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The role of TNF-α induced protein 1 in the activation of pro-apoptotic proteins

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Abstract

It is known that Porphyromonas gingivalis/lipopolysaccharide (P. gingivalis/LPS) induces inflammatory diseases via TNF-α-mediated transcription factors. Our recent data shows that TNFAIP1 (TNF-α induced protein 1) is related to TNF-α. However, little is known regarding how TNFAIP1 is involved in the TNF-α-dependent pathway. We therefore focused on the biological function of TNFAIP1 and examined how TNFAIP1 mediates TNF-α and other genes. We found that TNF-α was upregulated and peaks before the upregulation of apoptotic genes such as Bad, Bcl-x, Caspase 3, Catalase, Claspin, Cytochromic, Ho-1/HMOX1/HSP32, or MCI-1 in our time course with TNFAIP1-treated cells. Our findings here may serve as the foundation for future studies linking regulation of TNFAIP1 and intervention of inflammatory disease.

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Abbreviations

P.g :

Porphyromonas gingivalis

LPS:

Lipopolysaccharide

TNFAIP1:

TNF-α induced protein 1

MAP:

Mitogen-activated protein

PI3K:

Phosphoinositide 3-kinase

NF-kB:

Nuclear factor kappa B

LITA:

LPS-induced TNF-α factor

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Funding

This research did not receive any specific grants from funding agencies in the public, commercial, or not-profit sectors.

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Author notes

  1. Thanarut Tangkham, Bushra Aliahdali contributed equally to the experiments of this study.

Authors and Affiliations

  1. Henry M. Goldman School of Dental Medicine, Department of Periodontology, Boston University, 650 Albany Street, Boston, MA, USA

    Xiaoren Tang, Thanarut Tangkham, Bushra Aljahdali, Sean Lee, Mingfang Su & Serge Dibart

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  1. Xiaoren Tang
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  2. Thanarut Tangkham
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  3. Bushra Aljahdali
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  4. Sean Lee
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  5. Mingfang Su
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  6. Serge Dibart
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Contributions

XT, MS, and SD designed this study; XT, TT, and BA performed experiments; XT, TT, and BA collected and further analyzed data; XT and TT drafted the manuscript; all authors revised and approved this manuscript.

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Correspondence to Xiaoren Tang.

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Tang, X., Tangkham, T., Aljahdali, B. et al. The role of TNF-α induced protein 1 in the activation of pro-apoptotic proteins. Human Cell 34, 1123–1129 (2021). https://doi.org/10.1007/s13577-021-00529-9

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  • DOI: https://doi.org/10.1007/s13577-021-00529-9

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