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Decreased MEG beta oscillations in HIV-infected older adults during the resting state

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Abstract

The introduction of combination antiretroviral therapy significantly reduced the prevalence of the most severe form of HIV-associated neurocognitive disorders (HAND). Despite this decline, 35–70 % of HIV-infected patients continue to develop mild motor and cognitive impairments. Although neuropsychological studies have shown that HAND affects a wide array of cognitive functions, a formal diagnosis is still based on the exclusion of opportunistic infections and other common ailments, as no specific tests or biomarkers are currently available. In this study, we used magnetoencephalography (MEG) to measure neural activity during the resting-state in 15 HIV-infected older patients and a demographically matched group of 15 uninfected controls. MEG is a noninvasive and direct measure of neural activity with excellent spatiotemporal resolution. All MEG data were coregistered to structural magnetic resonance images, corrected for head motion, fitted to a regional-level source model, and subjected to spectral analyses to quantify population-level neural oscillatory activity. We found that HIV-infected persons exhibited decreased beta oscillations in the supplementary motor area bilaterally, paracentral lobule, posterior cingulate, and bilateral regions of the superior parietal lobule relative to healthy controls. Beta oscillations in the posterior cingulate, a critical component of the default mode network, were also positively correlated with patient scores on the memory recall aspect of the Hopkins Verbal Learning Test-Revised. These results demonstrate that chronic HIV infection does not uniformly disturb cortical function, and that neuronal populations in dorsomedial motor and parietal cortices are especially affected. These findings also suggest that resting-state MEG recordings may hold significant promise as a functional biomarker for identifying HAND and monitoring disease progression.

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Acknowledgments

This work was supported by NIH grant P30 MH062261 (HSF). The Center for Magnetoencephalography at the University of Nebraska Medical Center was founded through an endowment from an anonymous donor. We would like to thank our participants for volunteering. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Conflicts of interest

KMB, EHG, HSF, JO’N, and TWW have no biomedical financial interests or potential conflicts of interest to report. KRR has served as a consultant for Abbott and GlaxoSmithKline. USS has served as a consultant for Merck and has received research grant support from Pfizer, Behring, and GlaxoSmithKline for research unrelated to this study. SS reports receiving grant support to the University of Nebraska Medical Center from GlaxoSmithKline and Pfizer for research unrelated to this study.

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Authors and Affiliations

  1. Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA

    Katherine M. Becker, Howard S. Fox & Tony W. Wilson

  2. Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA

    Uriel Sandkovsky, Jennifer O’Neill & Susan Swindells

  3. Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, USA

    Tony W. Wilson

  4. Center for Magnetoencephalography, University of Nebraska Medical Center, Omaha, NE, USA

    Katherine M. Becker, Elizabeth Heinrichs-Graham & Tony W. Wilson

  5. Department of Psychology, University of Nebraska-Omaha, Omaha, NE, USA

    Elizabeth Heinrichs-Graham

  6. Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC, USA

    Kevin R. Robertson

  7. Center for Magnetoencephalography, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, 988422 Nebraska Medical Center, Omaha, NE, 68198, USA

    Tony W. Wilson

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  1. Katherine M. Becker
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  2. Elizabeth Heinrichs-Graham
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  7. Susan Swindells
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  8. Tony W. Wilson
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Correspondence to Tony W. Wilson.

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Becker, K.M., Heinrichs-Graham, E., Fox, H.S. et al. Decreased MEG beta oscillations in HIV-infected older adults during the resting state. J. Neurovirol. 19, 586–594 (2013). https://doi.org/10.1007/s13365-013-0220-8

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  • DOI: https://doi.org/10.1007/s13365-013-0220-8

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