Abstract
Abietane diterpenes and miltirone series have shown important activities and for medical purposes in order to achieve the total synthesis of 1-oxomiltrone 1 and miltirone 4, a versatile intermediate 6 was found. The compound 6 could be used as a precursor A-B-C rings with different oxidative degrees in selected abietane diterpenes when synthesized through high yield Suzuki reaction and subsequent cyclization, and total synthesis of 1-oxomiltirone (1) has been achieved.
![](http://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs13659-013-0034-7/MediaObjects/13659_2013_34_Article_Fig1_HTML.gif)
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Huang, W. G.; Jiang, Y. Y.; Li, Q.; Li, J.; Li, J. Y.; Lu, W.; Cai, J. C. Tetrahedron2005, 61, 1863–1870
Sairafianpour, M.; Christensen, J.; Stærk, D.; Budnik, B. A.; Kharazmi, A. J. Nat. Prod.2001, 64, 1398–1403.
Kobayashi, K.; Nishino, C. Agric. Biol. Chem.1986, 50, 2405–2407.
Ghosal, M.; Karpha, K.; Manuka, T. K.; Mukherjee, D. Indian J. Chem. B Org.1992, 31, 524–525
Gupta, P. D.; Pal, A.; Mukherjee, D. Indian J. Chem. B Org.2001, 40, 1033–1035.
Huang, W. G.; Li, Y. F.; Lu, W.; Aisa, H. A. Chem. Nat. Compd.2006, 42, 665–667.
Majetich, G.; Liu, S.; Fang, J.; Siesel, D.; Zhang, Y. J. Org. Chem.1997, 62, 6928–6951.
Ghosal, M.; Sukanta Bhattacharyya, S.; Mukherjee, D. Tetrahedron Lett.1989, 30, 3469–3470.
Yadav, J. S.; Kondaji, G.; Shiva Ram Reddy, M.; Srihari, P. Tetrahedron Lett.2008, 49, 3810–3813.
Ruel, F. S.; Braun, M. P.; Johnson, C. R. Org. Synth.2004, Coll. Vol. 10, 467–470.
Sairafianpour, M.; Christensen, J.; Stærk, D.; Budnik, A. B.; Kharazmi, A.; Bagherzadeh, K.; Jaroszewski, W. J. J. Nat. Prod.2001, 64, 1398–1401.
Author information
Authors and Affiliations
Corresponding author
Additional information
This article is published with open access at Springerlink.com
Electronic supplementary material
Rights and permissions
Open Access This article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
About this article
Cite this article
Li, CM., Geng, HC., Li, MM. et al. Total synthesis of 1-oxomiltirone via Suzuki coupling. Nat. Prod. Bioprospect. 3, 117–120 (2013). https://doi.org/10.1007/s13659-013-0034-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13659-013-0034-7