Abstract
Background: This study was undertaken to compare the clinical characteristics of adult methicillin-sensitive Staphylococcus aureus (MSSA) meningitis and adult methicillin-resistant S. aureus (MRSA) meningitis.
Patients and Methods: The clinical characteristics and therapeutic outcomes of 19 adult patients with S. aureus meningitis, including eight with MSSA infections and 11 with MRSA infections, were analyzed. A comparison was made between the clinical data of the patients with MSSA infections and those with MRSA infections.
Results: Before the end of 1995, MSSA infection was involved in all the adult patients with S. aureus meningitis but thereafter, MRSA infection was involved in 79% of the cases. The clincial characteristics found in patients with MSSA infection included underlying medical disorders (75%), community-acquired infection (75%) and mortality rate (13%). The clinical characteristics found in patients with MRSA infection included post-neurosurgical states (91%), nosocomial infections (100%), men outnumbering women (8 : 3), hydrocephalus (36%) and mortality rate (56%). Comparitive study between the patient groups (hematogenous and post-neurosurgical) showed that only the mode of acquisition of infection had statistical significance.
Conclusions: This study showed an increase in MRSA infections in adult S. aureus meningitis in recent years. The clinical characteristics of patients with MSSA and MRSA meningitis were different. Community-acquired infection was common in hematogenous S. aureus meningitis, while nosocomial infection was common in post-neurosurgical yS. aureus meningitis. Vancomycin should be considered as one of the drugs of choice for initial therapy of adult bacterial meningitis, especially in post-neurosurgical patients.
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Received: April 29, 2000 · Revision accepted: June 3, 2001
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Chang, W., Lu, C., Wu, J. et al. Staphylococcus aureus Meningitis in Adults: A Clinical Comparison of Infections Caused by Methicillin-Resistant and Methicillin-Sensitive Strains. Infection 29, 245–250 (2001). https://doi.org/10.1007/s15010-001-1092-z
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DOI: https://doi.org/10.1007/s15010-001-1092-z