Skip to main content

Advertisement

SpringerLink
Log in

MiR-192-5p suppresses the growth of bladder cancer cells via targeting Yin Yang 1

  • Research Article
  • Published:
Human Cell Aims and scope Submit manuscript

Abstract

Bladder cancer has been identified as one of the most malignant cancers with high incidence and mortality. The underlying mechanisms by which regulate the tumorigenesis of bladder cancer deserve further investigation. Here, we found that miR-192-5p was downregulated in human bladder cancer cell lines and tissues. Overexpression of miR-192-5p significantly inhibited the growth of bladder cancer cells, while depletion of miR-192-5p exerted opposite effect. Bioinformatics analysis and molecular mechanism study identified that miR-192-5p targeted the transcription factor Yin Yang 1 (YY1) and decreased the expression level of YY1. Highly expressed YY1 attenuated the potential tumor suppressive function of miR-192-5p. The expression of miR-192-5p was negatively correlated with that of YY1 in bladder cancer tissues. These results indicated that miR-192-5p might serve as a promising target in bladder cancer diagnosis and therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Gordetsky J, Collingwood R, Lai WS, Del Carmen Rodriquez Pena M, Rais-Bahrami S. Second opinion expert pathology review in bladder cancer: implications for patient care. Int J Surg Pathol. 2017;26:12–7. https://doi.org/10.1177/1066896917730903.

    Article  PubMed  Google Scholar 

  2. Katafigiotis I, Sfoungaristos S, Martini A, Stravodimos K, Anastasiou I, Mykoniatis I, et al. Bladder cancer to patients younger than 30 years: a retrospective study and review of the literature. Urologia. 2017;84:231–5. https://doi.org/10.5301/uj.5000264.

    Article  PubMed  Google Scholar 

  3. Kutwin P, Konecki T, Cichocki M, Falkowski P, Jablonowski Z. Photodynamic diagnosis and narrow-band imaging in the management of bladder cancer: a review. Photomed Laser Surg. 2017;35(9):459–64. https://doi.org/10.1089/pho.2016.4217.

    Article  PubMed  Google Scholar 

  4. Tang X, Du P, Yang Y. The clinical use of neutrophil-to-lymphocyte ratio in bladder cancer patients: a systematic review and meta-analysis. Int J Clin Oncol. 2017. https://doi.org/10.1007/s10147-017-1171-5.

    Article  PubMed  Google Scholar 

  5. Kaufman DS, Shipley WU, Feldman AS. Bladder cancer. Lancet. 2009;374(9685):239–49. https://doi.org/10.1016/S0140-6736(09)60491-8.

    Article  PubMed  CAS  Google Scholar 

  6. Cilek EE, Ozturk H, Gur Dedeoglu B. Construction of miRNA-miRNA networks revealing the complexity of miRNA-mediated mechanisms in trastuzumab treated breast cancer cell lines. PLoS One. 2017;12(10):e0185558. https://doi.org/10.1371/journal.pone.0185558.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Lee S, Jiang X. Modeling miRNA-mRNA interactions that cause phenotypic abnormality in breast cancer patients. PLoS One. 2017;12(8):e0182666. https://doi.org/10.1371/journal.pone.0182666.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. Pradhan AK, Emdad L, Das SK, Sarkar D, Fisher PB. The enigma of miRNA regulation in cancer. Adv Cancer Res. 2017;135:25–52. https://doi.org/10.1016/bs.acr.2017.06.001.

    Article  PubMed  Google Scholar 

  9. Wang K, Chen M, Wu W. Analysis of microRNA (miRNA) expression profiles reveals 11 key biomarkers associated with non-small cell lung cancer. World J Surg Oncol. 2017;15(1):175. https://doi.org/10.1186/s12957-017-1244-y.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Yang F, Ning Z, Ma L, Liu W, Shao C, Shu Y, et al. Exosomal miRNAs and miRNA dysregulation in cancer-associated fibroblasts. Mol Cancer. 2017;16(1):148. https://doi.org/10.1186/s12943-017-0718-4.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Yu Y, Nangia-Makker P, Farhana L, Majumdar APN. A novel mechanism of lncRNA and miRNA interaction: cCAT2 regulates miR-145 expression by suppressing its maturation process in colon cancer cells. Mol Cancer. 2017;16(1):155. https://doi.org/10.1186/s12943-017-0725-5.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Blanca A, Cheng L, Montironi R, Moch H, Massari F, Fiorentino M, et al. Mirna expression in bladder cancer and their potential role in clinical practice. Curr Drug Metab. 2017. https://doi.org/10.2174/1389200218666170518164507.

