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Eco-toxicological and epidemiological assessment of human exposure to polycyclic aromatic hydrocarbons in the Niger Delta, Nigeria

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Abstract

Epidemiological examinations of polycyclic aromatic hydrocarbons (PAHs) exposure in biological bodies have shown the potential risk of cancer induction. Environmental media containing PAHs were analyzed in the Niger Delta region. Gas chromatographicmass spectrometric analyses were carried out on samples and 98% of the samples contained carcinogenic PAHs. The concentration of the 7 potential carcinogenic PAHs (Σ soilcarc 7PAHs) in the soils varied from 297–4080.6±546.3 mg/kg (min-max +/- standard deviation) with a median of 419 mg/kg, the concentrations for non-carcinogenic PAHs ranged from 315–1999±300 mg/kg with a median of 497.5 mg/kg. The total concentrations of PAHs (»total H2O17PAHs) in water samples varied from 119.8–450.0±117.9 mg/L with a median of 141.9 mg/L, while the sediment concentrations ranged from 6.0–132.0±28.7 mg/L with a median of 62.73 mg/L. Concentrations of benzo(a) pyrene (BaP), which most likely originated from crude oil spillage in the area was determined as 66.95±73.47 mg/kg in soil samples. To evaluate human exposure to carcinogenic PAHs sources, the toxic equivalence factors (TEFs), mutagenic potency equivalent factors (MEFs) and the incremental lifetime cancer risk (ILCR) methodologies were used to calculate the exposure risk. Carcinogenic equivalents (BaP-TEQ) and mutagenic equivalents (BaP-MEQ) were calculated from the potency relative to BaP (TEF) and BAP (MEF) respectively. BaP-TEQ (mg/kg) for Ω soilcarc 7PAHs were determined as 98.80±125.81 and varied from 68.20–953.84 mg/kg, while the BaPMEQ (mg/kg) for Σ soilcarc 7PAHs were determined as 124.01±163.37 and varied from 87.24–1237.82 mg/ kg. The BaP-TEQ (mg/kg) for Ω H2Ocarc 7PAHs were determined as 16.79±14.44 and varied from 5.55–52.69 mg/L, similarly the BaP-MEQ (mg/kg) for Ω H2Ocarc 7PAHs were determined as 9.29±8.15 and varied from 1.55–29.80 mg/kg. The cumulative ILCR from the water and soil contaminations were determined as 1.13×10−4 and 6.42×10−4 respectively for children, while values of 1.09×10−4 and 6.19×10−4 were determined respectively for adult. The ecotoxicological assessments in this study indicate contamination of environmental media in the region with high potential of acute toxicity sufficient enough to induce carcinogenic effects and chronically affect the human health of residents with prolonged exposures.

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References

  1. Khan, F. I. & Sadiq, R. Risk-based prioritization of air pollution monitoring using fuzzy synthetic evaluation technique. Environ. Monit. Assess. 105, 261–283 (2005).

    Article  PubMed  CAS  Google Scholar 

  2. Xiaoxing, L. & Takashi, K. Dynamic analysis for the distribution of polycyclic aromatic hydrocarbons in rice. J. Health Sci. 47, 446–451 (2001).

    Article  Google Scholar 

  3. Stefanova, M., Marinov, S. P., Mastral, A. M., Callen, M. S. & Garci, T. Emission of oxygen, sulphur and nitrogen containing heterocyclic polyaromatic compounds from lignite combustion. Fuel Process. Technol. 77–78, 89–94 (2002).

    Article  Google Scholar 

  4. Watson, A. P. & Dolislager, F. D. Reevalution of 1999 Health-Based Environmental Screening Levels (HBESLs) for Chemical Warfare Agents. ORNL/TM-2007/080 (2007).

  5. International Agency for Research on Cancer (IARC). Overall Evaluations of Carcinogenicity: an Updating of IARC Monographs. Lyon, France: International Agency for Research on Cancer (1987).

    Google Scholar 

  6. Wilcke, W. Polycyclic aromatic hydrocarbons (PAHs) in soil-A review. J. Plant Nutr. Soil Sci. 163, 229–248 (2000).

    Article  CAS  Google Scholar 

  7. Mandalakis, M. et al. Contribution of biomass burning to atmospheric polycyclic aromatic hydrocarbons at three european background sites. Environ. Sci. Technol. 39, 2976–2982 (2005).

