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Ameliorative effects of Bauhinia acuminata L stem bark powder against chronic arsenicosis in rats

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Abstract

Arsenic poisoning is one of the major causes of chronic human illness and mortality in Bengal Delta plain with limited treatment option. The present study was conducted to evaluate the ameliorating effect of Bauhinia acuminata L (Leguminosae: Caesalpinioideae) stem-bark powder against sodium arsenite (NaAsO2) induced toxicity. Forty eight adult albino rats were divided into four groups viz., D0, D1, D2 and D3. Sodium arsenite was administered @4 mg/kg daily in drinking water in groups D1, D2 and D3 for 90 days; control group (D0) received water for 120 days. The D1 group of animals received water, instead of arsenic during 91-120 days, while rats of group D2 and D3 were orally treated with stem bark powder @350 mg/kg (1/10 th dose of LD50) and 175 mg/kg (1/20 th dose of LD50) respectively daily during the period. Analysis of arsenic concentrations in tissue samples, hair and faeces showed that treatment with B. acuminata stem bark powder significantly (p<0.05) reduced arsenic accumulation in tissues, hair and in faeces. A significantly (p<0.05) higher organo-arsenic fraction and lower arsenite and arsenate fractions was also observed in B. acuminata stem bark powder treated group (D2 and D3). The study showed that oral treatment with B. acuminata stem bark powder could ameliorate induced arsenicosis.

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Authors and Affiliations

  1. BCDA College of Pharmacy & Technology, Hridaypur, Barasat, India

    Amartya De

  2. Department of Pharmacology, R.G.Kar Medical College and Hospital, Kolkata, India

    Sarmila Nath & Anup Kumar Das

  3. Director of Medical Education, West Bengal, Kolkata, India

    Susanta Kumar Bandyopadhyay

  4. Department of Veterinary Pharmacology & Toxicology, WBUAFS, Kolkata, India

    Tapan Kumar Mandal

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  1. Amartya De
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  2. Sarmila Nath
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  3. Susanta Kumar Bandyopadhyay
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  4. Tapan Kumar Mandal
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  5. Anup Kumar Das
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Correspondence to Amartya De.

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De, A., Nath, S., Bandyopadhyay, S.K. et al. Ameliorative effects of Bauhinia acuminata L stem bark powder against chronic arsenicosis in rats. Toxicol. Environ. Health Sci. 8, 258–262 (2016). https://doi.org/10.1007/s13530-016-0283-z

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  • DOI: https://doi.org/10.1007/s13530-016-0283-z

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