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Giant calcified pseudoplasm of the nerve axis of the temporal lobe: a case report and review of the literature

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Abstract

Calcifying pseudoneoplasms of the neuraxis (CAPNONs) are rare and can occur along the neural axis. The pathogenesis of these masses is still unknown, and they are diagnosed by histopathological analysis. We report the largest CAPNON in the temporal lobe reported to date and a review of the literature on all previously reported CAPNON cases located in the temporal lobe. According to the literature review, prior to 2020, the largest CAPNON in the temporal lobe that had ever been reported measured 30 × 30 × 20 mm (Mohapatra et al.). However, we report a larger temporal lobe CAPNON (45 × 35 × 35 mm) in a female patient admitted to our hospital. In addition, among 22 patients with CAPNONs aged from 6 to 62 years, 45.5% were female and 54.5% were male. A total of 72.8% of patients presented with seizures, 9.1% had pituitary dysfunction and 9.1% did not have symptoms. Of the cases in the patients with seizures, 83.2% were completely surgically resected, 5.6% were partially surgically resected, and one was treated medically; one patient refused treatment. Except for one patient who had multiple lesions, all patients who underwent surgery exhibited improved or the disappearance of symptoms of epilepsy. The patient in whom epilepsy resolved had undergone total resection. CAPNON is a rare benign lesion that occurs throughout the nervous system, and the pathogenesis remains unclear. Although the hardness of these lesions vary, surgery is still the preferred treatment and yields good results, and total resection is recommended for patients with epilepsy in the temporal lobe.

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Abbreviations

CAPNON:

Calcifying pseudoneoplasms of the neuraxis

EMA:

Epithelial membrane antigen

GFAP:

Glial fibrin acid protein

References

  1. Miller EA (1922) Calculi within the brain. Report of a case of intracranial calcification with successful operation and recovery. SurgGynecolObstet 34:786–789

    Google Scholar 

  2. Gauden A, Kavar B, Nair S (2019) Calcifying pseudoneoplasm of the neuraxis: a case report and review of the literature. J ClinNeurosci 70:257–259

    CAS  Google Scholar 

  3. García Duque S, Medina Lopez D, Ortiz de Méndivil A et al (2016) Calcifying pseudoneoplasms of the neuraxis: report on four cases and review of the literature. ClinNeurolNeurosurg 143:116–120

    Google Scholar 

  4. Lyapichev K, Bregy A, Shah A et al (2014) Occipital calcified pseudoneoplasms of the neuraxis (capnon): understanding a rare pathology. BMJ Case Rep. https://doi.org/10.1136/bcr-2014-206855

    Article  PubMed  PubMed Central  Google Scholar 

  5. Aiken A, Akgun H, Tihan T et al (2009) Calcifying pseudoneoplasms of the neuraxis: Ct, mr imaging, and histologic features. AJNR Am J Neuroradiol 30:1256–1260

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Alshareef M, Vargas J, Welsh C et al (2016) Calcifying pseudoneoplasm of the cervicomedullary junction: case report and a literature review. World Neurosurg 85:364.e311-368

    Article  Google Scholar 

  7. Garen P, Powers J, King J et al (1989) Intracranial fibro-osseous lesion. Case report J Neurosurg 70:475–477

    CAS  PubMed  Google Scholar 

  8. Ghaemi J, Wasimi M, Siripurapu R et al (2016) Calcifying pseudoneoplasm of the neuraxis (capnon): an unusual cause of third nerve palsy in a teenager. BJR Case Rep 2:20150494

    PubMed  PubMed Central  Google Scholar 

  9. Nonaka Y, Aliabadi H, Friedman A et al (2012) Calcifying pseudoneoplasms of the skull base presenting with cranial neuropathies: case report and literature review. J NeurolSurg Rep 73:41–47

    Google Scholar 

  10. Shrier D, Melville D, Millet D et al (1999) Fibro-osseous lesions involving the brain: Mri. Neuroradiology 41:18–21

    Article  CAS  PubMed  Google Scholar 

  11. Kerr E, Borys E, Bobinski M et al (2013) Posterior fossa calcifying pseudoneoplasm of the central nervous system. J Neurosurg 118:896–902

