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Analysis of cortisol mechanism to predict common genes between PCOS and its co-morbidities

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Abstract

Polycystic ovary syndrome (PCOS) is a multifactorial endocrine disorder and one of the main causes of PCOS is hormonal imbalance due to lifestyle changes. Estrogen, progesterone, testosterone, cortisol and melatonin are the major hormones that regulate the menstrual cycle and other endocrine disorders in women. The hormone cortisol, in particular, can lead to many comorbid conditions related to PCOS. In this proposed work, PubMed articles were mined using R program to retrieve target genes for PCOS. The NCBI Gene/Genome database was used to download PCOS genes, and genes related to cortisol and major comorbid diseases. Then, commonly intersecting genes among PCOS–Cortisol–Comorbids were identified. From the obtained results, the top seven genes were considered as Hub–Bottleneck genes based on the Degree and Betweenness values of the 26 intersecting (merged) genes. Functional annotation and pathway analysis were performed to examine significant pathways of Hub–Bottleneck genes.

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Data availability

All data were derived from analysis performed by the authors.

Abbreviations

LH:

Luteinizing hormone

HGNC:

HUGO Gene Nomenclature Committee

STRING:

Search tool for the retrieval of interacting genes

PPI:

Protein–protein interaction

MCODE:

Molecular complex detection

MCC:

Maximum clique centrality

GO:

Gene ontology

BP:

Biological processes

CC:

Cellular components

MF:

Molecular functions

KEGG:

Kyoto Encyclopedia of Gene and Genomes

DAVID:

Database for annotation, visualization and integrated discovery

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Authors and Affiliations

  1. Anthropology and Health Informatics Lab, Department of Bioinformatics, Bharathiar University, Coimbatore, Tamil Nadu, India

    V. Vidhya Rajalakshmi & Jayaprakash Chinnappan

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  1. V. Vidhya Rajalakshmi
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  2. Jayaprakash Chinnappan
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Contributions

Conceptualization: VVR and JC; data curation: JC and VVR; formal analysis: JC and VVR; methodology: VVR and JC; project administration and supervision: JC; validation: JC; writing–original draft: VVR and JC; writing—review and editing: VVR and JC.

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Correspondence to Jayaprakash Chinnappan.

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Rajalakshmi, V.V., Chinnappan, J. Analysis of cortisol mechanism to predict common genes between PCOS and its co-morbidities. Netw Model Anal Health Inform Bioinforma 12, 36 (2023). https://doi.org/10.1007/s13721-023-00429-y

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