Abstract
Circular RNAs (circRNAs) exert pivotal effects on regulating the progression of osteosarcoma (OS). It was found through microarray analysis that circ-0002052 is abnormally expressed in OS, but the role of circ-0002052 in OS remains obscure. The results of this research manifested that relative to that in non-tumor controls, circ-0002052 level was raised in OS tissues. Up-regulated circ-0002052 was associated with advanced stage, tumor size, and metastasis. Additionally, circ-0002052 elevation indicated a low survival rate in OS patients and silencing of circ-0002052 suppressed proliferation, migration, and invasion of OS cells. It was proved that circ-0002052 sponged miR-382 and stimulated STX6 expression, thus activating Wnt/β-catenin. The function of circ-0002052 reduction in OS cells was effectively reversed by miR-382 suppression. To sum up, it can be concluded that circ-0002052, functioning as a sponge for miR-382, enhances the activation of Wnt/β-catenin mediated by STX6 to stimulate the progression of OS, and circ-0002052 may be an underlying treatment target and a biomarker for prognosis of osteosarcoma.
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The datasets used and/or analyzed during the present study are available from the corresponding author on reasonable request.
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PZ made substantial contributions to conception and design. JR, RS, and YL made acquisition of data. PZ and JR performed the experiments. JW and RS wrote the draft manuscript. All authors contributed to the reviewing of the manuscript, and approved the final manuscript for submission.
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Zhang, Pr., Ren, J., Wan, Js. et al. Circular RNA hsa_circ_0002052 promotes osteosarcoma via modulating miR-382/STX6 axis. Human Cell 33, 810–818 (2020). https://doi.org/10.1007/s13577-020-00335-9
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DOI: https://doi.org/10.1007/s13577-020-00335-9