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Ascorbic acid-induced oxalate nephropathy: a case report and discussion of pathologic mechanisms

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Abstract

Oxalate nephropathy is associated with hereditary hyperoxaluria, Crohn disease, and previous gastric or intestinal surgery, especially in the setting of increased oxalate intake or ethylene glycol ingestion. We present a patient whose intake of vitamin C supplements (2 g/day), exacerbated by predisposing factors of prior small bowel obstruction and resection, and benign prostate hyperplasia (BPH), resulted in acute kidney injury due to oxalate nephropathy. We review past reports of vitamin C-induced oxalate nephropathy and discuss the underlying precipitating factors.

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References

  1. Stokes MB. Acute oxalate nephropathy due to ethylene glycol ingestion. Kidney Int. 2006;69:203.

    Article  CAS  PubMed  Google Scholar 

  2. Gurm H, Sheta MA, Nivera N, et al. Vitamin C-induced oxalate nephropathy: a case report. J Community Hosp Intern Med Perspect. 2012. https://doi.org/10.3402/jchimp.v2i2.17718.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Lamarche J, Nair R, Peguero A, et al. Vitamin C-induced oxalate nephropathy. Int J Nephrol. 2011;2011:146927.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Poulin LD, Riopel J, Castonguay V, et al. Acute oxalate nephropathy induced by oral high-dose vitamin C alternative treatment. Clin Kidney J. 2014;7:218.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Cossey LN, Rahim F, Larsen CP. Oxalate nephropathy and intravenous vitamin C. Am J Kidney Dis. 2013;61:1032–5.

    Article  PubMed  Google Scholar 

  6. Wong K, Thomson C, Bailey RR, et al. Acute oxalate nephropathy after a massive intravenous dose of vitamin C. Aust N Z J Med. 1994;24:410–1.

    Article  CAS  PubMed  Google Scholar 

  7. Duffey BG, Alanee S, Pedro RN, et al. Hyperoxaluria is a long-term consequence of Roux-en-Y Gastric bypass: a 2-year prospective longitudinal study. J Am Coll Surg. 2010;211:8–15.

    Article  PubMed  Google Scholar 

  8. Chaudhari D, Crisostomo C, Ganote C, et al. Acute oxalate nephropathy associated with orlistat: a case report with a review of the literature. Case Rep Nephrol. 2013; 2013:124604.

    PubMed  PubMed Central  Google Scholar 

  9. Hellman L, Burns JJ. Metabolism of l-ascorbic acid-1-C14 in man. J Biol Chem. 1958;230:923–30.

    CAS  PubMed  Google Scholar 

  10. Levine M, Conry-Cantilena C, Wang Y, et al. Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci USA. 1996;93:3704–9.

    Article  CAS  PubMed  Google Scholar 

  11. Knight J, Madduma-Liyanage K, Mobley JA, et al. Ascorbic acid intake and oxalate synthesis. Urolithiasis. 2016;44:289–97.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Verkoelen CF, Verhulst A. Proposed mechanisms in renal tubular crystal retention. Kidney Int. 2007;72:13–8.

    Article  CAS  PubMed  Google Scholar 

  13. Lawton JM, Conway LT, Crosson JT, et al. Acute oxalate nephropathy after massive ascorbic acid administration. Arch Intern Med. 1985;145:950–1.

    Article  CAS  PubMed  Google Scholar 

  14. McHugh GJ, Graber ML, Freebairn RC. Fatal vitamin C-associated acute renal failure. Anaesth Intensive Care. 2008;36:585–8.

    Article  CAS  Google Scholar 

  15. Mousson C, Justrabo E, Rifle G, et al. Piridoxilate-induced oxalate nephropathy can lead to end-stage renal failure. Nephron. 1993;63:104–6.

    Article  CAS  PubMed  Google Scholar 

  16. Rathi S, Kern W, Lau K. Vitamin C-induced hyperoxaluria causing reversible tubulointerstitial nephritis and chronic renal failure: a case report. J Med Case Rep. 2007;1:155.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Nasr SH, Kashtanova Y, Levchuk V, et al. Secondary oxalosis due to excess vitamin C intake. Kidney Int. 2006;70:1672.

    Article  CAS  PubMed  Google Scholar 

  18. Alkhunaizi AM, Chan L. Secondary oxalosis: a cause of delayed recovery of renal function in the setting of acute renal failure. J Am Soc Nephrol. 1996;7:2320–6.

    CAS  PubMed  Google Scholar 

  19. Worcester EM. Stones from bowel disease. Endocrinol Metab Clin N Am. 2002;31(4):979–99.

    Article  CAS  Google Scholar 

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Acknowledgements

The authors are grateful to Bhuvaneswari Krishnan MD for pathology interpretation and Divya Janardhanan MD and Saed Shawar MD for their assistance in the medical care of this patient.

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Authors and Affiliations

  1. School of Medicine, Baylor College of Medicine, Houston, TX, USA

    Weijie Violet Lin

  2. Department of Medicine, Baylor College of Medicine, 7200 Cambridge Street, 10th Floor, Houston, TX, USA

    Christie Gloria Turin, David Walter McCormick, Christopher Haas & Gregory Constantine

Authors
  1. Weijie Violet Lin
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  2. Christie Gloria Turin
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  3. David Walter McCormick
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  4. Christopher Haas
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  5. Gregory Constantine
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Corresponding author

Correspondence to Christie Gloria Turin.

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The authors have declared that no conflicts of interest exists.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Lin, W.V., Turin, C.G., McCormick, D.W. et al. Ascorbic acid-induced oxalate nephropathy: a case report and discussion of pathologic mechanisms. CEN Case Rep 8, 67–70 (2019). https://doi.org/10.1007/s13730-018-0366-6

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  • DOI: https://doi.org/10.1007/s13730-018-0366-6

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