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Microwave-assisted synthesis of pyrido-dipyrimidines using magnetically CuFe2O4 nanoparticles as an efficient, reusable, and powerful catalyst in water

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Abstract

An efficient and direct procedure for the synthesis of pyrido[2,3-d:6,5-d′]dipyrimidine derivatives has been described under microwave-assisted conditions. The reaction of 2-thiobarbituric acid with aromatic aldehydes and ammonium acetate catalyzed by CuFe2O4 nanoparticles was resulted in the formation of pyrido[2,3-d:6,5 d′]dipyrimidine derivatives. The corresponding products have been obtained in excellent isolated yields with high purity, in short reaction times and easy workup.

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Acknowledgments

The authors are grateful to University of Kashan for supporting this work by Grant No. 159148/74.

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Authors and Affiliations

  1. Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, 87317, Islamic Republic of Iran

    Hossein Naeimi & Asieh Didar

  2. Young Researchers and Elite Club, Central Branch, Islamic Azad University, Tehran, Islamic Republic of Iran

    Zahra Rashid

Authors
  1. Hossein Naeimi
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  2. Asieh Didar
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  3. Zahra Rashid
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Correspondence to Hossein Naeimi.

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Naeimi, H., Didar, A. & Rashid, Z. Microwave-assisted synthesis of pyrido-dipyrimidines using magnetically CuFe2O4 nanoparticles as an efficient, reusable, and powerful catalyst in water. J IRAN CHEM SOC 14, 377–385 (2017). https://doi.org/10.1007/s13738-016-0986-8

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  • DOI: https://doi.org/10.1007/s13738-016-0986-8

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