    Article  PubMed  CAS  Google Scholar 

  8. Lee, R. G. M., Coleman, P., Jones, J. L., Jones, K. C. & Lohmann, R. Emission factors and importance of PCDD/Fs, PCBs, PCNs, PAHs and PM10 from the domestic burning of coal and wood in the U.K. Environ. Sci. Technol. 39, 1436–1447 (2005).

    Article  PubMed  CAS  Google Scholar 

  9. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Polycyclic Aromatic Compounds. Atlanta, GA, USA: US Department of Health and Human Services, Public Health Service (1995).

    Google Scholar 

  10. Dunbar, J. C., Lin, C. I., Vergucht, I., Wong, J. & Durant, J. L. Estimating the contributions of mobile sources of PAH to urban air using real-time PAH monitoring. Sci. Total Environ. 279, 1–19 (2001).

    Article  PubMed  CAS  Google Scholar 

  11. Kuo, H. W., Lo, I. I., Chan, C. C., Lai, J. S. & Wang, J. D. Volatile organic compounds in water near petrochemical factories in Taiwan. Chemosphere 33, 913–920 (1996).

    Article  CAS  Google Scholar 

  12. Cetin, E., Odabasi, M. & Seyfioglu, R. Ambient volatile organic compound (VOC) concentrations around a petrochemical complex and a petroleum refinery. Sci. Total Environ. 312, 103–112 (2003).

    Article  PubMed  CAS  Google Scholar 

  13. Brun, G. L, Vaidya, O. C., Léger, M. G. Atmospheric deposition of polycyclic aromatic hydrocarbons to atlantic Canada: Geographic and temporal distributions and trends 1980–2001. Environ. Sci. Technol. 38, 1941–1948 (2004).

    Article  PubMed  CAS  Google Scholar 

  14. Wammer, K. H., Peters, C. A Polycyclic aromatic hydrocarbon biodegradation rates: A structure based study. Environ. Sci. Technol. 39, 2571–2578 (2005).

    Article  PubMed  CAS  Google Scholar 

  15. Sericano, J. L., Brooks, J. M., Champ, M. A., Kennicutt, M. C. & Makeyev, V. V. Trace contaminant concentrations in the Kara Sea and its adjacent rivers, Russia. Mar. Pollut. Bull. 42, 1017–1030 (2001).

    Article  PubMed  CAS  Google Scholar 

  16. Malik, A., Verma, P., Singh, A. K. & Singh, K. P. Distribution of polycyclic aromatic hydrocarbons in water and bed sediments of the Gomti River, India. Environ. Monit. Assess. 172, 529–545 (2011).

    Article  PubMed  CAS  Google Scholar 

  17. Gschwend, P. M. & Hites, R. A. Fluxes of polycyclic aromatic hydrocarbons to marine and lacustrine sediments in northeastern United States. Geochem. Cosmochim. Acta 45, 2359–2367 (1981).

    Article  CAS  Google Scholar 

  18. Colombo, J. C., Pelleitier, E., Brochu, C., Khalil, M. & Catoggio, A. (1989). Determination of hydrocarbon sources using n-alkanes and polycyclic aromatic hydrocarbon indexes, case study; Rio de la Plata, Argentina. Environ. Sci. Technol. 23, 888–894.

    Article  CAS  Google Scholar 

  19. Wilcke, W. et al. Polycyclic aromatic hydrocarbons (PAHs) patterns in climatically different ecological zones of Brazil. Org. Geochem. 34, 1405–1417 (2003).

    Article  CAS  Google Scholar 

  20. Ngange, T. N. et al. Polycyclic aromatic hydrocarbons in surface water and soil in the vicinity of fuel-oil spillage from a tank farm distribution facility, Esuk Utan, Calabar Municipality, Nigeria. Environ. Earth Sci. DOI 10.1007/s12665-011-1481-2 (2011).

  21. Olawoyin, R., Oyewole, S. A. & Grayson, R. L. Potential risk effect from elevated levels of soil heavy metals on human health in the Niger delta, Ecotoxicol. Environ. Saf. Available online 24 August 2012, ISSN0147-6513,10.1016/j.ecoenv.2012.08.004.

  22. Teal, J. M. et al. The West Falmouth oil spill after 20 years: Fate of fuel oil compounds and effects on animals. Mar. Pollut. Bull. 24, 607–614 (1992).

