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Pauci-immune crescentic glomerulonephritis associated with use of trimethoprim–sulfamethoxazole

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Abstract

Drug-induced pauci-immune crescentic glomerulonephritis has been described with several agents, including propylthiouracil, minocycline, d-penicillamine, and hydralazine. We present the case of a 60-year-old man who presented with rapidly progressive glomerulonephritis in the setting of recent use of trimethoprim–sulfamethoxazole complicated by the development of the Stevens–Johnson syndrome, and was found to have biopsy-proven pauci-immune crescentic glomerulonephritis and undetectable anti-neutrophilic cytoplasmic antibodies. We review the existing literature on the potential association between sulfonamides and hypersensitivity polyangiitis.

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Authors and Affiliations

  1. Division of Nephrology, Department of Medicine, St. Elizabeth’s Medical Center, 736 Cambridge Street, Boston, MA, 02135, USA

    Shruti S. Hegde & Bertrand L. Jaber

  2. Department of Medicine, Tufts University School of Medicine, Boston, MA, USA

    Shruti S. Hegde & Bertrand L. Jaber

  3. Department of Pathology, Brigham and Women’s Hospital, Boston, MA, USA

    Vanesa Bijol

  4. Harvard Medical School, Boston, MA, USA

    Vanesa Bijol

Authors
  1. Shruti S. Hegde
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  2. Vanesa Bijol
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  3. Bertrand L. Jaber
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Corresponding author

Correspondence to Bertrand L. Jaber.

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All the authors have declared no competing interest.

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Hegde, S.S., Bijol, V. & Jaber, B.L. Pauci-immune crescentic glomerulonephritis associated with use of trimethoprim–sulfamethoxazole. CEN Case Rep 5, 188–191 (2016). https://doi.org/10.1007/s13730-016-0222-5

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  • DOI: https://doi.org/10.1007/s13730-016-0222-5

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