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Immunohistochemical expression of prostate tumour overexpressed 1 (PTOV1) in atypical adenomatous hyperplasia (AAH) of the prostate

Additional evidence linking AAH to adenocarcinoma

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Abstract

Background

Prostate tumour overexpressed 1, PTOV1, was recently identified as a novel gene and protein during a differential display screening for genes overexpressed in prostate cancer (PCa). It has been suggested that overexpression of PTOV1 can contribute to the proliferative status of prostate tumour cells and thus to their biological behaviour.

Methods

PTOV1 and Ki67 were immunohistochemically evaluated in PCa, atypical adenomatous hyperplasia (AAH), high-grade prostatic intraepithelial neoplasia (HGPIN), and normal-looking epithelium (NEp) of the transition zone (TZ) in 40 radical prostatectomies with pT2a Gleason score 6 PCa (20 with AAH and 20 with HGPIN) and in 10 simple prostatectomies (SPs) (5 with AAH and 5 with HGPIN). The aim was to evaluate PTOV1 protein expression as a marker for tumor development and progression from AAH to PCa.

Results

The proportions of PTOV1 and Ki67 positive cells increased from NEp through AAH and HGPIN to PCa. In particular, the mean Hscore of PTOV1 expression in AAH was 110.90, i.e., close to three times that of NEp (40.76), similar to that of HGPIN (105.61) and lower than that of PCa (137.03). The mean values in AAH and HGPIN associated with cancer in the RPs were slightly higher than in the SPs.

Conclusion

Our findings related to PTOV1 expression in AAH, similar to those in HGPIN, provide additional evidence linking AAH to prostatic adenocarcinoma.

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Acknowledgements

This report was supported by grants from the Polytechnic University of the Marche Region (Ancona), Italy (MS and RM). The content of this paper is solely the responsibility of the authors and does not necessarily represent the official views of the Polytechnic University of the Marche Region (Ancona, Italy).

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Authors and Affiliations

  1. Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Via Conca 71, Torrette, 60126, Ancona, Italy

    Roberta Mazzucchelli, Marina Scarpelli, Francesca Barbisan, Alfredo Santinelli & Rodolfo Montironi

  2. Unit of Anatomic Pathology, Department of Surgery, Cordoba University Medical School, Cordoba, Spain

    Antonio Lopez-Beltran

  3. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA

    Liang Cheng

Authors
  1. Roberta Mazzucchelli
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  2. Marina Scarpelli
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  3. Francesca Barbisan
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  4. Alfredo Santinelli
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  5. Antonio Lopez-Beltran
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  6. Liang Cheng
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  7. Rodolfo Montironi
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Corresponding author

Correspondence to Rodolfo Montironi.

Additional information

Roberta Mazzucchelli and Marina Scarpelli contributed equally to this paper.

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Mazzucchelli, R., Scarpelli, M., Barbisan, F. et al. Immunohistochemical expression of prostate tumour overexpressed 1 (PTOV1) in atypical adenomatous hyperplasia (AAH) of the prostate. Cell Oncol. 36, 37–42 (2013). https://doi.org/10.1007/s13402-012-0111-7

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  • DOI: https://doi.org/10.1007/s13402-012-0111-7

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