    Article  PubMed  Google Scholar 

  12. Mohapatra I, Manish R, Mahadevan A et al (2010) Calcifying pseudoneoplasm (fibro osseous lesion) of neuraxis (capnon): a case report. ClinNeuropathol 29:223–226

    CAS  Google Scholar 

  13. Nussbaum E, Hilton C, Defillo A et al (2018) Extradural petromastoid calcifying pseudoneoplasm of the neuraxis (capnon): case report and literature review. ClinNeurolNeurosurg 166:99–106

    Google Scholar 

  14. Tiberin P, Beller A (1963) Observations on so-called brain stones or cerebral calculi. Neurology 13:464–476

    Article  CAS  PubMed  Google Scholar 

  15. Maruki C, Nakajima K, Shimoji T et al (1984) Brain stone A case report. No Shinkei Geka 12:1441–1445

    CAS  PubMed  Google Scholar 

  16. Hashimoto M, Tanaka T, Ohgami S et al (1986) A case of idiopathic brain stone presenting as psychomotor epilepsy. No Shinkei Geka 14:1457–1461

    CAS  PubMed  Google Scholar 

  17. Qian J, Rubio A, Powers J et al (1999) Fibro-osseous lesions of the central nervous system: report of four cases and literature review. Am J SurgPathol 23:1270–1275

    Article  CAS  Google Scholar 

  18. Tatke M, Singh A, Gupta V (2001) Calcifying pseudoneoplasm of the cns. Br J Neurosurg 15:521–523

    Article  CAS  PubMed  Google Scholar 

  19. Ghosal N, Thakre D, Murthy G et al (2007) Cerebral calculi in the temporal horn of the lateral ventricle: report of an unusual case. Histopathology 50:817–818

    Article  CAS  PubMed  Google Scholar 

  20. Yan X, Marsh W, Scheithauer B (2011) Dysembryoplasticneuroepithelialtumor and calcifying pseudoneoplasms of the neuraxis: a collision of two seizure-associated lesions. ClinNeuropathol 30:197–202

    CAS  Google Scholar 

  21. Abdaljaleel M, Mazumder R, Patel C et al (2017) Multiple calcifying pseudoneoplasms of the neuraxis (mcapnon): distinct entity, capnon variant, or old neurocysticercosis? Neuropathology 37:233–240

    Article  CAS  PubMed  Google Scholar 

  22. Zerehpoosh F, Samadian M, Azhari V et al (2018) A case report of calcifying pseudoneoplasm of the neuraxis: an incidental finding after a car accident. Turk PatolojiDerg 34:265–268

    Google Scholar 

  23. Paolini M, Ho M, Monahan H et al (2018) Supratentorialcapnon associated with who grade ii meningioma: a case report. Neuropathology 38:535–538

    Article  PubMed  Google Scholar 

  24. Tanoue Y, Uda T, Nakajo K et al (2019) Surgically treated intracranial supratentorial calcifying pseudoneoplasms of the neuraxis (capnon) with drug-resistant left temporal lobe epilepsy: a case report and review of the literature. Epilepsy Behav Case Rep 11:107–114

    Article  PubMed  PubMed Central  Google Scholar 

  25. Vallejo F, Chen S, Bano G et al (2020) Calcifying pseudoneoplasm of the neuroaxis presenting with refractory seizures: case report and literature review. J ClinNeurosci 78:439–443

    Google Scholar 

  26. Barber S, Low J, Johns P et al (2018) Calcifying pseudoneoplasm of the neuraxis: a case illustrating natural history over 17 years of radiologic surveillance. World Neurosurg 115:309–319

    Article  PubMed  Google Scholar 

  27. Yang K, Reddy K, Ellenbogen Y et al (2020) Skull base calcifying pseudoneoplasms of the neuraxis: two case reports and a systematic review of the literature. Can J NeurolSci 47:389–397

    Article  Google Scholar 

  28. Lu J, Yang K, Reddy K et al (2020) Incidental multifocal calcifying pseudoneoplasm of the neuraxis: case report and literature review. Br J Neurosurg. https://doi.org/10.1080/02688697.2020.1738342

