Skip to main content

Advertisement

SpringerLink
Log in

Immunohistochemical expression of nicotinamide N-methyltransferase in lymph node metastases from cutaneous malignant melanoma

  • Letter to the Editor
  • Published:
Human Cell Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Leiter U, Keim U, Garbe C. Epidemiology of skin cancer: update 2019. Adv Exp Med Biol. 2020;1268:123–39.

    Article  CAS  Google Scholar 

  2. Leonardi GC, Falzone L, Salemi R, Zanghi A, Spandidos DA, McCubey JA, et al. Cutaneous melanoma: from pathogenesis to therapy (review). Int J Oncol. 2018;52:1071–80.

    CAS  Google Scholar 

  3. Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2021. CA Cancer J Clin. 2021;71:7–33.

    Article  Google Scholar 

  4. Campagna R, Pozzi V, Sartini D, Salvolini E, Brisigotti V, Molinelli E, et al. Beyond nicotinamide metabolism: potential role of nicotinamide N-methyltransferase as a biomarker in skin cancers. Cancers. 2021;13:4943–54.

    Article  CAS  Google Scholar 

  5. Parsons RB, Facey PD. Nicotinamide N-methyltransferase: an emerging protagonist in cancer macro(r)evolution. Biomolecules. 2021;11:1418–46.

    Article  CAS  Google Scholar 

  6. Togni L, Mascitti M, Sartini D, Campagna R, Pozzi V, Salvolini E, et al. Nicotinamide N-Methyltransferase in head and neck tumors: a comprehensive review. Biomolecules. 2021;11:1594–608.

    Article  CAS  Google Scholar 

  7. Campagna R, Salvolini E, Pompei V, Pozzi V, Salvucci A, Molinelli E, et al. Nicotinamide N-methyltransferase gene silencing enhances chemosensitivity of melanoma cell lines. Pigment Cell Melanoma Res. 2021;34:1039–48.

    Article  CAS  Google Scholar 

  8. Pompei V, Salvolini E, Rubini C, Lucarini G, Molinelli E, Brisigotti V, et al. Nicotinamide N-methyltransferase in nonmelanoma skin cancers. Eur J Clin Invest. 2019;49: e13175.

    Article  CAS  Google Scholar 

  9. Ganzetti G, Sartini D, Campanati A, Rubini C, Molinelli E, Brisigotti V, et al. Nicotinamide N-methyltransferase: potential involvement in cutaneous malignant melanoma. Melanoma Res. 2018;28:82–8.

    Article  CAS  Google Scholar 

  10. Tang SW, Yang TC, Lin WC, Chang WH, Wang CC, Lai MK, et al. Nicotinamide N-methyltransferase induces cellular invasion through activating matrix metalloproteinase-2 expression in clear cell renal cell carcinoma cells. Carcinogenesis. 2011;32:138–45.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors would like to thank Dr. Donatella Diotallevi (Unit of Pathologic Anatomy and Histopathology, Department of Biomedical Sciences and Public Health, Marche Polytecnhic University, United Ancona Hospitals, Ancona, Italy) for her support.

Funding

The authors did not receive support from any organization for this study.

Author information

Author notes

  1. Davide Sartini and Elisa Molinelli have contributed equally to this work.

Authors and Affiliations

  1. Department of Clinical Sciences, Marche Polytechnic University, Ancona, Italy

    Davide Sartini, Valentina Pozzi, Roberto Campagna, Eleonora Salvolini & Monica Emanuelli

  2. Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy

    Elisa Molinelli, Oriana Simonetti, Anna Campanati & Annamaria Offidani

  3. Department of Biomedical Sciences and Public Health, Marche Polytechnic University, Ancona, Italy

    Corrado Rubini & Gaia Goteri

  4. New York-Marche Structural Biology Center (NY-MaSBiC), Marche Polytechnic University, Ancona, Italy

    Monica Emanuelli

Authors
  1. Davide Sartini
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Elisa Molinelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Valentina Pozzi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Roberto Campagna
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Eleonora Salvolini
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Corrado Rubini
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Gaia Goteri
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Oriana Simonetti
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Anna Campanati
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Annamaria Offidani
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Monica Emanuelli
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

DS and EM: writing-original draft preparation, methodology; VP: data curation; RC: software; ES: writing-review and editing, project administration; CR: visualization, formal analysis; GG: resources; OS: funding acquisition; AC: validation; AO: conceptualization, supervision; ME: conceptualization, supervision; writing-review and editing. All authors read and approved the final version of the manuscript.

Corresponding author

Correspondence to Eleonora Salvolini.

Ethics declarations

Conflict of interest

The authors have no conflicts of interest to declare.

Ethical approval

This retrospective study was performed on formalin-fixed and paraffin-embedded tissue specimens, previously collected for diagnostic purposes. According to the Ethics Committee of the Marche region ethical approval for retrospective studies is not required; it is sufficient to send a notification.

Informed consent

All participants gave their informed consent.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sartini, D., Molinelli, E., Pozzi, V. et al. Immunohistochemical expression of nicotinamide N-methyltransferase in lymph node metastases from cutaneous malignant melanoma. Human Cell 36, 480–482 (2023). https://doi.org/10.1007/s13577-022-00793-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13577-022-00793-3

Keywords

Search

Navigation