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Serum Procalcitonin for Discrimination of Blood Contamination from Bloodstream Infection due to Coagulase-Negative Staphylococci

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Abstract

The diagnostic value of serum procalcitonin (PCT) to distinguish blood contamination from bloodstream infection (BSI) due to coagulase-negative staphylococci was evaluated. Patients with BSI had higher PCT concentration than those with blood contamination at day –1, day 0 and day +1 with regard to blood culture collection (p < 0.05), whereas serum C-reactive protein values were significantly higher only on day +1. At a cutoff of 0.1 ng/dl, PCT had a sensitivity of 86% and 100%, and a specificity of 60% and 80% for the diagnosis of BSI on day –1 and 0, respectively. In addition to clinical and microbiological parameters, PCT may help discriminating blood contamination from BSI due coagulase-negative staphylococci.

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Authors and Affiliations

  1. Dept. of Internal Medicine, University Hospital Basel, Petersgraben 4, Basel, 4031, BS, Switzerland

    P. Schuetz & B. Mueller

  2. Dept. of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Petersgraben 4, Basel, 4031, BS, Switzerland

    A. Trampuz

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  1. P. Schuetz
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  2. B. Mueller
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  3. A. Trampuz
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Correspondence to A. Trampuz.

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Schuetz, P., Mueller, B. & Trampuz, A. Serum Procalcitonin for Discrimination of Blood Contamination from Bloodstream Infection due to Coagulase-Negative Staphylococci. Infection 35, 352–355 (2007). https://doi.org/10.1007/s15010-007-7065-0

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  • DOI: https://doi.org/10.1007/s15010-007-7065-0

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