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Hepatitis C Virus Genotyping versus Serotyping in Egyptian Patients

  • Clincal and Epidemiological Study
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Abstract

Background: The RNA genome of hepatitis C virus (HCV) displays extensive sequence variation. In this study, serotyping and genotyping techniques were applied to assess this variability by comparing the performance of the serotyping assay with a panel of well-characterized HCV strains isolated from chronic active hepatitis (CAH) patients.

Patients and Methods: 60 serum samples from CAH patients were analyzed. All isolates were genotyped by a line probe assay and the results of genotyping and serotyping were evaluated.

Results: The overall sensitivity of the serotyping and genotyping techniques was 81.16% with a concordance of 73.3%. Type 4 was detected in 73.3% of cases and it was highly heterogeneous.

Conclusion: Type 4 HCV is the most prevalent type in Egyptian CAH patients and there is a high concordance between the results of serotyping and genotyping techniques.

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Authors and Affiliations

  1. Virology and Immunology Unit, Cancer Biology Dept., National Cancer Institute, Cairo University Kasr El Aini St., Fom El Khalig, Cairo 11796, Egypt; Phone and Fax: (+20/23) 63-0583, e-mail: egcs@starnet.com.eg, , , , , , EG

    A.-R.N. Zekri

  2. Pathology Dept., National Cancer Institute, Cairo University, Egypt, , , , , , EG

    A.A. Bahnassy

  3. Biochemistry Dept., National Research Center, Egypt, , , , , , EG

    A.S. Ramadan

  4. Clincal Pathology Dept., Menoufyia University, Egypt, , , , , , EG

    M. El-Bassuoni

  5. Egyptian Cancer Society, Egypt, , , , , , EG

    A. Badran

  6. Tropical Medicine Dept., Ain Shams University, Cairo, Egypt, , , , , , EG

    M.A. Madwar

Authors
  1. A.-R.N. Zekri
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  2. A.A. Bahnassy
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  3. A.S. Ramadan
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  4. M. El-Bassuoni
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  5. A. Badran
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  6. M.A. Madwar
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Additional information

Received: January 18, 2000 · Revision accepted: December 3, 2000

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Zekri, AR., Bahnassy, A., Ramadan, A. et al. Hepatitis C Virus Genotyping versus Serotyping in Egyptian Patients. Infection 29, 24–26 (2001). https://doi.org/10.1007/s15010-001-0010-8

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  • DOI: https://doi.org/10.1007/s15010-001-0010-8

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