Literatur
Schwabe U, Paffrath D, Ludwig WD, Klauber J. Arzneiverordnungs-Report 2019
Hotopf M, Hardy R, Lewis G. Discontinuation rates of SSRIs and tricyclic antidepressants: a meta-analysis and investigation of heterogeneity. Brit J Psychiatry 1997; 170: 120-7
Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO et al. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med 2005; 353: 1209-23
Cerovecki A, Musil R, Klimke A, Seemüller F, Haen E, Schennach R et al. Withdrawal symptoms and rebound syndromes associated with switching and discontinuing atypical antipsychotics: Theoretical background and practical recommendations. CNS Drugs 2013; 27: 545-72
Brooks GW. Withdrawal from neuroleptic drugs. Am J Psychiatr. 1959; 115: 931-2
Dilsaver SC, Greden JF. Antidepressant withdrawal phenomena. BPS 1984; 19: 237-56
Hollister LE, Eikenberry DT, Raffel S. Chlorpromazine in nonpsychotic patients with pulmonary tuberculosis. Am Rev Respir Dis 1960; 81: 562-6
Chouinard G, Samaha A-N, Chouinard V-A, Peretti C-S, Kanahara N, Takase M et al. Antipsychotic-induced dopamine supersensitivity psychosis: Pharmacology, criteria, and therapy. Psychother Psychosom 2017; 86: 189-219
Van Leeuwen E, Petrovic M, van Driel ML, De Sutter AI, Vander Stichele R, Declercq T, et al. Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia. Cochrane Dementia and Cognitive Improvement Group, editor. Cochrane Database of Systematic Reviews 2018; 65: 114
Henssler J, Heinz A, Brandt L, Bschor T. Antidepressant withdrawal and rebound Phenomena. Dtsch Arztebl Int 2019; 116: 355-61
Fava GA, Gatti A, Belaise C, Guidi J, Offidani E. Withdrawal symptoms after selective Serotonin reuptake inhibitor discontinuation: A systematic review. Psychother Psychosom 2015; 84: 72-81
Heinz A, Daedelow L, Wackerhagen L, Di Chiara G. Addiction theory matters - why there is no dependence on caffeine or antidepressant medication (in press). Addiction Biology 2019; 1-10
Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). Deutsche Gesellschaft für Psychiatrie und Psychotherapie, Psychosomatik und Nervenheilkunde e. V. (DGPPN) (Hrsg.) S3-Leitlinie Schizophrenie AWMF-Register Nr. 038-009 Leitlinienreport Stand: 15.03.2019
Geffen E, Brugman M, Hulten R, Bouvy ML, Egberts A, Heerdink ER. Patients' concerns about and problems experienced with discontinuation of antidepressants. Int J Pharmacy Practice 2007; 15: 291-3
Lader M. Benzodiazepine withdrawal states. In: Trimble M R (ed.), Benzodiazepines divided. New York: John Wiley; 1983
Falkai P, Wittchen HU. Diagnostisches und statistisches Manual psychischer Störungen: DSM-5. 2015
Rosenbaum JF, Fava M, Hoog SL, Ascroft RC, Krebs WB. Selective serotonin reuptake inhibitor discontinuation syndrome: a randomized clinical trial. BPS 1998; 44: 77-87
Berber MJ. FINISH: remembering the discontinuation syndrome. Flu-like symptoms, insomnia, nausea, imbalance, sensory disturbances, and hyperarousal (anxiety/agitation). J Clin Psychiatry 1998; 59: 255
Benmansour S, Altamirano AV, Jones DJ, Sanchez TA, Gould GG, Pardon M-C et al. Regulation of the norepinephrine transporter by chronic administration of antidepressants. Biological Psychiatry 2004; 55: 313-6
Kittler K, Lau T, Schloss P. Antagonists and substrates differentially regulate serotonin transporter cell surface expression in serotonergic neurons. Eur J Pharmacology 2010; 629: 63-7
Mirza NR, Nielsen EØ, Troelsen KB. Serotonin transporter density and anxiolytic-like effects of antidepressants in mice. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31: 858-66
Benmansour S, Owens WA, Cecchi M, Morilak DA, Frazer A. Serotonin clearance in vivo is altered to a greater extent by antidepressant-induced downregulation of the serotonin transporter than by acute blockade of this transporter. J Neurosci; 22: 6766-72
Klomp A, Hamelink R, Feenstra M, Denys D, Reneman L. Increased response to a 5-HT challenge after discontinuation of chronic serotonin uptake inhibition in the adult and adolescent rat brain. PLoS ONE 2014; 9: e99873-10
Reidenberg MM. Drug discontinuation effects are part of the pharmacology of a drug. J Pharmacol Exp Ther 2011; 339: 324-8
