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β(1-3)-D-glucan affects adipogenesis, wound healing and inflammation

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Abstract

Numerous types of β(1-3)-D-glucans have been isolated from almost every species of yeast, grain, and fungi. These products have been extensively studied for their immunological and pharmacological effects. In this paper we evaluated the possibility whether individual β(1-3)-D-glucans will have an activity in less studied areas such as adipogenesis and inflammation. Our results showed that of the tested β(1-3)-D-glucans, yeast-derived insoluble Glucan #300, strongly inhibited adipogenic differentiation, supported wound healing and significantly lowered skin irritation. The remaining β(1-3)-D-glucans were significantly less active. Taken together, our study showed that with respect to natural β(1-3)-D-glucans, there is a clear yes-or-no effect suggesting that highly purified and highly active β(1-3)-D-glucans will have pleiotropic biological impact, whereas poorly isolated and/or less active β(1-3)-D-glucans will have only mediocre properties.

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References

  • Bauerova K, Paulovicova E, Mihalova D, Svik K, Ponist S (2009) Study of new ways of supplementary and combinatory therapy of rheumatoid arthritis with immunomodulators, Glucomannan and Immunoglukan in adjuvant arthritis. Toxicol Industry Health 25:329–335

    Article  CAS  Google Scholar 

  • Beck EJ, Tapsell LC, Batterham MJ, Tosh SM, Huang XF (2009) Increases in peptide Y-Y levels following oat beta-glucan ingestion are dose-dependent in overweight adults. Nutrition Res 29:705–709

    Article  CAS  Google Scholar 

  • Browder W, Williams D, Lucore P, Pretus H, Jones E, McNamee R (1988) Effect of enhanced macrophage function on early wound healing. Surgery 104:224–230

    PubMed  CAS  Google Scholar 

  • Buth H, Wolters B, Hartwig B, Meier-Bornheim R, Veith H, Hansen M, Sommerhoff CP, Schaschke N, Machleidt W, Fusenig NE, Boukamp P, Brix K (2004) HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration. Eur J Cell Biol 83:781–795

    Article  PubMed  Google Scholar 

  • DiLuzio NR, Pisano JC, Saba TM (1970) Evaluation of the mechanism of glucan-induced stimulation of the reticuloendothelial system. J Reticulo-endothel Soc 7:731–42

    CAS  Google Scholar 

  • Di Renzo L, Yefenof E, Klein E (1991) The function of human NK cells is enhanced by beta-glucan, a ligand of CR3 (CD11b/CD18). Eur J Immunol 21:1755–1758

    Article  PubMed  Google Scholar 

  • Fischer-Posovszky P, Wabitsch M, Ochsberg Z (2007) Endocrinology of adipose tissue: an update. Horm Metab Res 39:314–321

    Article  PubMed  CAS  Google Scholar 

  • Hirota K, Morikawa K, Hanada H, Nonaka M, Nakajima Y, Kobayashi M, Nakajima R (2010) Effect of genistein and daidzein on the proliferation and differentiation of human preadipocyte cell line. J Agri Food Chem 58:5821–5827

    Article  CAS  Google Scholar 

  • Kim HD, Cho HR, Mopon SB, Shin HD, Yang KJ, Park BR, Jang HJ, Kim LS, Lee HS, Ku SK (2007) Effects of β-glucan from Aureobasidium pullulans on acute inflammation in mice. Arch Pharm Res 30:323–328

    Article  PubMed  Google Scholar 

  • Kirmaz C, Bayrak P, Yilmaz O, Yuksel H (2005) Effect of glucan treatment on the Th1/Th2 balance in patients with allergic rhinitis: a double-blind placebo-controlled study. Eur Cytokine Netw 16:128–134

    PubMed  CAS  Google Scholar 

  • Kong CS, Kim JA, Eo TK, Kim SK (2010) Phoshorylated glucosamine inhibits adipogenesis in 3T3-L1 adipocytes. J Nutr Biochem 21:438–443

    Article  PubMed  CAS  Google Scholar 

  • Lange RW, Germolec DR, Foley JF, Luster MI (1998) Antioxidants attenuate anthralin-induced skin inflammation in BALB/c mice: role of specific proinflammatory cytokines. J Leukocyte Biol 64:170–176

    PubMed  CAS  Google Scholar 

  • Nakao I, Uchino H, Kaido I, Kimura T, Goto Y, Kondo T, Takino T, Taguchi T, Nakajima T, Fujimoto S, Miyazaki T, Miyoshi A, Yachi A, Yoshida K, Ogawa N, Furue H (1983) Clinical evaluation of schizophyllan (SGP) in advanced gastric cancer – a randomized comparative study by an envelop method. Jpn J Cancer Chemotherap 10:1146–1159

    CAS  Google Scholar 

  • Novak M, Vetvicka V (2008) β-Glucans, history, and the present: Immunomodulatory aspects and mechanisms of action. J Immunotoxicol 5:47–57

