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Acer okamotoanum improves cognition and memory function in Aβ25–35-induced Alzheimer’s mice model

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Abstract

We studied the effect of ethyl acetate (EA) fraction from Acer okamotoanum on cognitive improvement and protective abilities in amyloid beta (Aβ)25–35 peptide-injected Alzheimer’s disease (AD) mice. EA was oral administration at 100 and 200 mg/kg/day during the 14 days. We studied the protective effect of EA against AD on the basis of behavioral tests including T-maze test, Novel object recognition test, and Morris water maze test. Control group injected with Aβ25–35 showed significant impairments in memory function. But the oral administration of EA (EA 100 and EA 200 groups) improved the cognition and memory function. In addition, EA against Aβ25–35 peptide has been shown to inhibit lipid peroxidation levels and nitric oxide production in tissues. Acetylcholinesterase (AChE) was elevated in the brain by Aβ25–35 peptide, whereas administration of EA (EA 100 and EA 200 groups) significantly decreased AChE level. Our results indicated that EA improves learning and long-term memory against Aβ25–35 peptide–caused deficit through attenuation of oxidative stress.

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Acknowledgments

This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2015R1D1A1A01058868), Republic of Korea.

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Authors and Affiliations

  1. Department of Food Science and Nutrition & Research Institute of Ecology for the Elderly, Pusan National University, Pusan, 46241, Republic of Korea

    Soo Yeon Choi & Eun Ju Cho

  2. Department of Integrative Plant Science, Chung-Ang University, Anseong, 17546, Republic of Korea

    Jaemin Lee, Dong Gu Lee & Sanghyun Lee

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  1. Soo Yeon Choi
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Correspondence to Sanghyun Lee or Eun Ju Cho.

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Choi, S.Y., Lee, J., Lee, D.G. et al. Acer okamotoanum improves cognition and memory function in Aβ25–35-induced Alzheimer’s mice model. Appl Biol Chem 60, 1–9 (2017). https://doi.org/10.1007/s13765-016-0244-x

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