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Interaction of declined handgrip strength and HIV infection on neurocognitive impairment

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A Correction to this article was published on 18 March 2022

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Abstract

Neurocognitive impairment (NCI) persists among people living with HIV (PLWH) despite the success of combination antiretroviral therapy (cART). Although muscular waning or decreased handgrip strength has been widely reported to be associated with cognitive erosion in general elders, such association has not been examined in PLWH who commonly experience decreased handgrip strength and NCI. Furthermore, whether HIV infection modifies such association remains to be addressed. A cross-sectional analysis was conducted with 2808 HIV-positive and 5402 HIV-negative adults participating in the baseline survey of the CHART (Comparative HIV and Aging Research in Taizhou) cohort, China, 2017 − 2019. HIV-positive individuals showed weaker handgrip strength than HIV-negative controls (34.0 kg vs 37.7 kg). Multivariate logistic regression analysis indicated that both HIV infection (aOR = 4.35, p < 0.001) and every 5-kg decrease in "Handgrip strength" (aOR = 1.27, p < 0.001) were significantly associated with NCI, and there was a significant interaction between reduced handgrip strength and HIV infection on NCI (aOR = 1.14, p = 0.015). In stratified analyses adjusting for potential confounders, the association between reduced handgrip strength and NCI was significant among PLWH at all age groups but only significant among HIV-negative controls at 30 − 44 and 60 − 89 ages. Handgrip strength decline is significantly associated with the risk of NCI among PLWH. HIV infection may exacerbate the adverse effect of poor handgrip strength on NCI, especially at younger ages. Early detection of handgrip strength decline could facilitate delivery of compensatory strategies or assistive services to PLWH with or at high risk of NCI.

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Funding

This study was supported by the China National Science and Technology Major Projects on Infectious Diseases (2018ZX10721102 − 004), the National Natural Science Foundation of China (81773485), and partially supported by Shanghai Municipal Health Commission (GWV-10.1-XK16). National Major Science and Technology Projects of China,2018ZX10721102-004,Na He,National Natural Science Foundation of China,81773485,Na He,Shanghai Municipal Health Bureau,GWTD2015S05,Na He

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Authors and Affiliations

  1. Department of Epidemiology, School of Public Health, The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, 200032, China

    Shiying Yuan, Haijiang Lin, Ruizi Shi, Jing Li, Lulu Xu, Shijie Qiao & Na He

  2. Taizhou City Center for Disease Control and Prevention, Taizhou City of Zhejiang Province, Taizhou, China

    Xiaoxiao Chen, Haijiang Lin & Yingying Ding

  3. Key Laboratory of Health Technology Assessment of National Commission of Health, Fudan University, Shanghai, China

    Na He

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  1. Shiying Yuan
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  2. Xiaoxiao Chen
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  3. Haijiang Lin
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  4. Ruizi Shi
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  9. Na He
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Contributions

SY and XC proposed and developed the research question. NH generally supervised the study. SY, XC, HL, RS, JL, LX, and SQ contributed to data collection and data management. SY and YD performed data analysis. SY drafted the manuscript. NH critically reviewed and edited the manuscript. All authors read and approved the final manuscript.

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Correspondence to Na He.

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Shiying Yuan and Xiaoxiao Chen contributed equally to the work.

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Yuan, S., Chen, X., Lin, H. et al. Interaction of declined handgrip strength and HIV infection on neurocognitive impairment. J. Neurovirol. 28, 217–224 (2022). https://doi.org/10.1007/s13365-021-01036-1

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  • DOI: https://doi.org/10.1007/s13365-021-01036-1

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