    Article  CAS  Google Scholar 

  23. U.S. EPA. Dermal exposure assessment: principles and applications. US Environmental Protection Administration. Washington DC: United States Environmental Protection Agency (1992).

    Google Scholar 

  24. Armstrong, B., Hutchinson, E., Fletcher, T. & Unwin, J. Lung cancer risk after exposure to polycyclic aromatic hydrocarbons: A review and meta-analysis. Environmental Health Perspectives 112, 970–978 (2004).

    Article  PubMed  CAS  Google Scholar 

  25. Yang, H. H., Lai, S. O., Hsieh, L. T., Hsueh, H. J. & Chi, T. W. Profiles of PAH emission from steel and iron industries. Chemosphere 48, 1061–1074 (2002).

    Article  PubMed  CAS  Google Scholar 

  26. Knox, E. G. & Gilman, E. A. Hazard proximities of childhood cancers in Great Britain from 1953–80. J. Epidemiol. Commun. H. 51, 151–159 (1997).

    Article  CAS  Google Scholar 

  27. Paigen, B. H. Effect of 3-methylcholanthrene on the development of aortic lesions in mice. Cancer Res. 45, 3850–3855 (1985).

    PubMed  CAS  Google Scholar 

  28. Hardin, J. A., Hinoshite, F. & Sherr, D. H. Mechanisms by which benzo[a]pyrene, an environmental carcinogen, suppresses B cell lymphopoesis. Toxicol. Appl. Pharmacol. 117, 155–164 (1992).

    Article  PubMed  CAS  Google Scholar 

  29. MacKenzie, K. M. & Angevine, D. M. Infertility in mice exposed in utero to benzo(a)pyrene. Biol. Reprod. 24, 183–191 (1981).

    Article  PubMed  CAS  Google Scholar 

  30. Armstrong, E. C. & Bonser, G. M. Squamous carcinoma of the forestomach and other lesions in mice following oral administration of 3:4:5:6-dibenzcarbazole. Br. J. Cancer 4, 203–211 (1950).

    Article  PubMed  CAS  Google Scholar 

  31. Legraverend, C., Harrison, D. E., Ruscetti, F. W. & Nebert, D. W. Bone marrow toxicity induced by oral benzo[a]pyrene: Protection resides at the level of the intestine and liver. Toxicol. Appl. Pharmacol. 70, 390–401 (1983).

    Article  PubMed  CAS  Google Scholar 

  32. Karakaya, A., Ates, I. & Yucesoy, B. (2004). Effects of occupational polycyclic aromatic hydrocarbon exposure on T-lymphocyte functions and natural killer cell activity in asphalt and coke oven workers. Hum. Exp. Toxicol. 23, 317–322.

    Article  PubMed  CAS  Google Scholar 

  33. Congressional Research Service (CRS). Nigeria: Elections and issues for Congress Updated. www.crs.gov: RL33964. Nigeria: Current Issues (2008).

    Google Scholar 

  34. Powell, C. B., Ibiebele, D. O., Bara, M., Dut Kwicz, B. & isoun, M. O. Oshika Oil Spill Environmental Impact; effect on Aquatic biology. pp. 168–178. Kaduna, Nigeria: NNPC/FMHE International Seminar on petroleum industry and the Nigerian Environment (1995).

    Google Scholar 

  35. Department of Petroleum Resources (DPR). Environmental guidelines and standards for the petroleum industry in Nigeria, Abuja, Nigeria: Department of Petroleum Resources (2002).

    Google Scholar 

  36. U.S. EPA. Method 3540C: Soxhlet extraction. Washington, DC: US Environmental Protection Agency (1996a).

    Google Scholar 

  37. U.S. EPA. Soil Screening Guidance: Technical Background Document. Washington, DC: Office of Emergency and Remedial Response. United States Environmental Protection Agency, OSWER No. 9355.4-17A, http:www.epa.gov/superfund/health/conmedia/soil/introtbd.htm (1996b).

    Google Scholar 

  38. U.S. EPA. Method 8270C: Semivolatile organic compounds by gas chromatography/mass spectrometry (GC/MS). Washington, DC: US Environmental Protection Agency (1996c).

    Google Scholar 

  39. Committee on the Institutional Means (CIM). An Assessment of the Risks to Public Health. Risk assessment in the federal government: managing the process. Washington, DC: National Academy Press (1983).

