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Advances in mesenchymal stem/stromal cell-based therapy and their extracellular vesicles for skin wound healing

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Abstract

Wound healing is a dynamic and complicated process containing overlapping phases. Presently, definitive therapy is not available, and the investigation into optimal wound care is influenced by the efficacy and cost-effectiveness of developing therapies. Accumulating evidence demonstrated the potential role of mesenchymal stem/stromal cell (MSC) therapy in several tissue injuries and diseases due to their high proliferation and differentiation abilities along with an easy collection procedure, low tumorigenesis, and immuno‐privileged status. MSCs have also accelerated wound repair in all phases through their advantageous properties, such as accelerating wound closure, improving re-epithelialization, elevating angiogenesis, suppressing inflammation, and modulating extracellular matrix (ECM) remodeling. In addition, the beneficial therapeutic impacts of MSCs are largely associated with their paracrine functions, including extracellular vesicles (EVs). Exosomes and microvesicles are the two main subgroups of EVs. These vesicles are heterogeneous bilayer membrane structures that contain several proteins, lipids, and nucleic acids. EVs have emerged as a promising alternative to stem cell-based therapies because of their lower immunogenicity, tumorigenicity, and ease of management. MSCs from various sources have been widely investigated in skin wound healing and regeneration. Considering these features, in this review, we highlighted recent studies that the investigated therapeutic potential of various MSCs and MSC-EVs in skin damages and wounds.

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  1. Faculty of Pharmacy, Middle East University, Amman, 11831, Jordan

    Mohamed J. Saadh

  2. Applied Science Research Center, Applied Science Private University, Amman, Jordan

    Mohamed J. Saadh

  3. Azogues Campus Nursing Career, Health and Behavior Research Group (HBR), Psychometry and Ethology Laboratory, Catholic University of Cuenca, Cuenca, Ecuador

    Andrés Alexis Ramírez-Coronel

  4. Epidemiology and Biostatistics Research Group, CES University, Medellín, Colombia

    Andrés Alexis Ramírez-Coronel

  5. COAMS, King Khalid University, Abha, Saudi Arabia

    Ravinder Singh Saini

  6. Department of Social Sciences, Faculty of Social Studies, Pontifical University of Peru, San Miguel, Peru

    José Luis Arias-Gonzáles

  7. Zoology Department, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt

    Ali H. Amin

  8. Universidad Privada del Norte, Lima, Lima, Peru

    Juan Carlos Orosco Gavilán

  9. 2nd Department of Surgery, Pediatric Surgery and Orthopedics, “Grigore T. Popa”, University of Medicine and Pharmacy, 700115, Iași, Romania

    Ioan Sârbu

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  1. Mohamed J. Saadh
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  2. Andrés Alexis Ramírez-Coronel
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  3. Ravinder Singh Saini
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  4. José Luis Arias-Gonzáles
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  5. Ali H. Amin
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  6. Juan Carlos Orosco Gavilán
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  7. Ioan Sârbu
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Correspondence to Ioan Sârbu.

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Saadh, M.J., Ramírez-Coronel, A.A., Saini, R.S. et al. Advances in mesenchymal stem/stromal cell-based therapy and their extracellular vesicles for skin wound healing. Human Cell 36, 1253–1264 (2023). https://doi.org/10.1007/s13577-023-00904-8

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