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Interferon-Gamma Release Assay in the Ascites: Early Hint for Diagnosis of Abdominal Tuberculosis

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Abstract

We report on a 20-year-old woman with abdominal tuberculosis.Standard microbiological examination of ascites showedno acid-fast bacilli (AFB), and analysis for the Mycobacteriumtuberculosis (MTB)-complex DNA by PCR was negative. However,the interferon-γ release assay (IGRA) of the ascites waspositive after specific stimulation with mycobacterial antigens(ESAT-6/CFP-10/TB7.7[p4]), indicating an infection with MTB.The diagnosis of tuberculosis was later confirmed by histology,MTB culture, and PCR analysis of MTB-complex DNA in tissuesamples taken during laparoscopy. Thus, the IGRA of ascitesmay guide the decision to start active treatment for tuberculosis.

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Authors and Affiliations

  1. Dept. of Internal Medicine, University Hospital Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany

    R. Lorenz

  2. Dept. of General, Visceral and Transplantation Surgery, UniversityHospital Ulm, Ulm, Germany

    P. Würl & G. Cammerer

  3. Institute of Pathology, University of Ulm, Ulm, Germany

    T. Barth & S. Hausladen

  4. Institute of Medical Microbiology and Hygiene, University of Ulm, Ulm, Germany

    S. Stenger

  5. Section of Infectious Diseases and Clinical Immunology, UniversityHospital Ulm, Ulm, Germany

    G. Haerter & P. Kern

Authors
  1. R. Lorenz
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  2. P. Würl
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  3. G. Haerter
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  4. G. Cammerer
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  6. S. Hausladen
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  7. S. Stenger
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  8. P. Kern
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Correspondence to R. Lorenz.

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Lorenz, R., Würl, P., Haerter, G. et al. Interferon-Gamma Release Assay in the Ascites: Early Hint for Diagnosis of Abdominal Tuberculosis. Infection 38, 69–72 (2010). https://doi.org/10.1007/s15010-009-9469-5

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  • DOI: https://doi.org/10.1007/s15010-009-9469-5

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