    Article  PubMed  Google Scholar 

  13. Braicu OL, Budisan L, Buiga R, Jurj A, Achimas-Cadariu P, Pop LA, et al. miRNA expression profiling in formalin-fixed paraffin-embedded endometriosis and ovarian cancer samples. Onco Targets Ther. 2017;10:4225–38. https://doi.org/10.2147/OTT.S137107.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Chen Y, Min L, Ren C, Xu X, Yang J, Sun X, et al. miRNA-148a serves as a prognostic factor and suppresses migration and invasion through Wnt1 in non-small cell lung cancer. PLoS One. 2017;12(2):e0171751. https://doi.org/10.1371/journal.pone.0171751.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  15. Chen Y, Yang X, Xu Y, Cao J, Chen L. Genomic analysis of drug resistant small cell lung cancer cell lines by combining mRNA and miRNA expression profiling. Oncol Lett. 2017;13(6):4077–84. https://doi.org/10.3892/ol.2017.5967.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  16. Daniunaite K, Dubikaityte M, Gibas P, Bakavicius A, Rimantas Lazutka J, Ulys A, et al. Clinical significance of miRNA host gene promoter methylation in prostate cancer. Hum Mol Genet. 2017;26(13):2451–61. https://doi.org/10.1093/hmg/ddx138.

    Article  PubMed  CAS  Google Scholar 

  17. Eissa S, Habib H, Ali E, Kotb Y. Evaluation of urinary miRNA-96 as a potential biomarker for bladder cancer diagnosis. Med Oncol. 2015;32(1):413. https://doi.org/10.1007/s12032-014-0413-x.

    Article  PubMed  CAS  Google Scholar 

  18. Yang X, Shi L, Yi C, Yang Y, Chang L, Song D. MiR-210-3p inhibits the tumor growth and metastasis of bladder cancer via targeting fibroblast growth factor receptor-like 1. Am J Cancer Res. 2017;7(8):1738–53.

    PubMed  PubMed Central  Google Scholar 

  19. Shi HB, Yu JX, Yu JX, Feng Z, Zhang C, Li GY, et al. Diagnostic significance of microRNAs as novel biomarkers for bladder cancer: a meta-analysis of ten articles. World J Surg Oncol. 2017;15(1):147. https://doi.org/10.1186/s12957-017-1201-9.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Yan-Chun L, Hong-Mei Y, Zhi-Hong C, Qing H, Yan-Hong Z, Ji-Fang W. MicroRNA-192-5p promote the proliferation and metastasis of hepatocellular carcinoma cell by targeting SEMA3A. Appl Immunohistochem Mol Morphol. 2015. https://doi.org/10.1097/PAI.0000000000000296.

    Article  Google Scholar 

  21. Zou YF, Wen D, Zhao Q, Shen PY, Shi H, Zhao Q, et al. Urinary MicroRNA-30c-5p and MicroRNA-192-5p as potential biomarkers of ischemia–reperfusion-induced kidney injury. Exp Biol Med. 2017;242(6):657–67. https://doi.org/10.1177/1535370216685005.

    Article  CAS  Google Scholar 

  22. Zhang Y, Huang R, Zhou W, Zhao Q, Lu Z. miR-192-5p mediates hypoxia/reoxygenation-induced apoptosis in H9c2 cardiomyocytes via targeting of FABP3. J Biochem Mol Toxicol. 2017;31(4). https://doi.org/10.1002/jbt.21873.

  23. Jin H, Qiao F, Wang Y, Xu Y, Shang Y. Curcumin inhibits cell proliferation and induces apoptosis of human non-small cell lung cancer cells through the upregulation of miR-192-5p and suppression of PI3K/Akt signaling pathway. Oncol Rep. 2015;34(5):2782–9. https://doi.org/10.3892/or.2015.4258.

