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Overtone Mobility Spectrometry: Part 5. Simulations and Analytical Expressions Describing Overtone Limits

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Journal of The American Society for Mass Spectrometry

Abstract

Mathematical expressions for the analytical duty cycle associated with different overtones in overtone mobility spectrometry are derived from the widths of the transmitted packets of ions under different instrumental operating conditions. Support for these derivations is provided through ion trajectory simulations. The outcome of the theory and simulations indicates that under all operating conditions there exists a limit or maximum observable overtone that will result in ion transmission. Implications of these findings on experimental design are discussed.

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Acknowledgments

The authors acknowledge partial support of this work provided by grants from the Analytical Node of the METACyt initiative funded by a grant from the Lilly Endowment and by the NIH (1RC1GM090798-01).

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  1. Stephen J. Valentine

    Present address: Department of Chemistry, West Virginia University, Morgantown, WV, 26506, USA

Authors and Affiliations

  1. Department of Chemistry, Indiana University, Bloomington, IN, 47405, USA

    Michael A. Ewing, Steven M. Zucker, Stephen J. Valentine & David E. Clemmer

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  1. Michael A. Ewing
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Correspondence to David E. Clemmer.

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Ewing, M.A., Zucker, S.M., Valentine, S.J. et al. Overtone Mobility Spectrometry: Part 5. Simulations and Analytical Expressions Describing Overtone Limits. J. Am. Soc. Mass Spectrom. 24, 615–621 (2013). https://doi.org/10.1007/s13361-012-0559-8

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  • DOI: https://doi.org/10.1007/s13361-012-0559-8

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