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Lactic Acidosis after Treatment with Linezolid

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Abstract

Linezolid is currently indicated to treat vancomycin-resistant Enterococcus faecium infections, nosocomial pneumonia caused by Staphylococcus aureus or Streptococcus pneumoniae, complicated and uncomplicated skin and skin structure infections, and community-acquired pneumonia. We report a case of linezolid-induced lactic acidosis during treatment of vancomycin-resistant enterococcal bacteremia after mitral valve replacement and permanent pacemaker implantation. We also review the current literature describing other cases of linezolid-associated hyperlactatemia.

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Authors and Affiliations

  1. Dept. of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    M. Wiener & B. C. Fries

  2. Dept. of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    B. C. Fries

  3. Dept. of Pharmacy, Montefiore Medical Center, Bronx, NY, 10467, USA

    Y. Guo

  4. Dept. of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, NY, 10029, USA

    G. Patel

  5. Division of Infectious Diseases, Montefiore Medical Center, 111 East 210th Street, Centennial Building – Room 437, Bronx, NY, 10467, USA

    M. Wiener

Authors
  1. M. Wiener
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  2. Y. Guo
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  3. G. Patel
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  4. B. C. Fries
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Correspondence to M. Wiener.

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Wiener, M., Guo, Y., Patel, G. et al. Lactic Acidosis after Treatment with Linezolid. Infection 35, 278–281 (2007). https://doi.org/10.1007/s15010-007-6302-x

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  • DOI: https://doi.org/10.1007/s15010-007-6302-x

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