    Article  PubMed  CAS  Google Scholar 

  24. Epstein JI, Amin MB, Reuter VR, Mostofi FK. The World Health Organization/International Society of Urological Pathology consensus classification of urothelial (transitional cell) neoplasms of the urinary bladder. Bladder Consensus Conference Committee. Am J Surg Pathol. 1998;22(12):1435–48.

    Article  PubMed  CAS  Google Scholar 

  25. Shuang Y, Li C, Zhou X, Huang Y, Zhang L. MicroRNA-195 inhibits growth and invasion of laryngeal carcinoma cells by directly targeting DCUN1D1. Oncol Rep. 2017;38(4):2155–65. https://doi.org/10.3892/or.2017.5875.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Han Q, Lin X, Zhang X, Jiang G, Zhang Y, Miao Y, et al. WWC3 regulates the Wnt and Hippo pathways via Dishevelled proteins and large tumour suppressor 1, to suppress lung cancer invasion and metastasis. J Pathol. 2017;242(4):435–47. https://doi.org/10.1002/path.4919.

    Article  PubMed  CAS  Google Scholar 

  27. Sun X, Zhang L. MicroRNA-143 suppresses oral squamous cell carcinoma cell growth, invasion and glucose metabolism through targeting hexokinase 2. Biosci Rep. 2017;37(3). https://doi.org/10.1042/bsr20160404.

  28. Li W, Yang W, Liu Y, Chen S, Chin S, Qi X, et al. MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma. Oncotarget. 2017;8(43):73938–46. https://doi.org/10.18632/oncotarget.17881.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Liu W, Wang S, Zhou S, Yang F, Jiang W, Zhang Q, et al. A systems biology approach to identify microRNAs contributing to cisplatin resistance in human ovarian cancer cells. Mol BioSyst. 2017. https://doi.org/10.1039/c7mb00362e.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Aschenbrenner DS. Updated review confirms potential risk of bladder cancer with pioglitazone. Am J Nurs. 2017;117(4):25. https://doi.org/10.1097/01.NAJ.0000515230.35655.54.

    Article  PubMed  Google Scholar 

  31. Traboulsi SL, Brimo F, Yang Y, Maedler C, Prevost N, Tanguay S, et al. Pathology review impacts clinical management of patients with T1-T2 bladder cancer. Can Urol Assoc J. 2017;11(6):188–93. https://doi.org/10.5489/cuaj.4126.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Xie Y, Ma X, Chen L, Li H, Gu L, Gao Y, et al. MicroRNAs with prognostic significance in bladder cancer: a systematic review and meta-analysis. Sci Rep. 2017;7(1):5619. https://doi.org/10.1038/s41598-017-05801-3.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  33. Ye M, Zhang J, Zhang J, Miao Q, Yao L, Zhang J. Curcumin promotes apoptosis by activating the p53-miR-192-5p/215-XIAP pathway in non-small cell lung cancer. Cancer Lett. 2015;357(1):196–205. https://doi.org/10.1016/j.canlet.2014.11.028.

    Article  PubMed  CAS  Google Scholar 

  34. Atchison M, Basu A, Zaprazna K, Papasani M. Mechanisms of Yin Yang 1 in oncogenesis: the importance of indirect effects. Crit Rev Oncog. 2011;16(3–4):143–61.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Zheng L, Chen Y, Ye L, Jiao W, Song H, Mei H, et al. miRNA-584-3p inhibits gastric cancer progression by repressing Yin Yang 1-facilitated MMP-14 expression. Sci Rep. 2017;7(1):8967. https://doi.org/10.1038/s41598-017-09271-5.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. First Urology, Cangzhou Central Hospital, No. 16, West of Xin Hua Street, Cangzhou, Hebei, China

    Decai Ji, Lining Jiang & Yingjie Li

Authors
  1. Decai Ji
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lining Jiang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yingjie Li
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Decai Ji.

Ethics declarations

Conflict of interest

The authors declare that they have no conflicts of interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ji, D., Jiang, L. & Li, Y. MiR-192-5p suppresses the growth of bladder cancer cells via targeting Yin Yang 1. Human Cell 31, 210–219 (2018). https://doi.org/10.1007/s13577-018-0201-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13577-018-0201-6

Keywords

Search

Navigation