    Article  PubMed  Google Scholar 

  29. Rodriguez F, Scheithauer B, Fourney D et al (2008) Ependymoma and intraparenchymal calcifying pseudoneoplasm of the neural axis: incidental collision or unique reactive phenomenon? ActaNeuropathol 115:363–366

    Google Scholar 

  30. Higa N, Yokoo H, Hirano H et al (2017) Calcifying pseudoneoplasm of the neuraxis in direct continuity with a low-grade glioma: a case report and review of the literature. Neuropathology 37:446–451

    Article  PubMed  Google Scholar 

  31. Salim A, Wilson P, Cherukuri R et al (2012) An unusual association of calcifying pseudoneoplasm of the neuraxis with interhemisphericlipoma and agenesis of corpus callosum. Pathology 44:657–659

    Article  PubMed  Google Scholar 

  32. McCarthy FE, Frassica JF (2014) Calcifying pseudotumors of the neural axis. In: Pathology of bone and joint disorders: with clinical and radiographic correlation, 2nd edn. Cambridge University Press, Cambridge, p 294

  33. Hubbard M, Qaiser R, Clark H et al (2015) Multiple calcifying pseudoneoplasms of the neuraxis. Neuropathology 35:452–455

    Article  PubMed  Google Scholar 

  34. Rhodes R, Davis R (1978) An unusual fibro-osseous component in intracranial lesions. Hum Pathol 9:309–319

    Article  CAS  PubMed  Google Scholar 

  35. Inukai M, Shibahara I, Hotta M et al (2020) Case of calcifying pseudoneoplasms of the neuraxis coexisting with interhemisphericlipoma and agenesis of the corpus callosum: involvement of infiltrating macrophages. World Neurosurg 134:635-640.e631

    Article  PubMed  Google Scholar 

  36. Lu J, Berthelet F, Bojanowski M (2020) Letter to the editor regarding “case of calcifying pseudoneoplasms of the neuraxis coexisting with interhemisphericlipoma and agenesis of the corpus callosum: Involvement of infiltrating macrophages.” World Neurosurg 139:668–669

    Article  PubMed  Google Scholar 

  37. Lu J, Popovic S, Provias J et al (2020) Collision lesions of calcifying pseudoneoplasm of the neuraxis and rheumatoid nodules: a case report with new pathogenic insights. Int J Surg Pathol. https://doi.org/10.1177/1066896920941939

    Article  PubMed  Google Scholar 

  38. Bertoni F, Unni K, Dahlin D et al (1990) Calcifying pseudoneoplasms of the neural axis. J Neurosurg 72:42–48

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported by the National Natural Science Foundation of China Grant Number 81801186, Science and Technology Department of Sichuan Provence Grant Number 2020YFQ0009 and Outstanding Subject Development 135 Project of West China Hospital, Sichuan University Grant Number ZY2016102.

Funding

This work was supported by the National Natural Science Foundation of China (Grant Number 81801186), Science and Technology Department of Sichuan Provence (Grant Number 2020YFQ0009) and Outstanding Subject Development 135 Project of West China Hospital, Sichuan University (Grant Number ZY2016102).

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Author notes

  1. Yujian Li and Xiang Yang contributed to the work equally and should be listed as co-first authors.

Authors and Affiliations

  1. Department of Neurosurgery, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Wu Hou District, Chengdu, 610041, Sichuan, People’s Republic of China

    Yujian Li, Xiang Yang, Jun Zheng & Hao Li

  2. Department of Pathology, West China Hospital, Sichuan University, Chengdu, People’s Republic of China

    Zuoyu Liang

  3. Department of Intensive Care Unit, Fourth People’s Hospital of Sichuan Province, Chengdu, People’s Republic of China

    Huiqing Zhou

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  1. Yujian Li
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  4. Jun Zheng
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  6. Hao Li
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and data analysis were performed by YL, XY and JZ. The first draft of the manuscript was written by YL, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Hao Li.

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Li, Y., Yang, X., Liang, Z. et al. Giant calcified pseudoplasm of the nerve axis of the temporal lobe: a case report and review of the literature. Acta Neurol Belg 122, 1477–1484 (2022). https://doi.org/10.1007/s13760-021-01641-1

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  • DOI: https://doi.org/10.1007/s13760-021-01641-1

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