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Synthesis of various heterocyclic compounds via multi-component reactions in water

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Abstract

Due to special effects of water such as abundant, environmentally benign, hydrogen bonding in the transition state and high cohesive energy density as well as negative activation volume; the use of water as a green solvent is emphasized in green chemical processes. Heterocyclic compounds play an important role in the treatment of many diseases and also are effective in biological processes. Multi-component reactions are powerful synthetic methods in construction of new organic molecules because in these methods product is formed as one-pot and reduced number of reaction separation steps. For these reasons, the synthesis of heterocyclic systems using a simple multi-component approach in water is investigated greatly in the recent years. In this review, multi-component reactions that have been used for the synthesis of heterocyclic compounds in aqueous media during the last two decades are described.

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    Abbas Rahmati & Neda Pashmforoush

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Rahmati, A., Pashmforoush, N. Synthesis of various heterocyclic compounds via multi-component reactions in water. J IRAN CHEM SOC 12, 993–1036 (2015). https://doi.org/10.1007/s13738-014-0562-z

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