytes of female patients. Pak J Pharm Sci. 2012;25:851–5.
Yasouka C, Yasuoka A, Yamamoto Y, Genka I, Hatabu T, Kohno S, Oka S, Kano S. A case of falciparum malaria successfully treated with intravenous artesunate. Kansenshogaku Zasshi. 2001;75:822–5.
Yoshizawa S, Hike K, Kimura K, Matsumoto T, Furuya N, Takeda K, Kano S, Yamaguchi K. A case of falciparum malaria successfully treated with intravenous artesunate. Kansenshogaku Zasshi. 2002;76:888–92.
Itoda I, Yasunami T, Kikuki K, Yamaura H, Totsuka K, Yoshinaga K, Teramura M, Mizoguchi H, Hatabu T, Kano S. Severe falciparum malaria with prolonged haemolytic anemia after successful treatment with intravenous artesunate. Kansenshogaku Zasshi. 2002;76:600–3.
Sagara I, Fofana B, Gaudart J, Sidibe B, Togo A, Toure S, Sanogo K, Dembele D, Dicko A, Giorgi R, Doumbo OK, Djimde AA. Repeated artemisinin-based combination therapies in a malaria hyperendemic area of mali: efficacy, safety, and public health impact. Am J Trop Med Hyg. 2012;87:50–6.
Corpolongo A, De Nardo P, Ghirga P, Gentilotti E, Bellagamba R, Tommasi C, Paglia MG, Nicastri E, Narciso P. Haemolytic anaemia in an HIV-infected patient with severe falciparum malaria after treatment with oral artemether-lumefantrine. Malar J. 2012;11:91.
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The authors acknowledge all contributors to this manuscript and Andrea Baker for editing the English.
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De Nardo, P., Oliva, A., Giancola, M.L. et al. Haemolytic anaemia after oral artemether–lumefantrine treatment in a patient affected by severe imported falciparum malaria. Infection 41, 863–865 (2013). https://doi.org/10.1007/s15010-013-0451-x
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DOI: https://doi.org/10.1007/s15010-013-0451-x