    Google Scholar 

  40. Thompson, T. S., Clement, R. E., Thornton, N. & Luyt, J. Formation and emission of PCDDs/PCDFs in the petroleum refining industry. Chemosphere 20, 1525–1532 (1990).

    Article  CAS  Google Scholar 

  41. Nisbet, I. C. T. & LaGoy, P. K. Toxic equivalency factors (TEFs) for polycyclic aromatic hydrocarbons (PAHs). Regul. Toxicol. Pharmacol. 16, 290–300 (1992).

    Article  PubMed  CAS  Google Scholar 

  42. U.S. EPA. Risk-Based Concentration Table. U.S. Environmental Protection Agency, Region III (1993 Third Quarter).

  43. Malcom, H. M. & Dobson, S. The calculation of an environmental assessment level (EAL) for atmospheric PAHs using relative potencies. London, UK: Department of the Environment; 1994. p. 34–46 (1994).

    Google Scholar 

  44. Larsen, J. C. & Larsen, P. B. Chemical carcinogens. In: Hester EE and Harrison RR. Air Pollution and Health. Cambridge, UK: The Royal Society of Chemistry, pp. 33–56 (1998).

    Chapter  Google Scholar 

  45. Collins, J. F., Brown, J. P., Dawson, S. V. & Marty, M. A. Risk assessment for benzo(a)pyrene. Regul. Toxicol. Pharmacol. 13, 170–184 (1991).

    Article  PubMed  CAS  Google Scholar 

  46. Wislocki, P. G. et al. Tumorigenicity of nitrated derivatives of pyrene, benz[a]anthracene,chrysene and benzo[a]pyrene in the newborn mouse assay. Carcinogenesis 7, 1317–1322 (1986).

    Article  PubMed  CAS  Google Scholar 

  47. Habs, M., Schmahl, D. & Misfeld, J. Local carcinogenicity of some environmentally relevant polycyclic aromatic hydrocarbons after lifelong topical application to mouse skin. Arch. Geschwulstforsch. 50, 266–274 (1980).

    PubMed  CAS  Google Scholar 

  48. Deutsch-Wenzel, R. P., Brune, H., Grimmer, O., Dettbarn, G. & Misfeld, J. Experimental studies in rat lungs on the carcinogenicity and dose-response relationships of eight frequently occurring environmental polycyclic aromatic hydrocarbons. J. Natl. Cancer Inst. 71, 539–544 (1983).

    PubMed  CAS  Google Scholar 

  49. Cavalieri, E. L., Rogan, E. G., Higginbotham, S., Cremonesi, P. & Salmasi, S. Tumor-initiating activity in mouse skin and carcinogenicity in rat mammary gland of dibenzo[a]pyrenes: The very potent environmental carcinogen dibenzo[a,l]pyrene. J. Cancer Res. Clin. Oncol. 115, 67–72 (1989).

    Article  PubMed  CAS  Google Scholar 

  50. Cavalieri, E. L. et al. Comparative dose-response tumorigenicity studies of dibenzo[alpha,l] pyrene versus 7,12-dimethylbenz[alpha]anthracene, benzo[alpha] pyrene and two dibenzo[alpha,l]pyrene dihydrodiols in mouse skin and rat mammary gland. Carcinogenesis 12, 1939–1944 (1991).

    Article  PubMed  CAS  Google Scholar 

  51. Wynder, E. L., Jr. & Hoffman, D. A study of tobacco carcinogenesis. VII. The role of higher polycyclic hydrocarbons. Cancer 12, 1079–1086 (1959).

    Article  PubMed  CAS  Google Scholar 

  52. Durant, J. L. Human cell mutagenicity of oxygenated, nitrated, and unsubstituted polycyclic aromatic hydrocarbons associated with urban aerosols. Mutat Res. 371, 123–157 (1996).

    Article  PubMed  CAS  Google Scholar 

  53. Durant, J. L. et al. Mutagenicity of C24H 14 PAH in human cells expressing cyp1A1. Mutat Res. 446, 1–14 (1999).

    Article  PubMed  CAS  Google Scholar 

  54. Petry, T., Schmid, P. & Schlatter, C. The use of toxic equivalency factors in assessing occupational and environmental health risk associated with exposure to airborne mixtures of polycyclic aromatic hydrocarbons PAHs. Chemosphere 32, 639–648 (1996).

