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Function of innate lymphoid cells in the immune-related disorders

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Abstract

Innate lymphoid cells (ILCs) are a recently described group of innate immune cells that mirror the characteristics of CD4+ T cell subsets. Based on their transcriptional factor and cytokine profile, ILCs family is divided into main subgroups—ILC1s, ILC2s, and ILC3s. Recently, one new subpopulation of ILCs with immunosuppressive characteristics has been described and named as regulatory ILCs. Various roles of ILCs have been confirmed including the role during the response to microbial signals, the role in inflammation and process of tissue repair. Function of ILCs is mediated through the cytokines production and direct cell-to-cell contact. This article summarizes in detail, the relationship between the ILCs and various immune-related disorders.

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Acknowledgements

The authors thank the support of the Ministry of Education, Science and Technological Development of the Republic of Serbia (projects numbers 175102, 175056).

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  1. Institute of Biomedical Research, Faculty of Medicine, University of Niš, Nis, Serbia

    Tanja Dzopalić

  2. Faculty of Biology, University of Belgrade, Belgrade, Serbia

    Biljana Božić-Nedeljković

  3. Faculty of Medical Sciences, University of Kragujevac, P. BOX 124, Kragujevac, 34 000, Serbia

    Vladimir Jurišić

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Dzopalić, T., Božić-Nedeljković, B. & Jurišić, V. Function of innate lymphoid cells in the immune-related disorders. Human Cell 32, 231–239 (2019). https://doi.org/10.1007/s13577-019-00257-1

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