Skip to main content

Advertisement

Log in

Stasis Dermatitis: Differentiation from Other Common Causes of Lower Leg Inflammation and Management Strategies

  • Dermatology and Wound Care (C Sayed and D Culton, Section Editors)
  • Published:
Current Geriatrics Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Stasis dermatitis is an inflammatory dermatosis of the lower extremities that most commonly occurs in elderly patients with underlying chronic venous insufficiency. In this article, we review the pathogenesis, clinical presentation, diagnostic approach, differential diagnosis, and management strategies of stasis dermatitis.

Recent Findings

Stasis dermatitis can be confused with a variety of cutaneous disorders, including cellulitis, allergic contact dermatitis, pigmented purpuric dermatoses, and lymphedema; therefore, dermatology consultation of patients with lower extremity rash can help improve outcomes and decrease costs. Treatment of stasis dermatitis focuses on correction of the underlying venous insufficiency with compression or minimally invasive venous procedures and management of symptoms and skin changes with emollients and topical steroids.

Summary

Stasis dermatitis is an important disease with which clinicians should be familiar. Prompt recognition and treatment of stasis dermatitis can be important in the prevention of complications, such as venous ulcerations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. Stasis dermatitis | American Academy of Dermatology [Internet]. [cited 2018 May 15]. Available from: https://www.aad.org/public/diseases/eczema/stasis-dermatitis.

  2. Chadachan V, Dean SM, Eberhardt RT. Cutaneous changes in peripheral arterial vascular disease. In: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K, editors. Fitzpatrick’s dermatology in general medicine [Internet]. 8th ed. New York: The McGraw-Hill Companies; 2012. [cited 2018 May 15]. Available from: accessmedicine.mhmedical.com/content.aspx?aid=56080898.

    Google Scholar 

  3. • Sundaresan S, Migden MR, Silapunt S. Stasis dermatitis: pathophysiology, evaluation, and management. Am J Clin Dermatol. 2017;18(3):383–90. This review article provided a great overview of stasis dermatitis and touched upon the prevalence and economic impact, pathogenesis, clinical features, and management options.

    Article  Google Scholar 

  4. McGuckin M, Waterman R, Brooks J, Cherry G, Porten L, Hurley S, et al. Validation of venous leg ulcer guidelines in the United States and United Kingdom. Am J Surg. 2002;183(2):132–7.

    Article  Google Scholar 

  5. Bergan JJ, Schmid-Schönbein GW, Smith PDC, Nicolaides AN, Boisseau MR, Eklof B. Chronic venous disease. N Engl J Med. 2006;355(5):488–98.

    Article  CAS  Google Scholar 

  6. Herouy Y, Mellios P, Bandemir E, Dichmann S, Nockowski P, Schöpf E, et al. Inflammation in stasis dermatitis upregulates MMP-1, MMP-2 and MMP-13 expression. J Dermatol Sci. 2001;25(3):198–205.

    Article  CAS  Google Scholar 

  7. Wenk J, Foitzik A, Achterberg V, Sabiwalsky A, Dissemond J, Meewes C, et al. Selective pick-up of increased iron by deferoxamine-coupled cellulose abrogates the iron-driven induction of matrix-degrading metalloproteinase 1 and lipid peroxidation in human dermal fibroblasts in vitro: a new dressing concept. J Invest Dermatol. 2001;116(6):833–9.

    Article  CAS  Google Scholar 

  8. Gosnell AL, Nedorost ST. Stasis dermatitis as a complication of amlodipine therapy. J Drugs Dermatol. 2009;8(2):135–7.

    PubMed  Google Scholar 

  9. Beebe-Dimmer JL, Pfeifer JR, Engle JS, Schottenfeld D. The epidemiology of chronic venous insufficiency and varicose veins. Ann Epidemiol. 2005;15(3):175–84.

    Article  Google Scholar 

  10. Fiebig A, Krusche P, Wolf A, Krawczak M, Timm B, Nikolaus S, et al. Heritability of chronic venous disease. Hum Genet. 2010;127(6):669–74.

    Article  Google Scholar 

  11. Ruckley CV, Evans CJ, Allan PL, Lee AJ, Fowkes FGR. Chronic venous insufficiency: clinical and duplex correlations. The Edinburgh Vein Study of venous disorders in the general population. J Vasc Surg. 2002;36(3):520–5.

    Article  Google Scholar 

  12. Hogan DJ. Widespread dermatitis after topical treatment of chronic leg ulcers and stasis dermatitis. CMAJ Can Med Assoc J. 1988;138(4):336–8.

    CAS  Google Scholar 

  13. Hirschmann JV, Raugi GJ. Lower limb cellulitis and its mimics: part II. Conditions that simulate lower limb cellulitis. J Am Acad Dermatol. 2012;67(2):177.e1–9. quiz 185–6

    Article  Google Scholar 

  14. Zygmunt JA. Duplex ultrasound for chronic venous insufficiency. J Invasive Cardiol. 2014;26(11):E149–55.

    PubMed  Google Scholar 

  15. Hepburn M, Dooley DP, Ellis MW. Alternative diagnoses that often mimic cellulitis. Am Fam Physician. 2003;67(12):2471.

    PubMed  Google Scholar 

  16. Oh C, Pang S, Chlebicki M, Ho Z, Thirumoorthy T. Cellulitis: making the right diagnosis and its management: a Singapore experience. Hong Kong Journal of Dermatology and Venerology. 2012;20(1):13–19.