Dilling H, Freyberger HJ. Taschenführer zur ICD-10-Klassifikation psychischer Störungen. Göttingen, Germany: Hogrefe 2013
Samaha AN, Seeman P, Stewart J, Rajabi H, Kapur S. "Breakthrough" dopamine supersensitivity during ongoing antipsychotic treatment leads to treatment failure over time. J Neurosci 2007; 27: 2979-86
Samaha AN, Reckless GE, Seeman P, Diwan M, Nobrega JN, Kapur S. Less is more: Antipsychotic drug effects are greater with transient rather than continuous delivery. Biol Psychiatry 2008; 64: 145-52
Silvestri S, Seeman MV, Negrete JC, Houle S, Shammi CM, Remington GJ et al. Increased dopamine D2 receptor binding after long-term treatment with antipsychotics in humans: a clinical PET study. Psychopharmacology 2000; 152: 174-80
Leucht S, Davis JM. Do antipsychotic drugs lose their efficacy for relapse prevention over time? Br J Psychiatry 2017; 211: 127-9
Leucht S, Tardy M, Komossa K, Heres S, Kissling W, Salanti G et al. Antipsychotic drugs versus placebo for relapse prevention in schizophrenia: a systematic review and meta-analysis. Lancet 2012; 379: 2063-71
Takeuchi H, Kantor N, Sanches M, Fervaha G, Agid O, Remington G. One-year symptom trajectories in patients with stable schizophrenia maintained on antipsychotics versus placebo: meta-analysis. Br J Psychiatry 2017; 211: 137-43
Taylor MJ, Yim S. Is there rebound psychosis on withdrawal of antipsychotic medication in schizophrenia? Schizophrenia Res 2018; 1-2
El-Mallakh RS, Briscoe B. Studies of long-term use of antidepressants: how should the data from them be interpreted? CNS Drugs 2012; 26: 97-109
Lacoursiere RB, Spohn HE, Thompson K. Medical effects of abrupt neuroleptic withdrawal. Comprehensive Psychiatry 1976; 17: 285-94
Tranter R, Healy D. Neuroleptic discontinuation syndromes. J Psychopharmacol 1998; 12: 401-6
Fava GA, Gatti A, Belaise C, Guidi J, Offidani E. Withdrawal symptoms after selective serotonin reuptake inhibitor discontinuation: A systematic review. Psychother Psychosom 2015; 84: 72-81
Chouinard G, Chouinard V-A. New classification of selective serotonin reuptake inhibitor withdrawal. Psychother Psychosom 2015; 84: 63-71
Perahia DG, Kajdasz DK, Desaiah D, Haddad PM. Symptoms following abrupt discontinuation of duloxetine treatment in patients with major depressive disorder. J Affect Disord 2005; 89: 207-12
Baldwin DS, Montgomery SA, Nil R, Lader M. Discontinuation symptoms in depression and anxiety disorders. Int J Neuropsychopharmacol 2005; 10: 73-12
Markowitz JS, DeVane CL, Liston HL, Montgomery SA. An assessment of selective serotonin reuptake inhibitor discontinuation symptoms with citalopram. Int Clin Psychopharmacol 2000; 15: 329-33
Greenberg LM, Roth S. Differential effects of abrupt versus gradual withdrawal of chlorpromazine in hospitalized chronic schizophrenic patients. Am J Psychiatry 1966; 123: 221-6
Emsley R, Nuamah I, Gopal S, Hough D, Fleischhacker WW. Relapse after antipsychotic discontinuation in schizophrenia as a withdrawal phenomenon vs illness recurrence: A post hoc analysis of a randomized placebo-controlled study. J Clin Psychiatry 2018; 79
DGPPN, BÄK, KBV, AWMF. S3-Leitlinie/Nationale VersorgungsLeitlinie Unipolare Depression - Langfassung, 2. Auflage. Version 5; 2017
Horowitz MA, Taylor D. Tapering of SSRI treatment to mitigate withdrawal symptoms. Lancet Psychiatry 2019; 6: 538-46
Keuthen NJ, Cyr P, Ricciardi JA, Minichiello WE, Buttolph ML, Jenike MA. Medication withdrawal symptoms in obsessive-compulsive disorder patients treated with paroxetine. J Clin Psychopharmacol 1994; 14: 206-7
Benazzi F. Fluoxetine for the treatment of SSRI discontinuation syndrome. Int J Neuropsychopharmacol 2008; 11: 27-2
Giakas WJ, Davis JM. Intractable withdrawal from venlafaxine treated with fluoxetine. Psychiatric Annals 1997; 27: 85-92
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Brandt, L., Henssler, J. & Gutwinski, S. Entstehung, Merkmale, Prävention und Behandlung von Absetzphänomenen. InFo Neurologie 22, 26–35 (2020). https://doi.org/10.1007/s15005-020-1293-6
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DOI: https://doi.org/10.1007/s15005-020-1293-6