    Article  PubMed  CAS  Google Scholar 

  • Novak M, Vetvicka V (2009) β-Glucans as biological response modifiers. Endocrine Metabol Immune Disorders-Drug Targets 9:67–75

    Article  CAS  Google Scholar 

  • Pillemer L, Ecker EE (1941) Anticomplementary factor in fresh yeast. J Biol Chem 137:139–42

    CAS  Google Scholar 

  • Pillemer L, Schoenberg MD, Blum L, Wurz L (1955) Properdin system and immunity. II. Interaction of the properdin system with polysaccharides. Science 122:545–9

    Article  PubMed  CAS  Google Scholar 

  • Poulain-Godefroy O, Le Bacquer O, Plancq P, Lecour C, Pattou F, Fruhbeck G, Froguel P (2010) Inflammatory role of Toll-like receptors in human and murine adipose tissue. Med Inflamm doi:10.1155/2010/823486.

  • Ramprasath VR, Shanthi P, Sachdanandam P (2006) Immunomodulatory and anti-inflammatory effects of Semecarpus anacardium LINN. Nut milk extract in experimental inflammatory conditions. Biol Pharm Bull 29:693–700

    Article  PubMed  CAS  Google Scholar 

  • Rayalam S, Yang JY, Della-Fera MA, Park HJ, Ambati S, Baile CA (2009) Anti-obesity effects of xanthohumol plus guggulsterone in 3T3-L1 adipocytes. J Med Food 12:843–853

    Article  Google Scholar 

  • Schepetkin IA, Quinn MT (2006) Botanical polysaccharides: macrophage immunomodulation and therapeutical potential. Int Immunopharmacol 6:317–333

    Article  PubMed  CAS  Google Scholar 

  • Shear MJ, Turner FC (1943) Chemical treatment of tumours. V. Isolation of the hemorrhage-producing fraction from Serratia marcescens (Bacillus prodigiosus) culture filtrate. J Natl Cancer Inst 4:81–97

    CAS  Google Scholar 

  • Tietyen JL, Nevins DJ, Schneeman BO (1990) Characterization of the hypocholesterolemic potential of oat brand. FASEB J 4:A527

    Google Scholar 

  • Vashishta A, Saraswat Ohri S, Vetvickova J, Fusek M, Ulrichova J, Vetvicka V (2007) Procathepsin D secreted by HaCaT keratinocyte cells—a novel regulator of keratinocyte growth. Eur J Cell Biol 86:303–313

    Article  PubMed  CAS  Google Scholar 

  • Vetvicka V, Novak M (2011) Biological action of β-glucan. In: Vetvicka V, Novak M (ed) Biology and chemistry of Beta Glucan, vol. 1: beta glucans–mechanisms of action. Bentham Press, p10–25

  • Vetvicka V, Vancikova Z (2010) Anti-stress action of several orally-given β-glucans. Biomed Pap 154:235–238

    CAS  Google Scholar 

  • Vetvicka V, Vetvickova J (2008) A comparison of injected and orally administered β-glucans. J American Nutr Assoc 11:42–49

    Google Scholar 

  • Vetvicka V, Vetvickova J (2009) Effect of yeast-derived β-glucans on blood cholesterol and macrophage functionality. J Immunotoxicol 6:30–35

    Article  PubMed  CAS  Google Scholar 

  • Vetvicka V, Vetvickova J (2010) β1,3-glucan: silver bullet or hot air? Open Glycosci 3:1–6

    CAS  Google Scholar 

  • Vetvicka V, Thornton BP, Ross GD (1996) Soluble β-glucan polysaccharide binding to the lectin site of neutrophil or natural killer cell complement receptor type 3 (CD11b/CD18) generates a primed state of the receptor capable of mediating cytotoxicity of iC3b-opsonized target cells. J Clin Invest 98:50–61

    Article  PubMed  CAS  Google Scholar 

  • Wei D, Zhang L, Williams DL, Browder IW (2002) Glucan stimulates human dermal fibroblast collagen biosynthesis through a nuclear factor-1 dependent mechanism. Wound Repair Regen 10:161–168

    Article  PubMed  Google Scholar 

  • Willment JA, Gordon S, Brown GD (2001) Characterization of the human beta -glucan receptor and its alternatively spliced isoforms. J Biol Chem 276:43818–43823

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Pathology, University of Louisville, Louisville, KY, 40202, USA

    Vaclav Vetvicka & Jana Vetvickova

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  1. Vaclav Vetvicka
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  2. Jana Vetvickova
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Correspondence to Vaclav Vetvicka.

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Vetvicka, V., Vetvickova, J. β(1-3)-D-glucan affects adipogenesis, wound healing and inflammation. Orient Pharm Exp Med 11, 169–175 (2011). https://doi.org/10.1007/s13596-011-0024-4

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