    Article  PubMed  CAS  Google Scholar 

  55. U.S. EPA. Screening For Environmental Hazards at Sites With Contaminated Soil and Groundwater, Hazard Evaluation and Emergency Response. Retrieved March 12, 2012, from United States Environmental Protection Agency: http://hawaii.gov/health/environmental/hazard/index.html (2011).

  56. Peng, C. et al. Polycyclic aromatic hydrocarbons in urban soils of Beijing: status, sources, distribution and potential risk. Environ. Pollut. 159, 802–808 (2011).

    Article  PubMed  CAS  Google Scholar 

  57. Shi, G. T. et al. A comparative study of health risk of potentially toxic metals in urban and suburban road dust in the most populated city of China. Atmos. Environ. 45, 764–771 (2011).

    Article  CAS  Google Scholar 

  58. U.S. EPA. Risk assessment Guidance for superfund. volume I: human health evaluation manual (Part E, Supplemetal Guidance for dermal risk assessment), EPA/540/R/99/005. 7. Washington DC, USA: Office of Emergency and Remedial Response, United States Environmental Protection Agency (2001).

    Google Scholar 

  59. Ferreira-Baptista, L. & De Miguel, E. Geochemistry and risk assessment of street dust in Luanda, Angola: a tropical urban environment. Atmos. Environ. 39, 4501–4512 (2005).

    Article  CAS  Google Scholar 

  60. U.S. EPA. Risk Assessment Guidance for Superfund. Volume I, Human Health Evaluation Manual (Part A). Publication EPA/540/1-89/092. U.S. Environmental Protection Agency. Office of Emergency and Remedial Respons (1989a).

  61. U.S. EPA. Recommendation of the Technical Workgroup for Lead for an Interim Approach to Assessing Risks Associated with Adult Exposures to Lead in Soil. Technical Review Workgroup for Lead. Washington, D.C.: United States Environmental Protection Agency (1996).

    Google Scholar 

  62. SFT. Guidelines on risk assessment of contaminated sites. Norwegian Pollution Control Authority, SFT report 99.06 (1999).

  63. U.S. EPA. Risk Assessment Guidance for Superfund Volume I: Human Health Evaluation Manual (Part F, Supplemental Guidance for Inhalation Risk Assessment) Final. United States Environmental Protection Agency, OSWER 9285.7-82. http://www.epa.gov/oswer/riskassessment/ragsf/index.htm (2009).

  64. Chen, S. C. & Liao, C. M. Health risk assessment on human exposed to environmental polycyclic aromatic hydrocarbons pollution sources. Sci. Total Environ. 366, 112–123 (2006).

    Article  PubMed  CAS  Google Scholar 

  65. Wang, W. et al. Polycyclic aromatic hydrocarbons (PAHs) in urban surface dust of Guangzhou, China: Status, sources and human health risk assessment. Sci. Total Environ. 409, 4519–4527 (2011).

    Article  PubMed  CAS  Google Scholar 

  66. Tsai, P. J., Shieh, H. Y., Lee, W. J. & Lai, S. O. Health risk assessment for workers exposed to polycyclic aromatic hydrocarbons (PAHs) in carbon black manufacturing industry. Sci. Total Environ. 278, 137–150 (2001).

    Article  PubMed  CAS  Google Scholar 

  67. U.S. EPA. Risk Assessment Guidance for Superfund. Volume II, Human Health Evaluation Manual (Part A). U.S. Environmental Protection Agency. Office of Emergency and Remedial Response Publication EPA/540/1-89/001 (1989b).

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Authors and Affiliations

  1. Department of Energy and Mineral Engineering, Pennsylvania State University, University Park, Pennsylvania, 16802, USA

    Richard Olawoyin & R. Larry Grayson

  2. Division of Environmental Health Sciences, Faculty of Public Health, College of Medicine, University of Ibadan, Ibadan, Nigeria

    Oladapo T. Okareh

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  1. Richard Olawoyin
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Olawoyin, R., Larry Grayson, R. & Okareh, O.T. Eco-toxicological and epidemiological assessment of human exposure to polycyclic aromatic hydrocarbons in the Niger Delta, Nigeria. Toxicol. Environ. Health Sci. 4, 173–185 (2012). https://doi.org/10.1007/s13530-012-0133-6

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