  17. Keller EC, Tomecki KJ, Chadi AM. Distinguishing cellulitis from its mimics. Cleve Clin J Med. 2012;79(8):547–52.

    Article  Google Scholar 

  18. Strazzula L, Cotliar J, Fox LP, Hughey L, Shinkai K, Gee SN, et al. Inpatient dermatology consultation aids diagnosis of cellulitis among hospitalized patients: a multi-institutional analysis. J Am Acad Dermatol. 2015;73(1):70–5.

    Article  Google Scholar 

  19. • Milani-Nejad N, Zhang M, Kaffenberger BH. Association of dermatology consultations with patient care outcomes in hospitalized patients with inflammatory skin diseases. JAMA Dermatol. 2017;153(6):523–8. This article discussed the importance of early identification and management of lower extremity inflammatory skin diseases which can improve outcomes among hospitalized patients.

    Article  Google Scholar 

  20. Ko LN, Garza-Mayers AC, St John J, Strazzula L, Vedak P, Shah R, et al. Effect of dermatology consultation on outcomes for patients with presumed cellulitis: a randomized clinical trial. JAMA Dermatol. 2018;154(5):529–36.

    Article  Google Scholar 

  21. Contact dermatitis - Symptoms and causes - Mayo Clinic [Internet]. [cited 2018 May 18]. Available from: https://www.mayoclinic.org/diseases-conditions/contact-dermatitis/symptoms-causes/syc-20352742.

  22. Landeck L, Uter W, John SM. Patch test characteristics of patients referred for suspected contact allergy of the feet--retrospective 10-year cross-sectional study of the IVDK data. Contact Dermatitis. 2012;66(5):271–8.

    Article  Google Scholar 

  23. Opie J, Lee A, Frowen K, Fewings J, Nixon R. Foot dermatitis caused by the textile dye Basic Red 46 in acrylic blend socks. Contact Dermatitis. 2003;49(6):297–303.

    Article  CAS  Google Scholar 

  24. Bolognia J, Jorizzo J, Schaffer J. Dermatology. 3rd ed; 2012.

    Google Scholar 

  25. Id reaction (autoeczematization): background, pathophysiology, epidemiology. 2018 Mar 23 [cited 2018 May 16]; Available from: https://emedicine.medscape.com/article/1049760-overview#a6.

  26. Plachouri K-M, Florou V, Georgiou S. Therapeutic strategies for pigmented purpuric dermatoses: a systematic literature review. J Dermatol Treat. 2018;0(0):1–5.

  27. • Ratchford EV, Evans NS. Approach to Lower Extremity Edema. Curr Treat Options Cardiovasc Med. 2017;19(3):16. This article provided a great overview of lower extremity edema, which is in the differential diagnosis for stasis dermatitis, helping to differentiate between the two.

    Article  Google Scholar 

  28. Alavi A, Sibbald RG, Phillips TJ, Miller OF, Margolis DJ, Marston W, et al. What’s new: management of venous leg ulcers: approach to venous leg ulcers. J Am Acad Dermatol. 2016;74(4):627–40. quiz 641–2

    Article  Google Scholar 

  29. Neumann HA. Compression therapy with medical elastic stockings for venous diseases. Dermatol Surg. 1998;24(7):765–70.

    Article  CAS  Google Scholar 

  30. Carroll C, Hummel S, Leaviss J, Ren S, Stevens JW, Cantrell A, et al. Systematic review, network meta-analysis and exploratory cost-effectiveness model of randomized trials of minimally invasive techniques versus surgery for varicose veins. Br J Surg. 2014;101(9):1040–52.

    Article  CAS  Google Scholar 

  31. Aziz Z, Tang WL, Chong NJ, Tho LY. A systematic review of the efficacy and tolerability of hydroxyethylrutosides for improvement of the signs and symptoms of chronic venous insufficiency. J Clin Pharm Ther. 2015;40(2):177–85.

    Article  CAS  Google Scholar 

  32. Barrett JM, Allen B, Ockelford A, Goldman MP. Microfoam ultrasound-guided sclerotherapy treatment for varicose veins in a subgroup with diameters at the junction of 10 mm or greater compared with a subgroup of less than 10 mm. Dermatol Surg. 2004;30(11):1386–90.

    PubMed  Google Scholar 

  33. Almeida JI, Raines JK. Ambulatory phlebectomy in the office. Perspect Vasc Surg Endovasc Ther. 2008;20(4):348–55.

    Article  Google Scholar 

  34. Klassen W. Office management of stasis ulcer and stasis dermatitis. Can Fam Physician. 1983;29:279–83.

  35. Luz BSR, Araujo CS, Atzingen DANCV, Mendonça AR d A, Mesquita Filho M, de Medeiros ML. Evaluating the effectiveness of the customized Unna boot when treating patients with venous ulcers. An Bras Dermatol. 2013;88(1):41–9.

    Article  Google Scholar 

  36. Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane Database Syst Rev. 2006;1:CD003230.

    Google Scholar 

  37. Maroo N, Choudhury S, Sen S, Chatterjee S. Oral doxycycline with topical tacrolimus for treatment of stasis dermatitis due to chronic venous insufficiency: a pilot study. Indian J Pharmacol. 2012;44(1):111–3.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rachel Blasiak.

Ethics declarations

Conflict of Interest

Alexandra Rzepecki and Rachel Blasiak declare no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

This article is part of the Topical Collection on Dermatology and Wound Care

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rzepecki, A.K., Blasiak, R. Stasis Dermatitis: Differentiation from Other Common Causes of Lower Leg Inflammation and Management Strategies. Curr Geri Rep 7, 222–227 (2018). https://doi.org/10.1007/s13670-018-0257-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13670-018-0257-x

Keywords

Navigation